Iron deficiency anemia medical therapy: Difference between revisions

Jump to navigation Jump to search
m (Bot: Removing from Primary care)
 
(6 intermediate revisions by 2 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Iron deficiency anemia}}
{{Iron deficiency anemia}}
{{CMG}}; {{AE}}
{{CMG}}; {{AE}} {{JSS}}


{{PleaseHelp}}
{{PleaseHelp}}


==Overview==
==Overview==
Treatment of iron deficiency anemia includes iron supplementation and treating the cause of the iron deficiency. Treatment is given according to the severity of anemia.


==Medical Therapy==
==Medical Therapy==
* Iron supplementation is recommended among patients with iron deficiency anemia<ref name="pmid27913463">{{cite journal| author=Auerbach M, Deloughery T| title=Single-dose intravenous iron for iron deficiency: a new paradigm. | journal=Hematology Am Soc Hematol Educ Program | year= 2016 | volume= 2016 | issue= 1 | pages= 57-66 | pmid=27913463 | doi=10.1182/asheducation-2016.1.57 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27913463  }} </ref><ref name="pmid21705493">{{cite journal| author=Krayenbuehl PA, Battegay E, Breymann C, Furrer J, Schulthess G| title=Intravenous iron for the treatment of fatigue in nonanemic, premenopausal women with low serum ferritin concentration. | journal=Blood | year= 2011 | volume= 118 | issue= 12 | pages= 3222-7 | pmid=21705493 | doi=10.1182/blood-2011-04-346304 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21705493  }} </ref><ref name="pmid11506061">{{cite journal| author=Patterson AJ, Brown WJ, Roberts DC| title=Dietary and supplement treatment of iron deficiency results in improvements in general health and fatigue in Australian women of childbearing age. | journal=J Am Coll Nutr | year= 2001 | volume= 20 | issue= 4 | pages= 337-42 | pmid=11506061 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11506061  }} </ref><ref name="pmid12763985">{{cite journal| author=Verdon F, Burnand B, Stubi CL, Bonard C, Graff M, Michaud A et al.| title=Iron supplementation for unexplained fatigue in non-anaemic women: double blind randomised placebo controlled trial. | journal=BMJ | year= 2003 | volume= 326 | issue= 7399 | pages= 1124 | pmid=12763985 | doi=10.1136/bmj.326.7399.1124 | pmc=156009 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12763985  }}  [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=&cmd=prlinks&id=15122863 Review in: ACP J Club. 2004 Mar-Apr;140(2):43] </ref><ref name="pmid28034892">{{cite journal| author=Achebe MM, Gafter-Gvili A| title=How I treat anemia in pregnancy: iron, cobalamin, and folate. | journal=Blood | year= 2017 | volume= 129 | issue= 8 | pages= 940-949 | pmid=28034892 | doi=10.1182/blood-2016-08-672246 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28034892  }} </ref>.
* Pharmacologic medical therapies for iron deficiency anemia include (either) oral iron supplements, parenteral iron supplements, erythropoetin and blood transfusion.
=== Iron deficiency anemia ===
* '''1. Mild anemia'''
** '''1.1 Adults- (Hb -11.0-11.9 g/dL in women and 11.0-12.9 g/dL in men''')
*** Ferrous sulfate/ferrous gluconate/ferrous fumarate PO 100mg per day for 4 weeks.
** 1.2 Pediatrics- (Hb <9g/dl)
*** Ferrous sulfate 3mg/kg PO for 8-12 weeks.
* 2. Moderate anemia
** 2.1- Adults( Hb 7-11g/dL)
*** Ferric carboxymaltose in a dose of 750mg ( 50mg/ml/min) IV once a week for 2-4 weeks.
** 2.2 Paediatrics- (Hb 5-9g/dl)
*** Iron sucrose in a dose of 200mg (30mg/ml/min) IV once a week for 2-4 weeks.
* 3. Severe anemia
** 3.1 Adults (Hb <7g/dl in individuals without co morbidities and <8g/dl in patients with heart diseases)
*** Blood transfusion- units of packed red blood cellsdepending on the Hb level
*** 2 units of blood increase 1 g/dl of Hb.
** 3.2 Paediatrics (Hb <5g/dl)
*** Blood transfusion- Units of packed red blood cells depending on the Hb level.
*** 1 unit given over 3-4 hours.
* Intravenous formulations of iron include ferric carboxymaltose, iron dextran, and iron sucrose.
* Iron deficient individuals need to consume iron rich diet.
* Source of iron rich foods is mentioned below:
{{Col-begin}}
{{Col-begin}}
{{Col-2}}
{{Col-2}}
Line 176: Line 205:
==References==
==References==
{{reflist|2}}
{{reflist|2}}
{{WH}}
{{WS}}


[[Category:Hematology]]
[[Category:Hematology]]
[[Category:Gastroenterology]]
[[Category:Gastroenterology]]
[[Category:Primary care]]
[[Category:Endocrinology]]
[[Category:Endocrinology]]
{{WH}}
{{WS}}

Latest revision as of 22:25, 29 July 2020

Iron deficiency anemia Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Iron deficiency anemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Iron deficiency anemia medical therapy On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Iron deficiency anemia medical therapy

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Iron deficiency anemia medical therapy

CDC on Iron deficiency anemia medical therapy

Iron deficiency anemia medical therapy in the news

Blogs on Iron deficiency anemia medical therapy

Directions to Hospitals Treating Iron deficiency anemia

Risk calculators and risk factors for Iron deficiency anemia medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Jogeet Singh Sekhon, M.D. [2]

Please help WikiDoc by adding content here. It's easy! Click here to learn about editing.

Overview

Treatment of iron deficiency anemia includes iron supplementation and treating the cause of the iron deficiency. Treatment is given according to the severity of anemia.

Medical Therapy

  • Iron supplementation is recommended among patients with iron deficiency anemia[1][2][3][4][5].
  • Pharmacologic medical therapies for iron deficiency anemia include (either) oral iron supplements, parenteral iron supplements, erythropoetin and blood transfusion.

Iron deficiency anemia

  • 1. Mild anemia
    • 1.1 Adults- (Hb -11.0-11.9 g/dL in women and 11.0-12.9 g/dL in men)
      • Ferrous sulfate/ferrous gluconate/ferrous fumarate PO 100mg per day for 4 weeks.
    • 1.2 Pediatrics- (Hb <9g/dl)
      • Ferrous sulfate 3mg/kg PO for 8-12 weeks.
  • 2. Moderate anemia
    • 2.1- Adults( Hb 7-11g/dL)
      • Ferric carboxymaltose in a dose of 750mg ( 50mg/ml/min) IV once a week for 2-4 weeks.
    • 2.2 Paediatrics- (Hb 5-9g/dl)
      • Iron sucrose in a dose of 200mg (30mg/ml/min) IV once a week for 2-4 weeks.
  • 3. Severe anemia
    • 3.1 Adults (Hb <7g/dl in individuals without co morbidities and <8g/dl in patients with heart diseases)
      • Blood transfusion- units of packed red blood cellsdepending on the Hb level
      • 2 units of blood increase 1 g/dl of Hb.
    • 3.2 Paediatrics (Hb <5g/dl)
      • Blood transfusion- Units of packed red blood cells depending on the Hb level.
      • 1 unit given over 3-4 hours.
  • Intravenous formulations of iron include ferric carboxymaltose, iron dextran, and iron sucrose.
  • Iron deficient individuals need to consume iron rich diet.
  • Source of iron rich foods is mentioned below:
Template:Col-2
Selected Food Sources of Heme Iron
Food Serving
size
Miligrams
per serving
% DV*
Chicken liver (cooked) 3˝ ounces 12.8 70
Oysters(breaded and fried) 6 pieces 4.5 25
Beef, chuck (lean, braised) 3 ounces 3.2 20
Clams (breaded, fried) 1 cup 3.0 15
Beef tenderloin (roasted) 3 ounces 3.0 15
Turkey ( dark meat, roasted) 3˝ ounces 2.3 10
Beef, eye of round (roasted) 3 ounces 2.2 10
Turkey, light meat (roasted) 3˝ ounces 1.6 8
Chicken, leg, meat only (roasted) 3˝ ounces 1.3 6
Tuna, fresh bluefin (cooked) 3 ounces 1.1 6
Chicken breast (roasted) 3 ounces 1.1 6
Halibut (cooked) 3 ounces 0.9 6
Blue crab (cooked) 3 ounces 0.8 4
Pork loin (broiled) 3 ounces 0.8 4
Tuna white (canned in water) 3 ounces 0.8 4
Shrimp (mixed species, cooked) 4 large 0.7 4

Template:Col-2

Selected Food Sources of Nonheme Iron
Food Serving
size
Miligrams
per serving
% DV*
Ready-to-eat cereal (100% iron fortified cup 18.0 100
Oatmeal, instant, fortified (prepared with water 1 cup 10.0 60
Soybeans, mature (boiled) 1 cup 8.8 50
Lentils (boiled) 1 cup 6.6 35
Kidney beans mature (boiled) 1 cup 5.2 25
Lima beans large, mature (boiled) 1 cup 4.5 25
Navy beans mature (boiled) 1 cup 4.5 25
Ready-to-eat cereal (25% iron fortified) 1 cup 4.5 25
Black beans mature (boiled) 1 cup 3.6 20
Pinto beans mature (boiled) 1 cup 3.6 20
Molasses (blackstrap) 1 tablespoon 3.5 20
Tofu (raw, firm) ˝ cup 3.4 20
Spinach (boiled, drained) ˝ cup 3.2 20
Spinach (canned, drained solids) ˝ cup 2.5 10
Black-eyed peas (cowpeas) (boiled) ˝ cup 1.8 10
Spinach (frozen, chopped, boiled) ˝ cup 1.9 10
Grits (white, enriched 1 cup 1.5 8
Raisins (seedless, packed) ˝ cup 1.5 8
Whole wheat bread 1 slice 0.9 6
White bread (enriched) 1 slice 0.9 6

References

  1. Auerbach M, Deloughery T (2016). "Single-dose intravenous iron for iron deficiency: a new paradigm". Hematology Am Soc Hematol Educ Program. 2016 (1): 57–66. doi:10.1182/asheducation-2016.1.57. PMID 27913463.
  2. Krayenbuehl PA, Battegay E, Breymann C, Furrer J, Schulthess G (2011). "Intravenous iron for the treatment of fatigue in nonanemic, premenopausal women with low serum ferritin concentration". Blood. 118 (12): 3222–7. doi:10.1182/blood-2011-04-346304. PMID 21705493.
  3. Patterson AJ, Brown WJ, Roberts DC (2001). "Dietary and supplement treatment of iron deficiency results in improvements in general health and fatigue in Australian women of childbearing age". J Am Coll Nutr. 20 (4): 337–42. PMID 11506061.
  4. Verdon F, Burnand B, Stubi CL, Bonard C, Graff M, Michaud A; et al. (2003). "Iron supplementation for unexplained fatigue in non-anaemic women: double blind randomised placebo controlled trial". BMJ. 326 (7399): 1124. doi:10.1136/bmj.326.7399.1124. PMC 156009. PMID 12763985. Review in: ACP J Club. 2004 Mar-Apr;140(2):43
  5. Achebe MM, Gafter-Gvili A (2017). "How I treat anemia in pregnancy: iron, cobalamin, and folate". Blood. 129 (8): 940–949. doi:10.1182/blood-2016-08-672246. PMID 28034892.

Template:WH Template:WS