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==Overview==
==Overview==
The classification of hepato-renal syndrome is based on the deteriorating function of kidney.
==Classification==
==Classification==
The hepatorenal syndrome is defined as renal failure that occurs in the setting of liver disease as follows:
The hepatorenal syndrome is defined as renal failure that occurs in the setting of liver disease as follows:
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* Increase in serum [[creatinine]] level to greater than 133 μmol/L (1.5 mg/dL) or a creatinine clearance of less than 40 mL/min
* Increase in serum [[creatinine]] level to greater than 133 μmol/L (1.5 mg/dL) or a creatinine clearance of less than 40 mL/min
* Urine sodium < 10 meq/dl<ref name="pmid3297907">{{cite journal |author=Ginés P, Arroyo V, Quintero E, ''et al'' |title=Comparison of paracentesis and diuretics in the treatment of cirrhotics with tense ascites. Results of a randomized study |journal=Gastroenterology |volume=93 |issue=2 |pages=234-41 |year=1987 |pmid=3297907 |doi=}}</ref>
* Urine sodium < 10 meq/dl<ref name="pmid3297907">{{cite journal |author=Ginés P, Arroyo V, Quintero E, ''et al'' |title=Comparison of paracentesis and diuretics in the treatment of cirrhotics with tense ascites. Results of a randomized study |journal=Gastroenterology |volume=93 |issue=2 |pages=234-41 |year=1987 |pmid=3297907 |doi=}}</ref>
==== Classification on basis of mechanism of kidney injury in presence of liver failure: ====
# '''Hypovoluemia induced kidney injury:''' It occurs due to loss of fluid through GIT or GI bleed in presence of liver failure which predisposed kidney to hypovolumic injury.
# '''Parencheymal renal disease:''' In presence protienurea above 500 mg/dl and hemeturia above 50 red cells points to kidney injury primarily otherwise it points to liver damage promoting kidney injury.
# '''Drug induced hepato-nephrotoxicity:''' When drugs like acetaminophen and anti microbial causing hepatotoxicty and nephrotoxicity are taken together they can also produce combed damage.


==References==
==References==

Revision as of 14:37, 5 December 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sunny Kumar MD [2]

Overview

The classification of hepato-renal syndrome is based on the deteriorating function of kidney.

Classification

The hepatorenal syndrome is defined as renal failure that occurs in the setting of liver disease as follows:

Type I HRS

Type I HRS is characterized by rapidly progressive renal failure with a doubling of serum creatinine to a level greater than 221 μmol/L (2.5 mg/dL) or a halving of the creatinine clearance to less than 20 mL/min over a period of less than 2 weeks.

Type II HRS

Type II HRS is characterized by a slowly progressive:

  • Increase in serum creatinine level to greater than 133 μmol/L (1.5 mg/dL) or a creatinine clearance of less than 40 mL/min
  • Urine sodium < 10 meq/dl[1]

Classification on basis of mechanism of kidney injury in presence of liver failure:

  1. Hypovoluemia induced kidney injury: It occurs due to loss of fluid through GIT or GI bleed in presence of liver failure which predisposed kidney to hypovolumic injury.
  2. Parencheymal renal disease: In presence protienurea above 500 mg/dl and hemeturia above 50 red cells points to kidney injury primarily otherwise it points to liver damage promoting kidney injury.
  3. Drug induced hepato-nephrotoxicity: When drugs like acetaminophen and anti microbial causing hepatotoxicty and nephrotoxicity are taken together they can also produce combed damage.

References

  1. Ginés P, Arroyo V, Quintero E; et al. (1987). "Comparison of paracentesis and diuretics in the treatment of cirrhotics with tense ascites. Results of a randomized study". Gastroenterology. 93 (2): 234–41. PMID 3297907.

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