Ganglioglioma pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Ganglioglioma arises from neuronal glial cells, which are cells of the central nervous system. On gross pathology, ganglioglioma varies from partially cystic mass with a mural nodule to a solid mass expanding the overlying gyrus. On microscopic pathology, ganglioglioma is composed of ganglion cells and neoplastic glial cells with positive staining for synaptophysin, neuronal specific enolase, and GFAP.

Pathophysiology

Gross Pathology

Microscopic Pathology

Gangliogliomas are composed of two cell populations:[1]

  • Ganglion cells (large mature neuronal elements): ganglio-
  • Neoplastic glial elements (astrocytic): -glioma

The glial component determines the biological behaviour of ganglioglioma. Dedifferentiation into high grade tumors may occur, and usually involves the glial component.

Markers

Neuronal origin is demonstrated by positivity to neuronal markers:[1]

References

  1. 1.0 1.1 1.2 Pathophysiology of ganglioglioma. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/ganglioglioma


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