FABP6: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Fatty acid binding protein 6, ileal (gastrotropin)''', also known as '''FABP6''', is a [[protein]] which in humans is encoded by the ''FABP6'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FABP6 fatty acid binding protein 6, ileal (gastrotropin)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2172| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_FABP6_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1o1u.
| PDB = {{PDB2|1o1u}}, {{PDB2|1o1v}}
| Name = Fatty acid binding protein 6, ileal (gastrotropin)
| HGNCid = 3561
| Symbol = FABP6
| AltSymbols =; I-15P; I-BABP; I-BALB; I-BAP; ILBP; ILBP3; ILLBP
| OMIM = 600422
| ECnumber = 
| Homologene = 1108
| MGIid = 96565
| GeneAtlas_image1 = PBB_GE_FABP6_210445_at_tn.png
| Function = {{GNF_GO|id=GO:0005504 |text = fatty acid binding}} {{GNF_GO|id=GO:0008289 |text = lipid binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2172
    | Hs_Ensembl = ENSG00000170231
    | Hs_RefseqProtein = NP_001035532
    | Hs_RefseqmRNA = NM_001040442
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 159573319
    | Hs_GenLoc_end = 159598307
    | Hs_Uniprot = P51161
    | Mm_EntrezGene = 16204
    | Mm_Ensembl = ENSMUSG00000020405
    | Mm_RefseqmRNA = NM_008375
    | Mm_RefseqProtein = NP_032401
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 43439535
    | Mm_GenLoc_end = 43444934
    | Mm_Uniprot = Q5SRT9
  }}
}}
'''Fatty acid binding protein 6, ileal (gastrotropin)''', also known as '''FABP6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: FABP6 fatty acid binding protein 6, ileal (gastrotropin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2172| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes the [[ileum|ileal]] [[fatty acid binding protein]]. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain [[fatty acid]]s and other hydrophobic ligands. FABP6 and [[FABP1]] (the liver fatty acid binding protein) are also able to bind [[bile acid]]s. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: FABP6 fatty acid binding protein 6, ileal (gastrotropin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2172| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Börchers T, Hohoff C, Buhlmann C, Spener F |title=Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation. |journal=Prostaglandins Leukot. Essent. Fatty Acids |volume=57 |issue= 1 |pages= 77-84 |year= 1997 |pmid= 9250612 |doi=  }}
*{{cite journal  | vauthors=Börchers T, Hohoff C, Buhlmann C, Spener F |title=Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation. |journal=Prostaglandins Leukot. Essent. Fatty Acids |volume=57 |issue= 1 |pages= 77–84 |year= 1997 |pmid= 9250612 |doi=10.1016/S0952-3278(97)90496-8 }}
*{{cite journal  | author=Fujita M, Fujii H, Kanda T, ''et al.'' |title=Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein. |journal=Eur. J. Biochem. |volume=233 |issue= 2 |pages= 406-13 |year= 1995 |pmid= 7588781 |doi=  }}
*{{cite journal  | vauthors=Fujita M, Fujii H, Kanda T |title=Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein. |journal=Eur. J. Biochem. |volume=233 |issue= 2 |pages= 406–13 |year= 1995 |pmid= 7588781 |doi=10.1111/j.1432-1033.1995.406_2.x |display-authors=etal}}
*{{cite journal  | author=Oelkers P, Dawson PA |title=Cloning and chromosomal localization of the human ileal lipid-binding protein. |journal=Biochim. Biophys. Acta |volume=1257 |issue= 2 |pages= 199-202 |year= 1995 |pmid= 7619861 |doi=  }}
*{{cite journal  | vauthors=Oelkers P, Dawson PA |title=Cloning and chromosomal localization of the human ileal lipid-binding protein. |journal=Biochim. Biophys. Acta |volume=1257 |issue= 2 |pages= 199–202 |year= 1995 |pmid= 7619861 |doi=  10.1016/0005-2760(95)00098-w}}
*{{cite journal  | author=Birkenmeier EH, Rowe LB, Crossman MW, Gordon JI |title=Ileal lipid-binding protein (Illbp) gene maps to mouse chromosome 11. |journal=Mamm. Genome |volume=5 |issue= 12 |pages= 805-6 |year= 1995 |pmid= 7894165 |doi=  }}
*{{cite journal  | vauthors=Birkenmeier EH, Rowe LB, Crossman MW, Gordon JI |title=Ileal lipid-binding protein (Illbp) gene maps to mouse chromosome 11. |journal=Mamm. Genome |volume=5 |issue= 12 |pages= 805–6 |year= 1995 |pmid= 7894165 |doi=10.1007/BF00292019 }}
*{{cite journal  | author=Watanabe K, Hoshi N, Tsuura Y, ''et al.'' |title=Immunohistochemical distribution of intestinal 15 kDa protein in human tissues. |journal=Arch. Histol. Cytol. |volume=58 |issue= 3 |pages= 303-6 |year= 1996 |pmid= 8527237 |doi=  }}
*{{cite journal  | vauthors=Watanabe K, Hoshi N, Tsuura Y |title=Immunohistochemical distribution of intestinal 15 kDa protein in human tissues. |journal=Arch. Histol. Cytol. |volume=58 |issue= 3 |pages= 303–6 |year= 1996 |pmid= 8527237 |doi=10.1679/aohc.58.303 |display-authors=etal}}
*{{cite journal  | author=Lücke C, Zhang F, Rüterjans H, ''et al.'' |title=Flexibility is a likely determinant of binding specificity in the case of ileal lipid binding protein. |journal=Structure |volume=4 |issue= 7 |pages= 785-800 |year= 1997 |pmid= 8805562 |doi=  }}
*{{cite journal  | vauthors=Lücke C, Zhang F, Rüterjans H |title=Flexibility is a likely determinant of binding specificity in the case of ileal lipid binding protein. |journal=Structure |volume=4 |issue= 7 |pages= 785–800 |year= 1997 |pmid= 8805562 |doi=10.1016/S0969-2126(96)00086-X |display-authors=etal}}
*{{cite journal  | author=Grober J, Zaghini I, Fujii H, ''et al.'' |title=Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 29749-54 |year= 1999 |pmid= 10514450 |doi= }}
*{{cite journal  | vauthors=Grober J, Zaghini I, Fujii H |title=Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 29749–54 |year= 1999 |pmid= 10514450 |doi=10.1074/jbc.274.42.29749  |display-authors=etal}}
*{{cite journal  | author=Seibert C, Harteneck C, Ernst OP, ''et al.'' |title=Activation of the rod G-protein Gt by the thrombin receptor (PAR1) expressed in Sf9 cells. |journal=Eur. J. Biochem. |volume=266 |issue= 3 |pages= 911-6 |year= 2000 |pmid= 10583385 |doi=  }}
*{{cite journal  | vauthors=Seibert C, Harteneck C, Ernst OP |title=Activation of the rod G-protein Gt by the thrombin receptor (PAR1) expressed in Sf9 cells. |journal=Eur. J. Biochem. |volume=266 |issue= 3 |pages= 911–6 |year= 2000 |pmid= 10583385 |doi=10.1046/j.1432-1327.1999.00927.x |display-authors=etal}}
*{{cite journal  | author=Lücke C, Zhang F, Hamilton JA, ''et al.'' |title=Solution structure of ileal lipid binding protein in complex with glycocholate. |journal=Eur. J. Biochem. |volume=267 |issue= 10 |pages= 2929-38 |year= 2000 |pmid= 10806391 |doi=  }}
*{{cite journal  | vauthors=Lücke C, Zhang F, Hamilton JA |title=Solution structure of ileal lipid binding protein in complex with glycocholate. |journal=Eur. J. Biochem. |volume=267 |issue= 10 |pages= 2929–38 |year= 2000 |pmid= 10806391 |doi=10.1046/j.1432-1327.2000.01307.x |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Kurz M, Brachvogel V, Matter H, ''et al.'' |title=Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. |journal=Proteins |volume=50 |issue= 2 |pages= 312-28 |year= 2003 |pmid= 12486725 |doi= 10.1002/prot.10289 }}
*{{cite journal  | vauthors=Kurz M, Brachvogel V, Matter H |title=Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures |journal=Proteins |volume=50 |issue= 2 |pages= 312–28 |year= 2003 |pmid= 12486725 |doi= 10.1002/prot.10289 |display-authors=etal}}
*{{cite journal  | author=Barley NF, Taylor V, Shaw-Smith CJ, ''et al.'' |title=Human ileal bile acid-binding protein promoter and the effects of CDX2. |journal=Biochim. Biophys. Acta |volume=1630 |issue= 2-3 |pages= 138-43 |year= 2004 |pmid= 14654244 |doi=  }}
*{{cite journal  | vauthors=Barley NF, Taylor V, Shaw-Smith CJ |title=Human ileal bile acid-binding protein promoter and the effects of CDX2 |journal=Biochim. Biophys. Acta |volume=1630 |issue= 2–3 |pages= 138–43 |year= 2004 |pmid= 14654244 |doi=  10.1016/j.bbaexp.2003.09.008|display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Landrier JF, Thomas C, Grober J, ''et al.'' |title=The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors. |journal=Biochim. Biophys. Acta |volume=1735 |issue= 1 |pages= 41-9 |year= 2005 |pmid= 15936983 |doi= 10.1016/j.bbalip.2005.05.002 }}
*{{cite journal  | vauthors=Landrier JF, Thomas C, Grober J |title=The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors |journal=Biochim. Biophys. Acta |volume=1735 |issue= 1 |pages= 41–9 |year= 2005 |pmid= 15936983 |doi= 10.1016/j.bbalip.2005.05.002 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Bergheim I, Harsch S, Mueller O, ''et al.'' |title=Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers. |journal=J. Lipid Res. |volume=47 |issue= 1 |pages= 42-50 |year= 2006 |pmid= 16237211 |doi= 10.1194/jlr.M500215-JLR200 }}
*{{cite journal  | vauthors=Bergheim I, Harsch S, Mueller O |title=Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers |journal=J. Lipid Res. |volume=47 |issue= 1 |pages= 42–50 |year= 2006 |pmid= 16237211 |doi= 10.1194/jlr.M500215-JLR200 |display-authors=etal}}
*{{cite journal  | author=Ohmachi T, Inoue H, Mimori K, ''et al.'' |title=Fatty acid binding protein 6 is overexpressed in colorectal cancer. |journal=Clin. Cancer Res. |volume=12 |issue= 17 |pages= 5090-5 |year= 2007 |pmid= 16951225 |doi= 10.1158/1078-0432.CCR-05-2045 }}
*{{cite journal  | vauthors=Ohmachi T, Inoue H, Mimori K |title=Fatty acid binding protein 6 is overexpressed in colorectal cancer |journal=Clin. Cancer Res. |volume=12 |issue= 17 |pages= 5090–5 |year= 2007 |pmid= 16951225 |doi= 10.1158/1078-0432.CCR-05-2045 |display-authors=etal}}
*{{cite journal  | author=Fang C, Dean J, Smith JW |title=A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappaB activation in colorectal adenocarcinoma. |journal=Cancer Res. |volume=67 |issue= 19 |pages= 9039-46 |year= 2007 |pmid= 17909007 |doi= 10.1158/0008-5472.CAN-06-3690 }}
*{{cite journal  | vauthors=Fang C, Dean J, Smith JW |title=A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappaB activation in colorectal adenocarcinoma |journal=Cancer Res. |volume=67 |issue= 19 |pages= 9039–46 |year= 2007 |pmid= 17909007 |doi= 10.1158/0008-5472.CAN-06-3690 }}
}}
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{{refend}}
{{refend}}
{{PDB Gallery|geneid=2172}}
{{Carrier proteins}}
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Latest revision as of 04:31, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Fatty acid binding protein 6, ileal (gastrotropin), also known as FABP6, is a protein which in humans is encoded by the FABP6 gene.[1]

Function

This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: FABP6 fatty acid binding protein 6, ileal (gastrotropin)".

Further reading



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