Endocarditis classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Maliha Shakil, M.D. [2]

Overview

Endocarditis may be classified based on the underlying pathophysiology of the process (infective vs. non-infective), the onset of the disease (acute vs. subacute or short incubation vs. long incubation), results of the cultures (culture positive vs. culture negative), the nature of the valve (native vs. prosthetic) and the valve affected (aortic, mitral, or tricuspid valve).

Classification

Infective Endocarditis vs. Non-Infective Endocarditis

Short Incubation vs. Long Incubation

Traditionally, infective endocarditis has been clinically divided into acute and subacute endocarditis.[1] This classifies both the rate of progression and severity of disease. Thus subacute bacterial endocarditis (SBE) is often due to streptococci of low virulence and mild to moderate illness which progresses slowly over weeks and months, while acute bacterial endocarditis (ABE) is a fulminant illness that progresses rapidly over days to weeks and is more likely to be due to Staphylococcus aureus, which has much greater virulence.[1] The terms short incubation (<6 weeks) and long incubation (>6 weeks) are preferred.[1]

Culture Positive vs. Culture Negative

Infective endocarditis may also be classified as culture-positive or culture-negative.[1] Culture-negative endocarditis is due to micro-organisms that require a longer period of time to be identified in the laboratory.[1] Such organisms are said to be fastidious because they have demanding growth requirements. Some pathogens responsible for culture-negative endocarditis include Aspergillus species, Brucella species, Coxiella burnetii, Chlamydia species, and HACEK bacteria.[1]

Native Valve Endocarditis vs. Prosthetic Valve Endocarditis

Finally, the distinction between native-valve endocarditis and prosthetic-valve endocarditis is clinically important. Prosthetic-valve endocarditis constitutes 10-20% of cases of endocarditis. The greatest risk is during the first 6 months after valve surgery. Staphylococcus epidermidis is the most common cause.

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Infective endocarditis. Wikipedia (2015). https://en.wikipedia.org/wiki/Infective_endocarditis#Pathogenesis Accessed on September 21, 2015
  2. Endocarditis. Wikipedia (2015). https://en.wikipedia.org/wiki/Endocarditis Accessed on September 21, 2015

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