Delayed puberty MRI: Difference between revisions
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==Overview== | ==Overview== | ||
[[Brain]] [[MRI]] may be helpful in the diagnosis of delayed [[puberty]]. Findings on [[MRI]] suggestive of delayed [[puberty]] include [[Hypothalamus|hypothalamo]]-[[pituitary]] lesions, [[Aplasia]] of [[olfactory bulb]] and/or [[Sulci (anatomy)|sulci]] ([[Kallmann syndrome]]), [[Optic nerve]] compression ([[pituitary adenoma]]), and [[Inner ear]] abnormalities ([[CHARGE syndrome]]). Showing the [[aplasia]] of [[olfactory bulbs]] and/or [[Sulci (anatomy)|sulci]] in [[MRI]], it is assumed as differentiation of [[Kallmann syndrome]] from isolated [[hypogonadotropic hypogonadism]], in patient without smelling problems or hard to evaluate. | |||
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| [[image:Webp.net-gifmaker (35).gif|thumb|500px|Absent right olfactory bulb - Case courtesy of Dr Joseph Scheller, <a href="https://radiopaedia.org/">Radiopaedia.org</a>. From the case <a href="https://radiopaedia.org/cases/54233">rID: 54233</a>]] | | [[image:Webp.net-gifmaker (35).gif|thumb|500px|Absent right olfactory bulb - Case courtesy of Dr Joseph Scheller, <a href="https://radiopaedia.org/">Radiopaedia.org</a>. From the case <a href="https://radiopaedia.org/cases/54233">rID: 54233</a>]] | ||
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* A moderate agreement is seen between the smell identification test (UPSIT) and presence of the [[olfactory bulbs]] in [[MRI]], in patients with [[hypogonadotropic hypogonadism]]. While, there is a good agreement between them in absence of the [[olfactory bulbs]] in [[MRI]] and [[anosmia]].<ref name="pmid6694486">{{cite journal |vauthors=Doty RL, Shaman P, Kimmelman CP, Dann MS |title=University of Pennsylvania Smell Identification Test: a rapid quantitative olfactory function test for the clinic |journal=Laryngoscope |volume=94 |issue=2 Pt 1 |pages=176–8 |year=1984 |pmid=6694486 |doi= |url=}}</ref><ref name="PalmertDunkel2012" /> | * A moderate agreement is seen between the smell identification test (UPSIT) and presence of the [[olfactory bulbs]] in [[MRI]], in patients with [[hypogonadotropic hypogonadism]]. While, there is a good agreement between them in absence of the [[olfactory bulbs]] in [[MRI]] and [[anosmia]].<ref name="pmid6694486">{{cite journal |vauthors=Doty RL, Shaman P, Kimmelman CP, Dann MS |title=University of Pennsylvania Smell Identification Test: a rapid quantitative olfactory function test for the clinic |journal=Laryngoscope |volume=94 |issue=2 Pt 1 |pages=176–8 |year=1984 |pmid=6694486 |doi= |url=}}</ref><ref name="PalmertDunkel2012" /> | ||
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image:Pituitary-adenoma-1.jpg|thumb|300px|Pituitary adenoma - Case courtesy of A.Prof Frank Gaillard, <a href="https://radiopaedia.org/">Radiopaedia.org</a>. From the case <a href="https://radiopaedia.org/cases/16890">rID: 16890</a> | image:Pituitary-adenoma-1.jpg|thumb|300px|Pituitary adenoma - Case courtesy of A.Prof Frank Gaillard, <a href="https://radiopaedia.org/">Radiopaedia.org</a>. From the case <a href="https://radiopaedia.org/cases/16890">rID: 16890</a> | ||
image:Hypothalamic-hamartoma.jpeg|thumb|300px|Hypothalamic lesion - Case courtesy of A.Prof Frank Gaillard, <a href="https://radiopaedia.org/">Radiopaedia.org</a>. From the case <a href="https://radiopaedia.org/cases/16890">rID: 16890</a> | image:Hypothalamic-hamartoma.jpeg|thumb|300px|Hypothalamic lesion - Case courtesy of A.Prof Frank Gaillard, <a href="https://radiopaedia.org/">Radiopaedia.org</a>. From the case <a href="https://radiopaedia.org/cases/16890">rID: 16890</a> | ||
Revision as of 17:20, 11 September 2017
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Delayed puberty Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Delayed puberty MRI On the Web |
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American Roentgen Ray Society Images of Delayed puberty MRI |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Brain MRI may be helpful in the diagnosis of delayed puberty. Findings on MRI suggestive of delayed puberty include hypothalamo-pituitary lesions, Aplasia of olfactory bulb and/or sulci (Kallmann syndrome), Optic nerve compression (pituitary adenoma), and Inner ear abnormalities (CHARGE syndrome). Showing the aplasia of olfactory bulbs and/or sulci in MRI, it is assumed as differentiation of Kallmann syndrome from isolated hypogonadotropic hypogonadism, in patient without smelling problems or hard to evaluate.
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MRI
- Brain MRI may be helpful in the diagnosis of delayed puberty. Findings on MRI suggestive of delayed puberty include:[1]
- Hypothalamo-pituitary lesions
- Aplasia of olfactory bulb and/or sulci (Kallmann syndrome)
- Optic nerve compression (pituitary adenoma)
- Inner ear abnormalities (CHARGE syndrome)
- Brain MRI is indicated in patients with delayed puberty, experiencing some alarm signs, such as headache, visual impairment, and behavioral changes.
- Showing the aplasia of olfactory bulbs and/or sulci in MRI, it is assumed as differentiation of Kallmann syndrome from isolated hypogonadotropic hypogonadism, in patient without smelling problems or hard to evaluate.[2]
- A moderate agreement is seen between the smell identification test (UPSIT) and presence of the olfactory bulbs in MRI, in patients with hypogonadotropic hypogonadism. While, there is a good agreement between them in absence of the olfactory bulbs in MRI and anosmia.[3][2]
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Pituitary adenoma - Case courtesy of A.Prof Frank Gaillard, <a href="https://radiopaedia.org/">Radiopaedia.org</a>. From the case <a href="https://radiopaedia.org/cases/16890">rID: 16890</a>
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Hypothalamic lesion - Case courtesy of A.Prof Frank Gaillard, <a href="https://radiopaedia.org/">Radiopaedia.org</a>. From the case <a href="https://radiopaedia.org/cases/16890">rID: 16890</a>
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Pituitary non-functioning macroadenoma - Case courtesy of A.Prof Frank Gaillard, <a href="https://radiopaedia.org/">Radiopaedia.org</a>. From the case <a href="https://radiopaedia.org/cases/5562">rID: 5562</a>
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Kallman syndrome difference with normal brain - Case courtesy of A.Prof Frank Gaillard, <a href="https://radiopaedia.org/">Radiopaedia.org</a>. From the case <a href="https://radiopaedia.org/cases/6083">rID: 6083</a>
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References
- ↑ Boehm U, Bouloux PM, Dattani MT, de Roux N, Dodé C, Dunkel L, Dwyer AA, Giacobini P, Hardelin JP, Juul A, Maghnie M, Pitteloud N, Prevot V, Raivio T, Tena-Sempere M, Quinton R, Young J (2015). "Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism--pathogenesis, diagnosis and treatment". Nat Rev Endocrinol. 11 (9): 547–64. doi:10.1038/nrendo.2015.112. PMID 26194704.
- ↑ 2.0 2.1 Palmert, Mark R.; Dunkel, Leo (2012). "Delayed Puberty". New England Journal of Medicine. 366 (5): 443–453. doi:10.1056/NEJMcp1109290. ISSN 0028-4793.
- ↑ Doty RL, Shaman P, Kimmelman CP, Dann MS (1984). "University of Pennsylvania Smell Identification Test: a rapid quantitative olfactory function test for the clinic". Laryngoscope. 94 (2 Pt 1): 176–8. PMID 6694486.