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{{Infobox_gene}}
{{Infobox_gene}}
'''Polymerase (DNA directed) nu''' is a [[protein]] in humans that is encoded by the POLN [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: Polymerase (DNA directed) nu
'''Polymerase (DNA directed) nu''' is a [[protein]] in humans that is encoded by the POLN [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: Polymerase (DNA directed) nu
| url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=353497 }}</ref> It is a [[DNA polymerase#Family A|family A]] [[DNA polymerase]].<ref>{{cite journal | vauthors = Marini F, Kim N, Schuffert A, Wood RD | title = POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 34 | pages = 32014–9 | date = August 2003 | pmid = 12794064 | doi = 10.1074/jbc.M305646200 }}</ref>
| url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=353497 }}</ref> It is a [[DNA polymerase#Family A|family A]] [[DNA polymerase]],<ref>{{cite journal | vauthors = Marini F, Kim N, Schuffert A, Wood RD | title = POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 34 | pages = 32014–9 | date = August 2003 | pmid = 12794064 | doi = 10.1074/jbc.M305646200 }}</ref> considered to be the least effective of the polymerase enzymes.<ref name=uniprot>{{cite web|title=UniProtKB - Q7Z5Q5 (DPOLN_HUMAN)|publisher=Uniprot|url=https://www.uniprot.org/uniprot/Q7Z5Q5|access-date=5 July 2018}}</ref> However, DNA polymerase nu plays an active role in [[homology directed repair|homology repair]] during cellular responses to crosslinks, fulfilling its role in a complex with [[helicase]].<ref name=uniprot />
Polymerase (DNA directed) nu is a protein in humans that is encoded by the POLN gene.[1] It is a family ADNA polymerase,[2] considered to be the least effective of the polymerase enzymes.[3] However, DNA polymerase nu plays an active role in homology repair during cellular responses to crosslinks, fulfilling its role in a complex with helicase.[3]
↑Marini F, Kim N, Schuffert A, Wood RD (August 2003). "POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308". The Journal of Biological Chemistry. 278 (34): 32014–9. doi:10.1074/jbc.M305646200. PMID12794064.
Marini F, Kim N, Schuffert A, Wood RD (August 2003). "POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308". The Journal of Biological Chemistry. 278 (34): 32014–9. doi:10.1074/jbc.M305646200. PMID12794064.
