Crohn's disease classification: Difference between revisions

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==Overview==
==Overview==
Crohn's disease almost invariably affects the [[Gastrointestinal tract|gastrointestinal tract.]] As a result, most gastroenterologists classify the disease by the affected areas and behavior of disease as it progresses. The disease can attack any part of the [[digestive tract]], from [[mouth]] to [[anus]].<ref name="pmid16698746">{{cite journal |vauthors=Satsangi J, Silverberg MS, Vermeire S, Colombel JF |title=The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications |journal=Gut |volume=55 |issue=6 |pages=749–53 |year=2006 |pmid=16698746 |pmc=1856208 |doi=10.1136/gut.2005.082909 |url=}}</ref><ref name="pmid22647554">{{cite journal |vauthors=Vermeire S, Van Assche G, Rutgeerts P |title=Classification of inflammatory bowel disease: the old and the new |journal=Curr. Opin. Gastroenterol. |volume=28 |issue=4 |pages=321–6 |year=2012 |pmid=22647554 |doi=10.1097/MOG.0b013e328354be1e |url=}}</ref><ref name="pmid19786751">{{cite journal |vauthors=Vucelic B |title=Inflammatory bowel diseases: controversies in the use of diagnostic procedures |journal=Dig Dis |volume=27 |issue=3 |pages=269–77 |year=2009 |pmid=19786751 |doi=10.1159/000228560 |url=}}</ref><ref name="pmid17571169">{{cite journal |vauthors=Freeman HJ |title=Application of the Montreal classification for Crohn's disease to a single clinician database of 1015 patients |journal=Can. J. Gastroenterol. |volume=21 |issue=6 |pages=363–6 |year=2007 |pmid=17571169 |pmc=2658118 |doi= |url=}}</ref>
Crohn's disease can affect any part of the [[Gastrointestinal tract|gastrointestinal tract]] expect rectum. Crohn's disease may be classified based on the area of involvement and based on the behavior of the disease progression.


==Classification==
==Classification==
Crohn's disease almost invariably affects the [[gastrointestinal tract]]. As a result, most gastroenterologists classify the disease by the affected areas and behavior of disease as it progresses. The disease can attack any part of the digestive tract, from [[mouth]] to [[anus]]. However, individuals affected by the disease rarely fall outside these three classifications, being affected in other parts of the gastrointestinal tract such as the [[stomach]] and [[esophagus]].
Crohn's disease can affect any part of the [[Gastrointestinal tract|gastrointestinal tract]] expect rectum. It can be classified based on the area of involvement and based on the behavior of the disease progression. Individuals affected by the Crohn's disease rarely fall outside these classifications.
===Based on the region involved===
 
* '''Ileocolic Crohn's disease''', which affects both the [[ileum]] (the last part of the [[small intestine]] that connects to the [[large intestine]]) and the large intestine, accounts for fifty percent of cases.
=== <u>Based on the area of involvement</u> ===
* '''Crohn's ileitis''', affecting the ileum only, accounts for thirty percent of cases.
* '''Ileocolic Crohn's disease'''
* '''Crohn's colitis''', affecting the large intestine, accounts for the remaining twenty percent of cases, and may be particularly difficult to distinguish from [[ulcerative colitis]].
**Crohn's disease involving both the [[ileum]] and the large intestine, accounts for 50% of cases.
===Based on  the behavior of disease===
* '''Crohn's ileitis'''
Crohn's disease may also be classified by the behavior of disease as it progresses. This was formalized in the Vienna classification of Crohn's disease.<ref name=Vienna>{{cite journal | author = Gasche C, Scholmerich J, Brynskov J, D'Haens G, Hanauer S, Irvine E, Jewell D, Rachmilewitz D, Sachar D, Sandborn W, Sutherland L | title = A simple classification of Crohn's disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998 | journal = Inflamm Bowel Dis | volume = 6 | issue = 1 | pages = 8-15 | year = 2000 | id = PMID 10701144}}</ref>  There are three categories of disease presentation in Crohn's disease:
**Crohn's disease involving ileum only, accounts for 30% of cases.
* '''Stricturing disease''' causes narrowing of the bowel which may lead to [[bowel obstruction]] or changes in the caliber of the [[feces]].
* '''Crohn's colitis'''
* '''Penetrating disease''' creates abnormal passageways ([[fistula]]e) between the bowel and other structures such as the skin.
**Crohn's disease involving prendominantly only large intestine. Often  difficult to distinguish from [[ulcerative colitis]].
* '''Inflammatory disease''' (or non-stricturing, non-penetrating disease) causes inflammation without causing [[strictures]] or [[fistulae]].<ref name=Vienna/><ref name=phenotypes>{{cite journal | author = Dubinsky MC, Fleshner PP. | title = Treatment of Crohn's Disease of Inflammatory, Stenotic, and Fistulizing Phenotypes. | journal = Curr Treat Options Gastroenterol | volume = 6 | issue = 3 | pages = 183-200 | year = 2003 | id = PMID 12744819}}</ref>
 
===<u>Based on  the behavior of disease</u>===
Crohn's disease may also be classified by the behavior of disease as it progresses. This was formalized in the Vienna classification of Crohn's disease.<ref name="Vienna">{{cite journal | author = Gasche C, Scholmerich J, Brynskov J, D'Haens G, Hanauer S, Irvine E, Jewell D, Rachmilewitz D, Sachar D, Sandborn W, Sutherland L | title = A simple classification of Crohn's disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998 | journal = Inflamm Bowel Dis | volume = 6 | issue = 1 | pages = 8-15 | year = 2000 | id = PMID 10701144}}</ref>  There are three categories of disease presentation in Crohn's disease:
* '''Stricturing disease'''  
**Causes narrowing of the bowel which may lead to [[bowel obstruction]] or changes in the caliber of the [[feces]].
* '''Penetrating disease'''  
**Creates abnormal passageways ([[fistula]]e) between the bowel and other structures such as the skin.
* '''Inflammatory disease''' (or non-stricturing, non-penetrating disease)
**Causes inflammation without causing [[strictures]] or [[fistulae]].<ref name="Vienna" /><ref name="phenotypes">{{cite journal | author = Dubinsky MC, Fleshner PP. | title = Treatment of Crohn's Disease of Inflammatory, Stenotic, and Fistulizing Phenotypes. | journal = Curr Treat Options Gastroenterol | volume = 6 | issue = 3 | pages = 183-200 | year = 2003 | id = PMID 12744819}}</ref>


==References==
==References==
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{{reflist|2}}
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[[Category:Autoimmune diseases]]
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[[Category:Conditions diagnosed by stool test]]
[[Category:Abdominal pain]]
[[Category:Abdominal pain]]
[[Category:Primary care]]
[[Category:Needs overview]]
[[Category:Needs overview]]
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Latest revision as of 21:10, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Ganti M.B.B.S. [2]

Overview

Crohn's disease can affect any part of the gastrointestinal tract expect rectum. Crohn's disease may be classified based on the area of involvement and based on the behavior of the disease progression.

Classification

Crohn's disease can affect any part of the gastrointestinal tract expect rectum. It can be classified based on the area of involvement and based on the behavior of the disease progression. Individuals affected by the Crohn's disease rarely fall outside these classifications.

Based on the area of involvement

  • Ileocolic Crohn's disease
    • Crohn's disease involving both the ileum and the large intestine, accounts for 50% of cases.
  • Crohn's ileitis
    • Crohn's disease involving ileum only, accounts for 30% of cases.
  • Crohn's colitis
    • Crohn's disease involving prendominantly only large intestine. Often difficult to distinguish from ulcerative colitis.

Based on the behavior of disease

Crohn's disease may also be classified by the behavior of disease as it progresses. This was formalized in the Vienna classification of Crohn's disease.[1] There are three categories of disease presentation in Crohn's disease:

  • Stricturing disease
  • Penetrating disease
    • Creates abnormal passageways (fistulae) between the bowel and other structures such as the skin.
  • Inflammatory disease (or non-stricturing, non-penetrating disease)

References

  1. 1.0 1.1 Gasche C, Scholmerich J, Brynskov J, D'Haens G, Hanauer S, Irvine E, Jewell D, Rachmilewitz D, Sachar D, Sandborn W, Sutherland L (2000). "A simple classification of Crohn's disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998". Inflamm Bowel Dis. 6 (1): 8–15. PMID 10701144.
  2. Dubinsky MC, Fleshner PP. (2003). "Treatment of Crohn's Disease of Inflammatory, Stenotic, and Fistulizing Phenotypes". Curr Treat Options Gastroenterol. 6 (3): 183–200. PMID 12744819.

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