Creutzfeldt-Jakob disease natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Once symptoms develop, Creutzfeldt-Jakob disease is rapidly progressive and almost always fatal. Early symptoms are often non-specific. Patients' relatives usually report rapidly progressive dementia, personality changes, uncontrolled sporadic laughter, and sleep disorders. The majority of patients (85% of patients) die within 1 year of symptom-onset. Common complications of Creutzfeldt-Jakob disease include overwhelming infections, congestive heart failure, or respiratory failure.
Natural History
- Once symptoms develop, Creutzfeldt-Jakob disease is rapidly progressive and almost always fatal.
- Early symptoms are often non-specific. Patients' relatives usually report rapidly progressive dementia, personality changes, uncontrolled sporadic laughter, and sleep disorders.
- The majority of patients (85% of patients) die within 1 year of symptom-onset, often due to complications succh as overwhelming infections, congestive heart failure, or respiratory failure.[1]
Complications
Complications of Creutzfeldt-Jakob disease include the following:
Prognosis
- The prognosis of Creutzfeldt-Jakob disease is very poor.
- Patients usually die within 6 to 12 months of symptom-onset.
- A few reports described individuals surviving beyond than 1 or 2 years after diagnosis.
References
- ↑ "http://www.cdc.gov/ncidod/dvrd/cjd/index.htm". Retrieved 17 February 2014. External link in
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