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==Overview==
==Overview==

Revision as of 17:12, 19 December 2017

Cirrhosis Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Charmaine Patel, M.D. [2]Sudarshana Datta, MD [3]

Overview

Cirrhosis of the liver may be classified using two methods; classification based on etiology, and classification based on morphology. Currently, classifying cirrhosis based on morphology is not used, as it requires an invasive procedure to examine the gross appearance of the liver, and it provides little diagnostic value. Classifying cirrhosis according to etiology is a more acceptable form of classification, as it may be attained through non-invasive laboratory testing, and has a higher diagnostic value.

Classification Based on Etiology

Cirrhosis may be classified on the basis of etiology. This is the most widely accepted method of classification.

Alcoholic Cirrhosis

  • most common cause of cirrhosis
  • caused by continuous and prolonged alcohol abuse
  • According to American Academy of Family Physicians, approximately 60-70 percent of all cases of cirrhosis are due to alcohol abuse

Post-Necrotic Cirrhosis

Biliary Cirrhosis

Cardiac Cirrhosis

Genetic Disorder

Malnutrition

Classification Based on Morphology

Cirrhosis has historically been classified upon the nodular morphology that is seen on upon the gross appearance of the liver. Accurate assessment of the liver morphology can only be obtained through surgery, biopsy, or autopsy, therefore more recently, more non-invasive means of classifying and determining the causes of cirrhosis are used.

Micronodular Macronodular Mixed
Micronodular cirrhosis is characterized by nodules that are less than 3mm in diameter Macronodular cirrhosis is characterized by nodules that are more than 3mm in diameter Micronodular cirrhosis can often progress into macronodular cirrhosis. During this transformation, a mixed form of cirrhosis may be seen.[1]
Causes:

 Causes:

Mixed nodular cirrhosis is also seen in Indian childhood cirrhosis. [2]

References

  1. Fauerholdt L, Schlichting P, Christensen E, Poulsen H, Tygstrup N, Juhl E (1983). "Conversion of micronodular cirrhosis into macronodular cirrhosis". Hepatology. 3 (6): 928–31. PMID 6629323.
  2. Nayak NC, Ramalingaswami V (1975). "Indian childhood cirrhosis". Clin Gastroenterol. 4 (2): 333–49. PMID 47794.

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