Chronic stable angina perfusion scintigraphy with pharmacologic stress
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Chronic stable angina Microchapters | ||
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Differentiating Chronic Stable Angina from Acute Coronary Syndromes | ||
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Editors-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753; Cafer Zorkun, M.D., Ph.D. [2]; Associate Editor-in-Chief: Smita Kohli, M.D.
Perfusion Scintigraphy with Pharmacologic Stress
- Many patients with known or suspected angina pectoris are unable to perform adequate exercise tests owing to peripheral vascular disease, musculoskeletal disorders, diseases of the lower extremities, severe obesity, or deconditioning. Myocardial perfusion scintigraphy during pharmacologic stress can be employed in these groups of patients.
- Non endothelium dependent coronary vasodilators such as dipyridamole or adenosine can be used to increase flow to the non ischemic myocardial segments. During the test they produce perfusion defects in ischemic areas that can be detected by scintigraphy.
- Alternatively, dobutamine can be used to increase heart rate and contractility, which increases myocardial oxygen demand, and this too may compromise perfusion of ischemic areas; the resultant ischemia can be detected by perfusion scintigraphy. Dobutamine may cause true myocardial ischemia, not simply a relative increase in flow to nonischemic myocardium. Hence, it must be administered carefully with close monitoring and rapid cessation for potential symptomatic ischemia.
- All three of these pharmacologic stress tests have diagnostic accuracies (sensitivity, specificity, and predictive values) comparable with those of exercise perfusion scintigraphy.
- Both dipyridamole and adenosine produce similar side effects, which consist of bronchospasm, flushing, dizziness, headache, nausea, atypical chest pain, and throat or jaw pain.
- Dipyridamole infusion has been reported to induce severe myocardial ischemia and, rarely, myocardial infarction.
- Adenosine, on the other hand, can produce significant bradyarrhythmias. Adenosine stress tests are therefore contraindicated in patients with atrioventricular block and sick sinus syndrome.
ACC / AHA Guidelines- Cardiac Stress Imaging as the Initial Test for Diagnosis in Patients With Chronic Stable Angina Who Are Unable to Exercise (DO NOT EDIT)[1]
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Class I1. Adenosine or dipyridamole myocardial perfusion imaging or dobutamine echocardiography in patients with an intermediate pretest probability of CAD. (Level of Evidence: B) 2. Adenosine or dipyridamole stress myocardial perfusion imaging or dobutamine echocardiography in patients with prior revascularization (either PTCA or CABG). (Level of Evidence: B) Class IIb1. Adenosine or dipyridamole stress myocardial perfusion imaging or dobutamine echocardiography in patients with a low or high probability of CAD in the absence of electronically paced ventricular rhythm or left bundle-branch block. (Level of Evidence: B) 2. Adenosine or dipyridamole myocardial perfusion imaging in patients with a low or high probability of CAD and 1 of the following baseline ECG abnormalities:
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ESC Guidelines for the use of exercise stress with imaging techniques (either echocardiography or perfusion) in the initial diagnostic assessment of angina (DO NOT EDIT)[2]
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Class I1. Patients with resting ECG abnormalities, LBBB, more than 1 mm ST-depression, paced rhythm, or WPW which prevent 12 ESC Guidelines accurate interpretation of ECG changes during stress. (Level of Evidence: B) 2. Patients with a non-conclusive exercise ECG but reasonable exercise tolerance, who do not have a high probability of significant coronary artery disease and in whom the diagnosis is still in doubt. (Level of Evidence: B) Class IIa1. Patients with prior revascularization (PCI or CABG) in whom localization of ischaemia is important. (Level of Evidence: B) 2. As an alternative to exercise ECG in patients where facilities, cost, and personnel resources allow. (Level of Evidence: B) 3. As an alternative to exercise ECG in patients with a low pre-test probability of disease such as women with atypical chest pain. (Level of Evidence: B) 4. To assess functional severity of intermediate lesions on coronary arteriography. (Level of Evidence: C) 5. To localize ischaemia when planning revascularization options in patients who have already had arteriography. (Level of Evidence: B) |
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See Also
Sources
- Guidelines on the management of stable angina pectoris: The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology [2]
- The ACC/AHA/ACP–ASIM Guidelines for the Management of Patients With Chronic Stable Angina [1]
- TheACC/AHA 2002 Guideline Update for the Management of Patients With Chronic Stable Angina [3]
- The 2007 Chronic Angina Focused Update of the ACC/AHA 2002 Guidelines for the Management of Patients With Chronic Stable Angina [4]
References
- ↑ 1.0 1.1 Gibbons RJ, Chatterjee K, Daley J, Douglas JS, Fihn SD, Gardin JM et al. (1999) ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: executive summary and recommendations. A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients with Chronic Stable Angina). Circulation 99 (21):2829-48. PMID: 10351980
- ↑ 2.0 2.1 Fox K, Garcia MA, Ardissino D, Buszman P, Camici PG, Crea F; et al. (2006). "Guidelines on the management of stable angina pectoris: executive summary: The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology". Eur Heart J. 27 (11): 1341–81. doi:10.1093/eurheartj/ehl001. PMID 16735367.
- ↑ Gibbons RJ, Abrams J, Chatterjee K, Daley J, Deedwania PC, Douglas JS et al. (2003) ACC/AHA 2002 guideline update for the management of patients with chronic stable angina--summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Chronic Stable Angina). Circulation 107 (1):149-58. PMID: 12515758
- ↑ Fraker TD, Fihn SD, Gibbons RJ, Abrams J, Chatterjee K, Daley J et al. (2007) 2007 chronic angina focused update of the ACC/AHA 2002 Guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines Writing Group to develop the focused update of the 2002 Guidelines for the management of patients with chronic stable angina. Circulation 116 (23):2762-72. DOI:10.1161/CIRCULATIONAHA.107.187930 PMID: 17998462