Cancer of unknown primary origin medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

There is no treatment for cancer of unknown primary origin; the mainstay of therapy is supportive care.

Medical Therapy

Medical Therapy

  • There is no treatment for cancer of unknown primary origin; the mainstay of therapy is supportive care.[1]
  • The treatment for cancer of unknown primary origin will depend on several factors, such as metastatic origin, biopsy findings, patients age, and performance status.
  • Medical therapy for cancer of unknown primary origin should be adjusted on an individual basis and according to well-defined clinicopathologic subsets.[1]
  • The table below summarizes different types of medical therapy strategies for cancer of unknown primary origin.
Treatment for cancer of unknown primary origin

Adapted from the European Society of Medical Oncology[1]

Sub-type Proposed treatment

Poorly differentiated carcinoma, predominately nodal disease

Platinum based combination chemotherapy

Peritoneal carcinomatosis in female

Platinum based chemotherapy

Isolated axillary nodal metastases in female

Identical to breast cancer with similar nodal involvement

Squamous carcinoma of cervical lymph nodes

Irradiation for N1-N2 disease.
For higher stages induction chemotherapy with platinum-based combination is suggested

Liver, bone, or multiple-site metastases of adenocarcinoma

Low toxicity chemotherapy of palliative orientation or best supportive care are acceptable

References

  1. 1.0 1.1 1.2 Briasoulis E, Tolis C, Bergh J, Pavlidis N (2005). "ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of cancers of unknown primary site (CUP)". Ann. Oncol. 16 Suppl 1: i75–6. doi:10.1093/annonc/mdi804. PMID 15888766.

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