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{{Infobox_gene}}
{{PBB_Controls
'''Coatomer subunit gamma''' is a [[protein]] that in humans is encoded by the ''COPG'' [[gene]].<ref name="pmid11056392">{{cite journal |vauthors=Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K | title = Identification and characterization of novel isoforms of COP I subunits | journal = J Biochem | volume = 128 | issue = 5 | pages = 793–801 | date=February 2001| pmid = 11056392 | pmc =  | doi =  10.1093/oxfordjournals.jbchem.a022817}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: COPG coatomer protein complex, subunit gamma| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22820| accessdate = }}</ref> It is one of seven proteins in the [[COPI]] coatomer complex that coats vesicles as they bud from the [[Golgi Apparatus|Golgi]] complex.<ref name="pmid11056392"/>
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| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Interactions==
{{GNF_Protein_box
COPG has been shown to [[Protein-protein interaction|interact]] with [[Dopamine receptor D1]],<ref name=pmid11893085>{{cite journal |last=Bermak |first=Jason C |authorlink= |author2=Li Ming |author3=Bullock Clayton |author4=Weingarten Paul |author5=Zhou Qun-Yong |date=February 2002|title=Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus |journal=Eur. J. Cell Biol. |volume=81 |issue=2 |pages=77–85 |publisher= |location = Germany| issn = 0171-9335| pmid = 11893085 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1078/0171-9335-00222 }}</ref> [[COPZ1]]<ref name=pmid11056392/><ref name=pmid8858162>{{cite journal |last=Faulstich |first=D |authorlink= |author2=Auerbach S|author3=Orci L|author4=Ravazzola M|author5=Wegchingel S|author6=Lottspeich F|author7=Stenbeck G|author8=Harter C|author9=Wieland F T|author10=Tschochner H |date=October 1996|title=Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex |journal=J. Cell Biol. |volume=135 |issue=1 |pages=53–61 |publisher= |location = UNITED STATES| issn = 0021-9525| pmid = 8858162 | bibcode = | oclc =| id = | url = http://jcb.rupress.org/content/jcb/135/1/53.full.pdf| language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1083/jcb.135.1.53 |pmc=2121028 }}</ref> and [[COPB1]].<ref name="pmid11056392"/><ref name=pmid8940050>{{cite journal |last=Lowe |first=M |authorlink= |author2=Kreis T E |date=November 1996|title=In vivo assembly of coatomer, the COP-I coat precursor |journal=J. Biol. Chem. |volume=271 |issue=48 |pages=30725–30 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 8940050 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.271.48.30725 }}</ref>
| image = PBB_Protein_COPG_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1pzd.
| PDB = {{PDB2|1pzd}}, {{PDB2|1r4x}}
  | Name = Coatomer protein complex, subunit gamma
| HGNCid = 2236
| Symbol = COPG
| AltSymbols =; COPG1; FLJ21068
| OMIM =
| ECnumber =
| Homologene = 56745
| MGIid = 1858696
| GeneAtlas_image1 = PBB_GE_COPG_217749_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005488 |text = binding}}
| Component = {{GNF_GO|id=GO:0005905 |text = coated pit}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0030126 |text = COPI vesicle coat}}
| Process = {{GNF_GO|id=GO:0006890 |text = retrograde vesicle-mediated transport, Golgi to ER}} {{GNF_GO|id=GO:0006891 |text = intra-Golgi vesicle-mediated transport}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 22820
    | Hs_Ensembl = ENSG00000181789
    | Hs_RefseqProtein = NP_057212
    | Hs_RefseqmRNA = NM_016128
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 130451143
    | Hs_GenLoc_end = 130479304
    | Hs_Uniprot = Q9Y678
    | Mm_EntrezGene = 54161
    | Mm_Ensembl = ENSMUSG00000030058
    | Mm_RefseqmRNA = NM_017477
    | Mm_RefseqProtein = NP_059505
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 87853581
    | Mm_GenLoc_end = 87879236
    | Mm_Uniprot =
  }}
}}
'''Coatomer protein complex, subunit gamma''', also known as '''COPG''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: COPG coatomer protein complex, subunit gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22820| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==References==
{{PBB_Summary
{{reflist}}
| section_title =  
 
| summary_text =
==External links==
}}
* {{UCSC gene info|COPG1}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  |vauthors=Lowe M, Kreis TE |title=In vivo assembly of coatomer, the COP-I coat precursor. |journal=J. Biol. Chem. |volume=271 |issue= 48 |pages= 30725–30 |year= 1997 |pmid= 8940050 |doi=10.1074/jbc.271.48.30725 }}
| citations =
*{{cite journal  |vauthors=Pavel J, Harter C, Wieland FT |title=Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 5 |pages= 2140–5 |year= 1998 |pmid= 9482852 |doi=10.1073/pnas.95.5.2140  | pmc=19276  |bibcode=1998PNAS...95.2140P }}
*{{cite journal  | author=Lowe M, Kreis TE |title=In vivo assembly of coatomer, the COP-I coat precursor. |journal=J. Biol. Chem. |volume=271 |issue= 48 |pages= 30725-30 |year= 1997 |pmid= 8940050 |doi=  }}
*{{cite journal  |vauthors=Fischer KD, Helms JB, Zhao L, Wieland FT |title=Site-specific photocrosslinking to probe interactions of Arf1 with proteins involved in budding of COPI vesicles. |journal=Methods |volume=20 |issue= 4 |pages= 455–64 |year= 2000 |pmid= 10720466 |doi= 10.1006/meth.2000.0958 }}
*{{cite journal  | author=Pavel J, Harter C, Wieland FT |title=Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 5 |pages= 2140-5 |year= 1998 |pmid= 9482852 |doi= }}
*{{cite journal  |vauthors=Eugster A, Frigerio G, Dale M, Duden R |title=COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP. |journal=EMBO J. |volume=19 |issue= 15 |pages= 3905–17 |year= 2000 |pmid= 10921873 |doi= 10.1093/emboj/19.15.3905 | pmc=306616 }}
*{{cite journal  | author=Fischer KD, Helms JB, Zhao L, Wieland FT |title=Site-specific photocrosslinking to probe interactions of Arf1 with proteins involved in budding of COPI vesicles. |journal=Methods |volume=20 |issue= 4 |pages= 455-64 |year= 2000 |pmid= 10720466 |doi= 10.1006/meth.2000.0958 }}
*{{cite journal  |vauthors=Hu RM, Han ZG, Song HD |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 | pmc=16901 |display-authors=etal|bibcode=2000PNAS...97.9543H }}
*{{cite journal  | author=Eugster A, Frigerio G, Dale M, Duden R |title=COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP. |journal=EMBO J. |volume=19 |issue= 15 |pages= 3905-17 |year= 2000 |pmid= 10921873 |doi= 10.1093/emboj/19.15.3905 }}
*{{cite journal  |vauthors=Sullivan BM, Harrison-Lavoie KJ, Marshansky V |title=RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport. |journal=Mol. Biol. Cell |volume=11 |issue= 9 |pages= 3155–68 |year= 2000 |pmid= 10982407 |doi=  10.1091/mbc.11.9.3155| pmc=14982  |display-authors=etal}}
*{{cite journal  | author=Hu RM, Han ZG, Song HD, ''et al.'' |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543-8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 }}
*{{cite journal  |vauthors=Hahn Y, Lee YJ, Yun JH |title=Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate, insect and plant evolution. |journal=FEBS Lett. |volume=482 |issue= 1–2 |pages= 31–6 |year= 2000 |pmid= 11018518 |doi=10.1016/S0014-5793(00)02033-0  |display-authors=etal}}
*{{cite journal  | author=Sullivan BM, Harrison-Lavoie KJ, Marshansky V, ''et al.'' |title=RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport. |journal=Mol. Biol. Cell |volume=11 |issue= 9 |pages= 3155-68 |year= 2000 |pmid= 10982407 |doi=  }}
*{{cite journal  |vauthors=Paulsson KM, Kleijmeer MJ, Griffith J |title=Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum |journal=J. Biol. Chem. |volume=277 |issue= 21 |pages= 18266–71 |year= 2002 |pmid= 11884415 |doi= 10.1074/jbc.M201388200 |display-authors=etal}}
*{{cite journal  | author=Hahn Y, Lee YJ, Yun JH, ''et al.'' |title=Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate, insect and plant evolution. |journal=FEBS Lett. |volume=482 |issue= 1-2 |pages= 31-6 |year= 2000 |pmid= 11018518 |doi= }}
*{{cite journal  |vauthors=Bermak JC, Li M, Bullock C |title=Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus |journal=Eur. J. Cell Biol. |volume=81 |issue= 2 |pages= 77–85 |year= 2002 |pmid= 11893085 |doi=10.1078/0171-9335-00222  |display-authors=etal}}
*{{cite journal  | author=Futatsumori M, Kasai K, Takatsu H, ''et al.'' |title=Identification and characterization of novel isoforms of COP I subunits. |journal=J. Biochem. |volume=128 |issue= 5 |pages= 793-801 |year= 2001 |pmid= 11056392 |doi= }}
*{{cite journal  |vauthors=Kanzaki M, Watson RT, Hou JC |title=Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes |journal=Mol. Biol. Cell |volume=13 |issue= 7 |pages= 2334–46 |year= 2003 |pmid= 12134073 |doi= 10.1091/mbc.01-10-0490  | pmc=117317 |display-authors=etal}}
*{{cite journal  | author=Paulsson KM, Kleijmeer MJ, Griffith J, ''et al.'' |title=Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum. |journal=J. Biol. Chem. |volume=277 |issue= 21 |pages= 18266-71 |year= 2002 |pmid= 11884415 |doi= 10.1074/jbc.M201388200 }}
*{{cite journal  |vauthors=Xu Y, Martin S, James DE, Hong W |title=GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus |journal=Mol. Biol. Cell |volume=13 |issue= 10 |pages= 3493–507 |year= 2003 |pmid= 12388752 |doi= 10.1091/mbc.E02-01-0004  | pmc=129961 }}
*{{cite journal  | author=Bermak JC, Li M, Bullock C, ''et al.'' |title=Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus. |journal=Eur. J. Cell Biol. |volume=81 |issue= 2 |pages= 77-85 |year= 2002 |pmid= 11893085 |doi= }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Kanzaki M, Watson RT, Hou JC, ''et al.'' |title=Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes. |journal=Mol. Biol. Cell |volume=13 |issue= 7 |pages= 2334-46 |year= 2003 |pmid= 12134073 |doi= 10.1091/mbc.01-10-0490 }}
*{{cite journal  |vauthors=Rohde HM, Cheong FY, Konrad G |title=The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52689–99 |year= 2004 |pmid= 14527956 |doi= 10.1074/jbc.M307983200 |display-authors=etal}}
*{{cite journal  | author=Xu Y, Martin S, James DE, Hong W |title=GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus. |journal=Mol. Biol. Cell |volume=13 |issue= 10 |pages= 3493-507 |year= 2003 |pmid= 12388752 |doi= 10.1091/mbc.E02-01-0004 }}
*{{cite journal  |vauthors=Watson PJ, Frigerio G, Collins BM |title=Gamma-COP appendage domain - structure and function |journal=Traffic |volume=5 |issue= 2 |pages= 79–88 |year= 2004 |pmid= 14690497 |doi=10.1111/j.1600-0854.2004.00158.x  |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Rohde HM, Cheong FY, Konrad G, ''et al.'' |title=The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52689-99 |year= 2004 |pmid= 14527956 |doi= 10.1074/jbc.M307983200 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Watson PJ, Frigerio G, Collins BM, ''et al.'' |title=Gamma-COP appendage domain - structure and function. |journal=Traffic |volume=5 |issue= 2 |pages= 79-88 |year= 2004 |pmid= 14690497 |doi= }}
*{{cite journal  |vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=22820}}
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{{Vesicular transport proteins}}
 
 
{{gene-3-stub}}

Latest revision as of 14:18, 4 November 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Coatomer subunit gamma is a protein that in humans is encoded by the COPG gene.[1][2] It is one of seven proteins in the COPI coatomer complex that coats vesicles as they bud from the Golgi complex.[1]

Interactions

COPG has been shown to interact with Dopamine receptor D1,[3] COPZ1[1][4] and COPB1.[1][5]

References

  1. 1.0 1.1 1.2 1.3 Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K (February 2001). "Identification and characterization of novel isoforms of COP I subunits". J Biochem. 128 (5): 793–801. doi:10.1093/oxfordjournals.jbchem.a022817. PMID 11056392.
  2. "Entrez Gene: COPG coatomer protein complex, subunit gamma".
  3. Bermak, Jason C; Li Ming; Bullock Clayton; Weingarten Paul; Zhou Qun-Yong (February 2002). "Interaction of gamma-COP with a transport motif in the D1 receptor C-terminus". Eur. J. Cell Biol. Germany. 81 (2): 77–85. doi:10.1078/0171-9335-00222. ISSN 0171-9335. PMID 11893085.
  4. Faulstich, D; Auerbach S; Orci L; Ravazzola M; Wegchingel S; Lottspeich F; Stenbeck G; Harter C; Wieland F T; Tschochner H (October 1996). "Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex" (PDF). J. Cell Biol. UNITED STATES. 135 (1): 53–61. doi:10.1083/jcb.135.1.53. ISSN 0021-9525. PMC 2121028. PMID 8858162.
  5. Lowe, M; Kreis T E (November 1996). "In vivo assembly of coatomer, the COP-I coat precursor". J. Biol. Chem. UNITED STATES. 271 (48): 30725–30. doi:10.1074/jbc.271.48.30725. ISSN 0021-9258. PMID 8940050.

External links

Further reading