Bronchitis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Bronchitis is an inflammation of the bronchi (medium-size airways) in the lungs. Acute bronchitis is usually caused by viruses or bacteria and may last several days or weeks. Chronic bronchitis is not necessarily caused by infection and is generally part of a syndrome called chronic obstructive pulmonary disease (COPD); it is defined clinically as a persistent cough that produces sputum (phlegm), for at least three months in two consecutive years. The remainder of this article deals with acute bronchitis only. This is caused by a viral infection, such as a cold, or a bacterial infection. It also can result from breathing irritating fumes, such as those of tobacco smoke or polluted air. Constant coughing is the main symptom. Either type(chronic or acute) may lead to asthma or pneumonia.
Acute bronchitis is characterized by cough and sputum (phlegm) production and symptoms related to the obstruction of the airways by the inflamed airways and the phlegm, such as shortness of breath and wheezing. Diagnosis is by clinical examination and sometimes microbiological examination of the phlegm. Treatment may be with antibiotics (if a bacterial infection is suspected), bronchodilators (to relieve breathlessness) and other treatments.
Signs and symptoms
Bronchitis may be indicated by an expectorating cough,shortness of breath (dyspnea) and wheezing and occasionally chest pains, fever, and fatigue or malaise.
Diagnosis
A physical examination will often reveal decreased intensity of breath sounds, wheeze (rhonchi) and prolonged expiration. Most doctors rely on the presence of a persistent dry or wet cough as evidence of bronchitis.
A variety of tests may be performed in patients presenting with cough and shortness of breath:
- A chest X-ray that reveals hyperinflation; collapse and consolidation of lung areas would support a diagnosis of pneumonia. Some conditions that predispose to bronchitis may be indicated by chest radiography.
- A sputum sample showing neutrophil granulocytes (inflammatory white blood cells) and culture showing that has pathogenic microorganisms such as Streptococcus spp.
- A blood test would indicate inflammation (as indicated by a raised white blood cell count and elevated C-reactive protein).
- Neutrophils infiltrate the lung tissue, aided by damage to the airways caused by irritation.
- Damage caused by irritation of the airways leads to inflammation and leads to neutrophils being present
- Mucosal hypersecretion is promoted by a substance released by neutrophils
- Further obstruction to the airways is caused by more goblet cells in the small airways. This is typical of chronic bronchitis
- Although infection is not the reason or cause of chronic bronchitis it is seen to aid in sustaining the bronchitis.
Treatment
Antibiotics
In most cases, acute bronchitis is caused by viruses, not bacteria and it will go away on its own without antibiotics. To treat acute bronchitis that appears to be caused by a bacterial infection, or as a precaution, antibiotics may be given.[1]
If antibiotics are used, a meta-analysis found that "amoxicillin/clavulanic acid, macrolides, second-generation or third-generation cephalosporins, and quinolones" may be more effective.[2]
Smoking cessation
To help the bronchial tree heal faster and not make bronchitis worse, smokers should completely quit smoking. [3]
Prognosis
Acute bronchitis usually lasts approximately 20 or 30 days. It may accompany or closely follow a cold or the flu, or may occur on its own. Bronchitis usually begins with a dry cough, including waking the sufferer at night. After a few days it progresses to a wetter or productive cough, which may be accompanied by fever, fatigue, and headache. The fever, fatigue, and malaise may last only a few days; but the wet cough may last up to several weeks.
Should the cough last longer than a month, some doctors may issue a referral to an otolaryngologist (ear, nose and throat doctor) to see if a condition other than bronchitis is causing the irritation. It is possible that having irritated bronchial tubes for as long as a few months may inspire asthmatic conditions in some patients.
In addition, if one starts coughing mucus tinged with blood, one should see a doctor. In rare cases, doctors may conduct tests to see if the cause is a serious condition such as tuberculosis or lung cancer.
Prevention
In 1985, University of Newcastle, Australia Professor Robert Clancy developed an oral vaccine for acute bronchitis. This vaccine was commercialised four years later as Broncostat.[3]
References
- ↑ The Merck Manual of Medical Information: Bronchitis. February 2003. Accessed 20 March 2007.
- ↑ Dimopoulos G, Siempos II, Korbila IP, Manta KG, Falagas ME (2007). "Comparison of first-line with second-line antibiotics for acute exacerbations of chronic bronchitis: a metaanalysis of randomized controlled trials to Joe Fo Sho". Chest. 132 (2): 447–55. doi:10.1378/chest.07-0149. PMID 17573508.
- ↑ The American Academy of Family Physicians: Acute Bronchitis. January 2006. Accessed 20 March 2007.
External links
Online medical references:
- Bronchitis Lungs OnLine
- Acute Bronchitis FamilyDoctor.org (American Academy of Family Physicians)
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