Brodie abscess pathophysiology: Difference between revisions
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Local [[trauma]] and [[bacteremia]] lead to increased susceptibility to bacterial seeding of the [[metaphysis]]. History of trauma is reported in 30% of patients. | Local [[trauma]] and [[bacteremia]] lead to increased susceptibility to bacterial seeding of the [[metaphysis]]. History of trauma is reported in 30% of patients. | ||
==Pathophysiology== | ==Pathophysiology== | ||
*Local [[trauma]] and [[bacteremia]] lead to increased susceptibility to bacterial seeding of the [[metaphysis]]. History of trauma is reported in 30% of patients. | *Local [[trauma]] and [[bacteremia]] lead to increased susceptibility to bacterial seeding of the [[metaphysis]]. History of [[trauma]] is reported in 30% of patients. Brodie abscess arises where the [[bacteria]] and the [[host]] [[defenses]] are equally balanced. To reduce the [[systemic]] response, the abscess is walled-off. An [[osseous]] [[infection]] can be caused by [[hematogenous]] spread of [[pathogens]] to bone or by direct inoculations by bacteria. The [[organisms]] reach the bone from a disrupted site else where in the body such as a [[skin]] [[pustule]], [[furuncles]], [[impetigo]], infected [[blisters]] and [[burns]], or secondary to an infection of another organ system ([[urogenital]] [[infections]], [[enteritis]], [[cholangitis]] or [[endocarditis]]. <ref name="pmidDOI:10.5334/jbr-btr.145">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=DOI:10.5334/jbr-btr.145 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10 }} </ref> | ||
== References == | == References == | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 08:12, 4 February 2023
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdulkerim Yassin, M.B.B.S[2]
Overview
Local trauma and bacteremia lead to increased susceptibility to bacterial seeding of the metaphysis. History of trauma is reported in 30% of patients.
Pathophysiology
- Local trauma and bacteremia lead to increased susceptibility to bacterial seeding of the metaphysis. History of trauma is reported in 30% of patients. Brodie abscess arises where the bacteria and the host defenses are equally balanced. To reduce the systemic response, the abscess is walled-off. An osseous infection can be caused by hematogenous spread of pathogens to bone or by direct inoculations by bacteria. The organisms reach the bone from a disrupted site else where in the body such as a skin pustule, furuncles, impetigo, infected blisters and burns, or secondary to an infection of another organ system (urogenital infections, enteritis, cholangitis or endocarditis. [1]
References
- ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID DOI:10.5334/jbr-btr.145 Check
|pmid=value (help).