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[[Breast lumps]] may be classified according to [[epithelial]] [[hyperplasia]] into 3 subtypes: non-proliferative, proliferative disease and proliferative disease without [[atypia]].
[[Breast lumps]] may be classified according to [[epithelial]] [[hyperplasia]] into 3 subtypes: non-proliferative, proliferative disease and proliferative disease without [[atypia]]. [[Breast lumps]] may be classified into 3 sub-types based on [[histological]] regions: [[lobular]] region, ductal region, different origins.
 
[[Breast lumps]] may be classified into 3 subtypes based on [[histological]] regions: [[lobular]] region, ductal region, different origins.


==Classification==
==Classification==


'''Classification of [[breast lumps]] based on [[epithelial hyperplasia]]<ref name="pmid16034008">{{cite journal| author=Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K et al.| title=Benign breast disease and the risk of breast cancer. | journal=N Engl J Med | year= 2005 | volume= 353 | issue= 3 | pages= 229-37 | pmid=16034008 | doi=10.1056/NEJMoa044383 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16034008  }} </ref>'''<ref name="pmid1734106">{{cite journal| author=London SJ, Connolly JL, Schnitt SJ, Colditz GA| title=A prospective study of benign breast disease and the risk of breast cancer. | journal=JAMA | year= 1992 | volume= 267 | issue= 7 | pages= 941-4 | pmid=1734106 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1734106  }}</ref>
'''Classification of breast lumps based on epithelial hyperplasia:'''<ref name="pmid16034008">{{cite journal| author=Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K et al.| title=Benign breast disease and the risk of breast cancer. | journal=N Engl J Med | year= 2005 | volume= 353 | issue= 3 | pages= 229-37 | pmid=16034008 | doi=10.1056/NEJMoa044383 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16034008  }} </ref><ref name="pmid1734106">{{cite journal| author=London SJ, Connolly JL, Schnitt SJ, Colditz GA| title=A prospective study of benign breast disease and the risk of breast cancer. | journal=JAMA | year= 1992 | volume= 267 | issue= 7 | pages= 941-4 | pmid=1734106 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1734106 }}</ref><ref name="pmid39659322">{{cite journal| author=Dupont WD, Page DL| title=Risk factors for breast cancer in women with proliferative breast disease. | journal=N Engl J Med | year= 1985 | volume= 312 | issue= 3 | pages= 146-51 | pmid=3965932 | doi=10.1056/NEJM198501173120303 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3965932 }}</ref>
*Approximately 65% of all benign breast disease considered as [[nonproliferative|non-proliferative]] (NP) with relative cancer risk of 1.2, 1.4 times:
*Approximately 65% of all benign breast disease considered as non-proliferative (NP) with relative cancer risk of 1.2 - 1.4 times:
**Simple [[cyst]]
**[[Cyst]] (most common)<ref name="pmid7110289">{{cite journal| author=Love SM, Gelman RS, Silen W| title=Sounding board. Fibrocystic "disease" of the breast--a nondisease? | journal=N Engl J Med | year= 1982 | volume= 307 | issue= 16 | pages= 1010-4 | pmid=7110289 | doi=10.1056/NEJM198210143071611 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7110289  }} </ref>
**[[Fibrosis]]
**[[Fibrosis]]
** [[Fibroadenoma]] (simple)
** [[Fibroadenoma]] (simple)
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** [[Apocrine]] [[metaplasia]] (simple)
** [[Apocrine]] [[metaplasia]] (simple)
** Mild ductal [[hyperplasia]]  
** Mild ductal [[hyperplasia]]  
* Approximately 30% of total are classified as (PD) with relative cancer risk of 1.7, 2.1 times
* Approximately 30% of total are classified as proliferative disease (PD) with relative cancer risk of 1.7 - 2.1 times:<ref name="pmid3965932">{{cite journal| author=Dupont WD, Page DL| title=Risk factors for breast cancer in women with proliferative breast disease. | journal=N Engl J Med | year= 1985 | volume= 312 | issue= 3 | pages= 146-51 | pmid=3965932 | doi=10.1056/NEJM198501173120303 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3965932  }}</ref>
** Usual ductal [[hyperplasia]]
** Usual ductal [[hyperplasia]]
**  Sclerosing adenosis
**  [[Sclerosing adenosis]]
** Columnar [[hyperplasia]]  
** Columnar [[hyperplasia]]  
** [[papilloma]]
** [[Papilloma]]
** Radical scar
** Radical scar
* Approximately 5% to 8% of the rest regarded to PD with [[atypia]] and relative cancer risk more than 4 times
* Approximately 5% to 8% of the rest are regarded as PD with [[atypia]] and relative cancer risk more than 4 times:<ref name="pmid6275978">{{cite journal| author=Page DL, Dupont WD, Rogers LW, Landenberger M| title=Intraductal carcinoma of the breast: follow-up after biopsy only. | journal=Cancer | year= 1982 | volume= 49 | issue= 4 | pages= 751-8 | pmid=6275978 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6275978  }}</ref>
** Atypical lobar [[hyperplasia]]
** Atypical lobar [[hyperplasia]]
** [[Lobular]] [[carcinoma]] [[in situ]]
** [[Lobular]] [[carcinoma]] [[in situ]]
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** [[Apocrine]] [[atypia]]
** [[Apocrine]] [[atypia]]
** Secretory [[atypia]]
** Secretory [[atypia]]
'''Classification of [[benign breast lesion]] regarding to [[histological region|histologist region]]''':<ref>{{cite book | last = Lanyi | first = M | title = Mammography : diagnosis and pathological analysis | publisher = Springer-Verlag | location = Berlin New York | year = 2003 | isbn = 9783540441137 }}</ref>
'''Classification of [[benign breast lesion]] according to histological region''':<ref>{{cite book | last = Lanyi | first = M | title = Mammography : diagnosis and pathological analysis | publisher = Springer-Verlag | location = Berlin New York | year = 2003 | isbn = 9783540441137 }}</ref>
*Terminal and [[lobular]] ducts
*Terminal and [[lobular]] ducts
**[[Acinar]] distention  
**[[Acinar]] distention  
***[[Cyst]]
***[[Cyst]]
**Intralobular connective tissue proliferation
**Intralobular connective tissue proliferation
***Sclerosing adenosis
***[[Sclerosing adenosis]]
***[[Fibroadenoma]]
***[[Fibroadenoma]]
***[[Phyllodes tumor]]
***[[Phyllodes tumor]]
***[[Hamartoma]]
***[[Hamartoma]]
**Epithelial changes in terminal duct [[lobular]] units (TDLU)
**[[Epithelial]] changes in terminal duct [[lobular]] units (TDLU)
***[[Apocrine]] [[metaplasia]]
***[[Apocrine]] [[metaplasia]]
***Ductal and [[lobular]] [[hyperplasia]], usual and typical
***Ductal and [[lobular]] [[hyperplasia]], usual and typical
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**[[Fibrous]] tissue lesions
**[[Fibrous]] tissue lesions
***Focal [[fibrosis]]
***Focal [[fibrosis]]
***[[Diabetic]] mastopathy
***[[Diabetic]] mastopathy or lymphocytic mastitis or lymphocytic mastopathy<ref name="pmid16297091">{{cite journal| author=Lai EC, Chan WC, Ma TK, Tang AP, Poon CS, Leong HT| title=The role of conservative treatment in idiopathic granulomatous mastitis. | journal=Breast J | year= 2005 | volume= 11 | issue= 6 | pages= 454-6 | pmid=16297091 | doi=10.1111/j.1075-122X.2005.00127.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16297091  }}</ref><ref name="pmid11772912">{{cite journal| author=Kudva YC, Reynolds C, O'Brien T, Powell C, Oberg AL, Crotty TB| title="Diabetic mastopathy," or sclerosing lymphocytic lobulitis, is strongly associated with type 1 diabetes. | journal=Diabetes Care | year= 2002 | volume= 25 | issue= 1 | pages= 121-6 | pmid=11772912 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11772912  }}</ref>
***Pseudoangiomatous [[stromal]] [[hyperplasia]] (PASH)
***Pseudoangiomatous [[stromal]] [[hyperplasia]] (PASH)
***Myofibroblastoma
***Myofibroblastoma
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==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
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Latest revision as of 20:42, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shadan Mehraban, M.D.[2]

Overview

Breast lumps may be classified according to epithelial hyperplasia into 3 subtypes: non-proliferative, proliferative disease and proliferative disease without atypia. Breast lumps may be classified into 3 sub-types based on histological regions: lobular region, ductal region, different origins.

Classification

Classification of breast lumps based on epithelial hyperplasia:[1][2][3]

Classification of benign breast lesion according to histological region:[7]

References

  1. Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K; et al. (2005). "Benign breast disease and the risk of breast cancer". N Engl J Med. 353 (3): 229–37. doi:10.1056/NEJMoa044383. PMID 16034008.
  2. London SJ, Connolly JL, Schnitt SJ, Colditz GA (1992). "A prospective study of benign breast disease and the risk of breast cancer". JAMA. 267 (7): 941–4. PMID 1734106.
  3. Dupont WD, Page DL (1985). "Risk factors for breast cancer in women with proliferative breast disease". N Engl J Med. 312 (3): 146–51. doi:10.1056/NEJM198501173120303. PMID 3965932.
  4. Love SM, Gelman RS, Silen W (1982). "Sounding board. Fibrocystic "disease" of the breast--a nondisease?". N Engl J Med. 307 (16): 1010–4. doi:10.1056/NEJM198210143071611. PMID 7110289.
  5. Dupont WD, Page DL (1985). "Risk factors for breast cancer in women with proliferative breast disease". N Engl J Med. 312 (3): 146–51. doi:10.1056/NEJM198501173120303. PMID 3965932.
  6. Page DL, Dupont WD, Rogers LW, Landenberger M (1982). "Intraductal carcinoma of the breast: follow-up after biopsy only". Cancer. 49 (4): 751–8. PMID 6275978.
  7. Lanyi, M (2003). Mammography : diagnosis and pathological analysis. Berlin New York: Springer-Verlag. ISBN 9783540441137.
  8. Lai EC, Chan WC, Ma TK, Tang AP, Poon CS, Leong HT (2005). "The role of conservative treatment in idiopathic granulomatous mastitis". Breast J. 11 (6): 454–6. doi:10.1111/j.1075-122X.2005.00127.x. PMID 16297091.
  9. Kudva YC, Reynolds C, O'Brien T, Powell C, Oberg AL, Crotty TB (2002). ""Diabetic mastopathy," or sclerosing lymphocytic lobulitis, is strongly associated with type 1 diabetes". Diabetes Care. 25 (1): 121–6. PMID 11772912.


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