B-cell lymphoma classification: Difference between revisions

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__NOTOC__
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{{B-cell lymphoma}}
{{B-cell lymphoma}}
{{CMG}}
{{CMG}} ; {{AE}} {{Adnan Ezici}}
==Overview==
==Overview==
B-cell lymphomas include both [[Hodgkin's lymphoma]]s and most [[Non-Hodgkin lymphomas]]. [[Hodgkin's lymphoma]] may be classified according to the [[World Health Organization|World Health Organisation]] classification system into 2 groups: nodular lymphocyte-predominant Hodgkin lymphoma and classical Hodgkin lymphoma (includes nodular sclerosis classical Hodgkin lymphoma, lymphocyte-rich classical Hodgkin lymphoma, mixed cellularity classical Hodgkin lymphoma, and lymphocyte-depleted classical Hodgkin lymphoma). [[Non-Hodgkin lymphomas]] may be classified into several subtypes based on the [[World Health Organization|World Health Organisation]] classification system.
==Classification==
==Classification==
B-cell lymphomas include both [[Hodgkin's lymphoma]]s and most [[Non-Hodgkin lymphomas]].
*[[Hodgkin's lymphoma]] may be classified according to the [[World Health Organization|World Health Organisation]] classification system into 2 groups:<ref name="pmid26980727">{{cite journal |vauthors=Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES |title=The 2016 revision of the World Health Organization classification of lymphoid neoplasms |journal=Blood |volume=127 |issue=20 |pages=2375–90 |date=May 2016 |pmid=26980727 |pmc=4874220 |doi=10.1182/blood-2016-01-643569 |url=}}</ref>
**Nodular lymphocyte predominant Hodgkin lymphoma
**Classical Hodgkin lymphoma (includes 4 subtypes)
***Nodular sclerosis classical Hodgkin lymphoma
***Lymphocyte-rich classical Hodgkin lymphoma
***Mixed cellularity classical Hodgkin lymphoma
***Lymphocyte-depleted classical Hodgkin lymphoma
*[[Non-Hodgkin lymphoma]] may be classified according to the [[World Health Organization|World Health Organisation]] classification system into 2 groups including B-cell neoplasms, and T-cell and putative NK-cell neoplasms. B-cell neoplasms may further be classified according to the [[World Health Organization|World Health Organisation]] into: <ref name="pmid26980727">{{cite journal |vauthors=Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES |title=The 2016 revision of the World Health Organization classification of lymphoid neoplasms |journal=Blood |volume=127 |issue=20 |pages=2375–90 |date=May 2016 |pmid=26980727 |pmc=4874220 |doi=10.1182/blood-2016-01-643569 |url=}}</ref><ref name="”cancer">National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/publications/pdq</ref><ref name="pmid27354024">{{cite journal |vauthors=Perry AM, Diebold J, Nathwani BN, MacLennan KA, Müller-Hermelink HK, Bast M, Boilesen E, Armitage JO, Weisenburger DD |title=Non-Hodgkin lymphoma in the developing world: review of 4539 cases from the International Non-Hodgkin Lymphoma Classification Project |journal=Haematologica |volume=101 |issue=10 |pages=1244–1250 |date=October 2016 |pmid=27354024 |pmc=5046654 |doi=10.3324/haematol.2016.148809 |url=}}</ref>
**[[Chronic lymphocytic leukemia|Chronic lymphocytic leukemia/small lymphocytic lymphoma]]
**[[Monoclonal B-cell lymphocytosis]]
**[[B-cell prolymphocytic leukemia]]
**[[Splenic marginal zone lymphoma]]
**[[Hairy cell leukemia]]
**Splenic B-cell lymphoma/leukemia, unclassifiable
***Splenic diffuse red pulp small B-cell lymphoma
***Hairy cell leukemia-variant
**[[Lymphoplasmacytic lymphoma]]
***[[Waldenström macroglobulinemia]]
**[[Monoclonal gammopathy of undetermined significance]] (MGUS), IgM
**μ heavy-chain disease
**ɣ heavy-chain disease
**a heavy-chain disease
**[[Monoclonal gammopathy of undetermined significance]] (MGUS), IgG/A
**[[Plasma cell myeloma]]
**Solitary plasmacytoma of bone
**Extraosseous plasmacytoma
**Monoclonal immunoglobulin deposition diseases
**[[MALT lymphoma|Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)]]
**[[Nodal marginal zone lymphoma]]
***Pediatric nodal marginal zone lymphoma
**[[Follicular lymphoma]]
***In situ follicular neoplasia
***Duodenal-type follicular lymphoma
**Pediatric-type follicular lymphoma
**Large B-cell lymphoma with IRF4 rearrangement
**Primary cutaneous follicle center lymphoma
**[[Mantle cell lymphoma]]
***In situ mantle cell neoplasia
**[[Diffuse large B cell lymphoma|Diffuse large B-cell lymphoma (DLBCL), not otherwise specified (NOS)]]
***Germinal center B-cell type
***Activated B-cell type
**T-cell/histiocyte-rich large B-cell lymphoma
**[[Diffuse large B cell lymphoma|Primary DLBCL of the central nervous system (CNS)]]
**[[Diffuse large B cell lymphoma|Primary cutaneous DLBCL, leg type]]
**[[Diffuse large B cell lymphoma|EBV (+) DLBCL, not otherwise specified (NOS)]]
**[[EBV]] (+) mucocutaneous ulcer
**DLBCL associated with chronic inflammation
**[[Lymphomatoid granulomatosis]]
**[[Primary mediastinal large B-cell lymphoma|Primary mediastinal (thymic) large B-cell lymphoma]]
**[[Intravascular large B-cell lymphoma]]
**ALK (+) large B-cell lymphoma
**Plasmablastic lymphoma
**[[Primary effusion lymphoma]]
**HHV8 (+) DLBCL, not otherwise specified (NOS)
**[[Burkitt lymphoma]]
**Burkitt-like lymphoma with 11q aberration
**High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 translocations
**High-grade B-cell lymphoma, not otherwise specified (HGBL, NOS)
**B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma
*[[Non-Hodgkin lymphoma]] may be classified according to rate of growth into 2 subtypes:
**Aggresive (high-grade)
**Indolent (low-grade)


There are numerous kinds of lymphomas involving B cells. The most commonly used classification system is the WHO classification, a convergence of more than one, older classification systems.  Five account for nearly three out of four patients with non-Hodgkin lymphoma:<ref name="The Lymphomas">{{cite web |url=http://www.leukemia-lymphoma.org/attachments/National/br_1161891669.pdf|title=The Lymphomas |accessdate=2008-04-07 |author= |authorlink= |coauthors= |date=May 2006 |format=PDF |publisher=The Leukemia & Lymphoma Society |pages=p. 12}}</ref>
===Most common===
 
Five account for nearly three out of four patients with non-Hodgkin lymphoma:<ref name="The Lymphomas">{{cite web |url=http://www.leukemia-lymphoma.org/attachments/National/br_1161891669.pdf|title=The Lymphomas |accessdate=2008-04-07 |author= |authorlink= |coauthors= |date=May 2006 |format=PDF |publisher=The Leukemia & Lymphoma Society |pages=p. 12}}</ref>
* [[Diffuse large B cell lymphoma]]
* [[Diffuse large B cell lymphoma]]
* [[Follicular lymphoma]]
* [[Follicular lymphoma]]
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* [[Mantle cell lymphoma]] (MCL)
* [[Mantle cell lymphoma]] (MCL)


The remaining nine are much less common:<ref name="The Lymphomas"/>
===Rare===
The remaining forms are much less common:<ref name="The Lymphomas"/>
* [[Burkitt lymphoma]]
* [[Burkitt lymphoma]]
* Mediastinal large B cell lymphoma
* Mediastinal large B cell lymphoma
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* B-cell lymphoma, unclassifiable with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma
* B-cell lymphoma, unclassifiable with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma
* B-cell lymphoma, unclassifiable with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma
* B-cell lymphoma, unclassifiable with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma
Additionally, some researchers separate out lymphomas that appear result from other immune system disorders, such as [[AIDS-related lymphoma]].


==References==
==References==
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[[Category:Types of cancer]]
[[Category:Types of cancer]]
[[Category:Hematology]]
[[Category:Hematology]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Hematology]]
[[Category:Immunology]]

Latest revision as of 19:14, 14 January 2022

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Adnan Ezici, M.D[2]

Overview

B-cell lymphomas include both Hodgkin's lymphomas and most Non-Hodgkin lymphomas. Hodgkin's lymphoma may be classified according to the World Health Organisation classification system into 2 groups: nodular lymphocyte-predominant Hodgkin lymphoma and classical Hodgkin lymphoma (includes nodular sclerosis classical Hodgkin lymphoma, lymphocyte-rich classical Hodgkin lymphoma, mixed cellularity classical Hodgkin lymphoma, and lymphocyte-depleted classical Hodgkin lymphoma). Non-Hodgkin lymphomas may be classified into several subtypes based on the World Health Organisation classification system.

Classification

B-cell lymphomas include both Hodgkin's lymphomas and most Non-Hodgkin lymphomas.

Most common

Five account for nearly three out of four patients with non-Hodgkin lymphoma:[4]

Rare

The remaining forms are much less common:[4]

References

  1. ↑ 1.0 1.1 Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES (May 2016). "The 2016 revision of the World Health Organization classification of lymphoid neoplasms". Blood. 127 (20): 2375–90. doi:10.1182/blood-2016-01-643569. PMC 4874220. PMID 26980727.
  2. ↑ National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/publications/pdq
  3. ↑ Perry AM, Diebold J, Nathwani BN, MacLennan KA, Müller-Hermelink HK, Bast M, Boilesen E, Armitage JO, Weisenburger DD (October 2016). "Non-Hodgkin lymphoma in the developing world: review of 4539 cases from the International Non-Hodgkin Lymphoma Classification Project". Haematologica. 101 (10): 1244–1250. doi:10.3324/haematol.2016.148809. PMC 5046654. PMID 27354024.
  4. ↑ 4.0 4.1 "The Lymphomas" (PDF). The Leukemia & Lymphoma Society. May 2006. pp. p. 12. Retrieved 2008-04-07.

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