Autoimmune hemolytic anemia classification

Autoimmune hemolytic anemia Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Autoimmune hemolytic anemia from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
X-ray
Echocardiography and Ultrasound
CT
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Autoimmune hemolytic anemia classification On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Autoimmune hemolytic anemia classification All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Autoimmune hemolytic anemia classification
CDC on Autoimmune hemolytic anemia classification
Autoimmune hemolytic anemia classification in the news
Blogs on Autoimmune hemolytic anemia classification
Directions to Hospitals Treating Autoimmune hemolytic anemia
Risk calculators and risk factors for Autoimmune hemolytic anemia classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Assosciate Editor(s)-In-Chief: Prashanth Saddala M.B.B.S; Shyam Patel [2]

Classification

Category	Features
Warm-antibody type	Due to IgG subtype Extravascular hemolysis
Cold-antibody type	Due to IgM subtype Intravascular hemolysis Recognition by the reticuloendothelial system Destruction by macrophages Associated with cold agglutinin disease Associated with paroxysmal cold hemoglobinuria Associated with Mycoplasma infection Associated with malignancy
Mixed warm-antibody and cold-antibody type	Due to IgM subtype Mixed features

Intravascular haemolysis
Red blood cell lysis occurs in the circulation as a result of activation of the complement system cascade.

Extravascular haemolysis
Red Blood Cells that are coated with antibodies are specifically recognised in the reticuloendothelial system and destroyed by macrophages.

Subtypes

• Warm antibody autoimmune hemolytic anemia

• Idiopathic
• Systemic lupus erythematosus
• Evans' syndrome (antiplatelet antibodies and haemolytic antibodies)
• Chronic lymphocytic leukemia
• Drugs (methyldopa)

• Cold antibody autoimmune hemolytic anemia

• Idiopathic cold hemagglutinin syndrome
• Infectious mononucleosis
• Paroxysmal cold hemoglobinuria (rare)
• Lymphoma

• Mixed-type autoimmune hemolytic anemia

References

Template:WikiDoc Sources