Atypical teratoid rhabdoid tumor epidemiology and demographics: Difference between revisions
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==Overview== | ==Overview== | ||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
In the United States, three children per 1,000,000 or around 30 new AT/RT cases are diagnosed each year. AT/RT represents around 3% of pediatric [[cancer]]s of the central nervous system (CNS).<ref>[http://www.epa.gov/envirohealth/children/child_illness/d6-graph.htm Measure D6: Types of Childhood Cancer] – 2006 Tables D6a & D6b. U.S. Environmental Protection Agency. Retrieved on [[2008-04-17]].</ref> | |||
Around 17% of all pediatric cancers involve the CNS; it is the most common childhood solid tumor. The survival rate for CNS tumors is around 60%; with AT/RT it is around 10%. Pediatric brain cancer is the second leading cause of childhood death, just after [[leukemia]]. Recent trends suggest that the rate of overall CNS tumor diagnosis is increasing by about 2.7% per year. As diagnostic techniques using genetic markers improve and are used more often, the proportion of AT/RT diagnoses is expected to increase. | |||
Since it is highly [[cancer|malignant]], AT/RT has a high [[mortality rate]]. A survey of 36 AT/RT patients at St. Jude Children's Hospital from 1984 to 2003 showed the survival rate for children under three is less than 10%, whereas for older children, the survival rate is potentially over 70%.<ref>{{cite journal |author=Tekautz TM, Fuller CE, Blaney S, ''et al'' |title=Atypical teratoid/rhabdoid tumors (ATRT): improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapy |journal=[[J. Clin. Oncol.]] |volume=23 |issue=7 |pages=1491–9 |year=2005 |pmid=15735125 |doi=10.1200/JCO.2005.05.187 |url=http://jco.ascopubs.org/cgi/content/full/23/7/1491}} See Figure 1.</ref> Because most patients with AT/RT are less than three years old, the overall prognosis for AT/RT is very poor. | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Epidemiology and Demographics
In the United States, three children per 1,000,000 or around 30 new AT/RT cases are diagnosed each year. AT/RT represents around 3% of pediatric cancers of the central nervous system (CNS).[1] Around 17% of all pediatric cancers involve the CNS; it is the most common childhood solid tumor. The survival rate for CNS tumors is around 60%; with AT/RT it is around 10%. Pediatric brain cancer is the second leading cause of childhood death, just after leukemia. Recent trends suggest that the rate of overall CNS tumor diagnosis is increasing by about 2.7% per year. As diagnostic techniques using genetic markers improve and are used more often, the proportion of AT/RT diagnoses is expected to increase.
Since it is highly malignant, AT/RT has a high mortality rate. A survey of 36 AT/RT patients at St. Jude Children's Hospital from 1984 to 2003 showed the survival rate for children under three is less than 10%, whereas for older children, the survival rate is potentially over 70%.[2] Because most patients with AT/RT are less than three years old, the overall prognosis for AT/RT is very poor.
References
- ↑ Measure D6: Types of Childhood Cancer – 2006 Tables D6a & D6b. U.S. Environmental Protection Agency. Retrieved on 2008-04-17.
- ↑ Tekautz TM, Fuller CE, Blaney S; et al. (2005). "Atypical teratoid/rhabdoid tumors (ATRT): improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapy". J. Clin. Oncol. 23 (7): 1491–9. doi:10.1200/JCO.2005.05.187. PMID 15735125. See Figure 1.