Atypical teratoid rhabdoid tumor differential diagnosis: Difference between revisions

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==Differentiating Atypical Teratoid Rhabdoid Tumor from other Diseases==
==Differentiating Atypical Teratoid Rhabdoid Tumor from other Diseases==
 
Atypical teratoid rhabdoid tumor must be differentiated from:<ref name=ddxatrt1>Differential diagnosis of Atypical teratoid/rhabdoid tumour. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/atypical-teratoidrhabdoid-tumour. Accessed on December 14, 2015</ref>
The critical step in treatment planning is to determine the correct histology of the tumor.  Misidentification of the tumor histology can lead to errors in treatment and prognosis.<ref> {{cite journal
*[[Medulloblastoma]]
|author=Jay V, Edwards V, Halliday W, Rutka J, Lau R
*[[Pineoblastoma]]
|title="Polyphenotypic" tumors in the central nervous system: problems in nosology and classification
*Spinal PNET
|journal=Pediatr Pathol Lab Med
|volume=17
|issue=3
|pages=369–89
|year=1997
|pmid=9185218
|doi=
|url=
}}</ref> 
 
Atypical teratoid/rhaboid tumor closely resembles medulloblastoma,<ref>
{{cite journal |author=Burger PC, Yu IT, Tihan T, ''et al'' |title=Atypical teratoid/rhabdoid tumor of the central nervous system: a highly malignant tumor of infancy and childhood frequently mistaken for medulloblastoma: a Pediatric Oncology Group study |journal=Am. J. Surg. Pathol. |volume=22 |issue=9 |pages=1083–92 |year=1998 |pmid=9737241 |doi=}}
</ref> [[primitive neuroectodermal tumor]], [[choroid plexus]] [[carcinoma]], and some kinds of [[germ cell tumor]].<!-- which kinds of germ cell tumor? -->  Because rhabdoid characteristics<!-- defined above? --> are not the only component of AT/RT, some sections of an AT/RT may resemble other tumors.  These characteristics may be present only in focal areas or may be less pronounced.
 
It is important to consider AT/RT when a medulloblastoma or PNET is suspected, particularly in a child under the age of one.  [[Cytogenetics|Cytogenetic]] studies can assist in differentiating MB/PNETs from AT/RTs.  Some kinds of [[germ cell tumor]] secrete [[tumor marker]]s [[Alpha-fetoprotein|AFP]] or [[bHCG]]; AT/RTs do not.


==References==
==References==

Revision as of 20:26, 14 December 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

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Differentiating Atypical Teratoid Rhabdoid Tumor from other Diseases

Atypical teratoid rhabdoid tumor must be differentiated from:[1]

References

  1. ↑ Differential diagnosis of Atypical teratoid/rhabdoid tumour. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/atypical-teratoidrhabdoid-tumour. Accessed on December 14, 2015

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