Ascending cholangitis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anila Hussain, MD [2]

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Overview

Any condition that leads to stasis or obstruction of bile in the common bile duct can lead to bacterial infection and cholangitis. Most common causes include bile duct stones and benign or malignant strictures. Less common causes include parasitic infection, malignancy, or extrinsic compression by the pancreas. Partial obstruction has a higher rate of infection as compared to complete obstruction

Causes

Ascending Cholangitis results from a bacterial infection that is usually due to the bile stasis following a chronic obstruction. Some of the causes leading to ascending cholangitis are mentioned below[1].[2]

Common causes[3]

Less common causes

Microbiology

The infecting organisms are usually gram-negative bacilli (eg, E. coli, Klebsiella, Pseudomonas, Bacteroides and Enterococcus)[5]

References

  1. Kimura Y, Takada T, Kawarada Y, Nimura Y, Hirata K, Sekimoto M; et al. (2007). "Definitions, pathophysiology, and epidemiology of acute cholangitis and cholecystitis: Tokyo Guidelines". J Hepatobiliary Pancreat Surg. 14 (1): 15–26. doi:10.1007/s00534-006-1152-y. PMC 2784509. PMID 17252293.
  2. Mosler P (2011). "Management of acute cholangitis". Gastroenterol Hepatol (N Y). 7 (2): 121–3. PMC 3061017. PMID 21475420.
  3. Gigot JF, Leese T, Dereme T, Coutinho J, Castaing D, Bismuth H (1989). "Acute cholangitis. Multivariate analysis of risk factors". Ann Surg. 209 (4): 435–8. PMC 1493983. PMID 2930289.
  4. Serradilla Martin, M.; Palomares Cano, A.; Dabán Collado, E.; Medina Cuadros, M. (2016). "Acute cholangitis secondary to main bile duct thrombi for hepatocellular carcinoma". HPB. 18: e745–e746. doi:10.1016/j.hpb.2016.01.225. ISSN 1365-182X.
  5. Lipsett PA, Pitt HA (1990). "Acute cholangitis". Surg Clin North Am. 70 (6): 1297–312. PMID 2247816.


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