Arterial and venous thrombosis differences and similarities: Difference between revisions
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Revision as of 23:55, 19 February 2012
| Arterial and venous thrombosis differences and similarities | |
| ICD-10 | I80-I82 |
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| ICD-9 | 437.6, 453, 671.5, 671.9 |
| MeSH | D013927 |
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Thrombosis Microchapters |
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Site of Thrombosis |
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Differentiating Thrombosis from other Diseases |
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Diagnosis |
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Treatment |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editors-in-Chief: Ujjwal Rastogi, MBBS [2]
Overview
More than a century ago, Virchow postulated that a triad of conditions (later called Virchow's triad) leads to Thrombus formation. Venous thrombosis has been associated with red blood cell and fibrin rich red clot while Arterial thrombosis occur on atherosclerotic lesions with active inflammation, and are rich in platelets and give an appearance of white clot [1]. Furthermore certain studies have indicated the role of platelet in Venous thrombosis[2]. Thus, traditionally, Venous thrombosis and Arterial thrombosis has been described as distinct diseases with different risk factors, pathology and treatment. However, recent studies have shown an association between them.
Similarities
The two vascular complications, venous and arterial thrombosis, share many risk factors such as:
- Obesity
- Hypertension
- Tobacco use.
- Dyslipidemia
- Diabetes mellitus
- Metabolic syndrome.
- Diet
- Age
- Hormonal replacement/Contraceptive therapy.
Furthermore there are many diseases that causes both arterial and venous thrombosis, such as:
- Antiphospholipid antibody syndrome,
- Hyperhomocysteinemia,
- Malignancies,
- Infections,
- Nephrotic Syndrome [3].
- Hormonal treatment,
- Bechet's disease,
- Poplitial artery aneurysm (Large aneurysm can compress the poplitial vein and cause DVT).
Differences
Arterial thrombosis occur at places of arterial plaque rupture where the shear rate is higher, in contrast Vein thrombosis occur at places where the vein wall is normal and blood flow and shear rate is low.
| Parameter | Arterial | Venous |
|---|---|---|
| Location | Arterial plaque rupture | Normal vein wall |
| Duration | takes decades to happen | occur rapidly |
| Shear rate | high | low |
| Role of Platelet | Excess platelet activation, thus called White clot | Less platelet activation, thus termed Red clot |
| Complication | More chances of distal thrombosis | Can cause Pulmonary embolism |
References
- ↑ Jerjes-Sanchez C (2005). "Venous and arterial thrombosis: a continuous spectrum of the same disease?". Eur Heart J. 26 (1): 3–4. doi:10.1093/eurheartj/ehi041. PMID 15615791.
- ↑ Sobieszczyk P, Fishbein MC, Goldhaber SZ (2002). "Acute pulmonary embolism: don't ignore the platelet". Circulation. 106 (14): 1748–9. PMID 12356622.
- ↑ Mahmoodi BK, ten Kate MK, Waanders F, Veeger NJ, Brouwer JL, Vogt L; et al. (2008). "High absolute risks and predictors of venous and arterial thromboembolic events in patients with nephrotic syndrome: results from a large retrospective cohort study". Circulation. 117 (2): 224–30. doi:10.1161/CIRCULATIONAHA.107.716951. PMID 18158362.