Antimycin A
WikiDoc Resources for Antimycin A |
Articles |
---|
Most recent articles on Antimycin A Most cited articles on Antimycin A |
Media |
Powerpoint slides on Antimycin A |
Evidence Based Medicine |
Clinical Trials |
Ongoing Trials on Antimycin A at Clinical Trials.gov Clinical Trials on Antimycin A at Google
|
Guidelines / Policies / Govt |
US National Guidelines Clearinghouse on Antimycin A
|
Books |
News |
Commentary |
Definitions |
Patient Resources / Community |
Patient resources on Antimycin A Discussion groups on Antimycin A Patient Handouts on Antimycin A Directions to Hospitals Treating Antimycin A Risk calculators and risk factors for Antimycin A
|
Healthcare Provider Resources |
Causes & Risk Factors for Antimycin A |
Continuing Medical Education (CME) |
International |
|
Business |
Experimental / Informatics |
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Antimycin A is a chemical compound produced by streptomyces bacteria.
Uses
It is the active ingredient in Fintrol(R), a chemical piscicide (fish poison) used in fisheries management and in the catfish industry.
It is also used as an antibiotic.
Mechanism
Antimycin A functions by inhibiting the oxidation of ubiquinol in the electron transport chain, ultimately preventing the formation of ATP.
More specifically, Antimycin A binds to the Qi site of Complex III (the enzyme cytochrome c oxidoreductase), in the cytochrome b subunit.
The inhibition of Complex III by Antimycin A result in the formation of large quantities of the toxic free radical, Superoxide.
It has also been found to inhibit the cyclic electron flow within photosynthetic systems along the proposed ferredoxin quinone reductase pathway.
Antimycin blocks the flow of electrons from semiquinone to ubiquinone in the Q-cycle of complex III in oxidative phosphorylation. By doing so it inhibits the electron transport pathway thus preventing the consumption of oxygen (which occurs at Complex IV) and disrupting the proton gradient across the inner membrane. It is the disruption of the proton gradient that prevents the production of ATP as protons are unable to flow through the ATP synthase complex.