Amyotrophic lateral sclerosis epidemiology and demographics: Difference between revisions

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*ALS is one of the most common neuromuscular diseases worldwide, and people of all races and ethnic backgrounds are affected.
*ALS is one of the most common neuromuscular diseases worldwide, and people of all races and ethnic backgrounds are affected.
*Between 1 to 2 people per 100,000 develop ALS each year . ALS most commonly strikes people between 40 and 60 years of age, but younger and older people can also develop the disease. Men are affected slightly more often than women.
*Between 1 to 2 people per 100,000 develop ALS each year . ALS most commonly strikes people between 40 and 60 years of age, but younger and older people can also develop the disease. Men are affected slightly more often than women.
*Although there have been reports of several "clusters" including three American football players from the San Francisco 49ers, three soccer-playing friends in the south of England, and reports of conjugal (''i.e.'', husband and wife) cases in the south of France<ref name="ALS1">{{cite journal | author = Rachele MG, Mascia V, Tacconi P, Dessi N, Marrosu F | title = Conjugal amyotrophic lateral sclerosis: a report on a couple from Sardinia, Italy.  | journal = Ital J Neurol Sci. | volume = Apr;19 | issue = 2 | pages = 97-100 | year = 1998 | id =  PMID: 10935845}}</ref><ref name="ALS2">{{cite journal | author = Poloni M, Micheli A, Facchetti D, Mai R, Ceriani F | title = Conjugal amyotrophic lateral sclerosis: toxic clustering or change?| journal = Ital J Neurol Sci. | volume = Apr;18 | issue = 2 | pages = 109-12 | year = 1997 | id = PMID: 9239532}}</ref><ref name="ALS3">{{cite journal | author = Camu W, Cadilhac J, Billiard M.  | title = Conjugal amyotrophic lateral sclerosis: a report on two couples from southern France.| journal =  Neurology.  | volume = Mar;44 | issue = 3 Pt 1 | pages = 547-8  | year = 1994 | id = PMID: 8145930}}</ref><ref name="ALS4">{{cite journal | author = Cornblath DR, Kurland LT, Boylan KB, Morrison L, Radhakrishnan K, Montgomery M. | title = Conjugal amyotrophic lateral sclerosis: report of a young married couple.| journal =  Neurology.| volume =  Nov;43 | issue = 11 | pages =  2378-80 | year = 1993 | id = PMID: 8232960}}</ref> <ref name="9couples">{{cite journal | author = Corcia P, Jafari-Schluep HF, Lardillier D, Mazyad H, Giraud P, Clavelou P, Pouget J, Camu W | title = A clustering of conjugal amyotrophic lateral sclerosis in southeastern France. | journal = Neurol. | volume = Apr;60 | issue = 4 | pages = 553-7 | year = 2003 | id = PMID: 12707069}}</ref>, these are statistically plausible chance events. Although many authors consider ALS to be caused by a combination of genetic and environmental risk factors, so far the latter have not been firmly identified, other than a higher risk with increasing age.
*Although there have been reports of several "clusters" including three American football players from the San Francisco 49ers, three soccer-playing friends in the south of England, and reports of conjugal (''i.e.'', husband and wife) cases in the south of France<ref name="ALS1">{{cite journal | author = Rachele MG, Mascia V, Tacconi P, Dessi N, Marrosu F | title = Conjugal amyotrophic lateral sclerosis: a report on a couple from Sardinia, Italy.  | journal = Ital J Neurol Sci. | volume = Apr;19 | issue = 2 | pages = 97-100 | year = 1998 | id =  PMID: 10935845}}</ref><ref name="ALS2">{{cite journal | author = Poloni M, Micheli A, Facchetti D, Mai R, Ceriani F | title = Conjugal amyotrophic lateral sclerosis: toxic clustering or change?| journal = Ital J Neurol Sci. | volume = Apr;18 | issue = 2 | pages = 109-12 | year = 1997 | id = PMID: 9239532}}</ref><ref name="ALS3">{{cite journal | author = Camu W, Cadilhac J, Billiard M.  | title = Conjugal amyotrophic lateral sclerosis: a report on two couples from southern France.| journal =  Neurology.  | volume = Mar;44 | issue = 3 Pt 1 | pages = 547-8  | year = 1994 | id = PMID: 8145930}}</ref><ref name="ALS4">{{cite journal | author = Cornblath DR, Kurland LT, Boylan KB, Morrison L, Radhakrishnan K, Montgomery M. | title = Conjugal amyotrophic lateral sclerosis: report of a young married couple.| journal =  Neurology.| volume =  Nov;43 | issue = 11 | pages =  2378-80 | year = 1993 | id = PMID: 8232960}}</ref><ref name="9couples">{{cite journal | author = Corcia P, Jafari-Schluep HF, Lardillier D, Mazyad H, Giraud P, Clavelou P, Pouget J, Camu W | title = A clustering of conjugal amyotrophic lateral sclerosis in southeastern France. | journal = Neurol. | volume = Apr;60 | issue = 4 | pages = 553-7 | year = 2003 | id = PMID: 12707069}}</ref>, these are statistically plausible chance events. Although many authors consider ALS to be caused by a combination of genetic and environmental risk factors, so far the latter have not been firmly identified, other than a higher risk with increasing age.


==References==
==References==

Revision as of 12:52, 24 August 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Epidemiology and Demographics

  • ALS is one of the most common neuromuscular diseases worldwide, and people of all races and ethnic backgrounds are affected.
  • Between 1 to 2 people per 100,000 develop ALS each year . ALS most commonly strikes people between 40 and 60 years of age, but younger and older people can also develop the disease. Men are affected slightly more often than women.
  • Although there have been reports of several "clusters" including three American football players from the San Francisco 49ers, three soccer-playing friends in the south of England, and reports of conjugal (i.e., husband and wife) cases in the south of France[1][2][3][4][5], these are statistically plausible chance events. Although many authors consider ALS to be caused by a combination of genetic and environmental risk factors, so far the latter have not been firmly identified, other than a higher risk with increasing age.

References

  1. Rachele MG, Mascia V, Tacconi P, Dessi N, Marrosu F (1998). "Conjugal amyotrophic lateral sclerosis: a report on a couple from Sardinia, Italy". Ital J Neurol Sci. Apr;19 (2): 97–100. PMID: 10935845.
  2. Poloni M, Micheli A, Facchetti D, Mai R, Ceriani F (1997). "Conjugal amyotrophic lateral sclerosis: toxic clustering or change?". Ital J Neurol Sci. Apr;18 (2): 109–12. PMID: 9239532.
  3. Camu W, Cadilhac J, Billiard M. (1994). "Conjugal amyotrophic lateral sclerosis: a report on two couples from southern France". Neurology. Mar;44 (3 Pt 1): 547–8. PMID: 8145930.
  4. Cornblath DR, Kurland LT, Boylan KB, Morrison L, Radhakrishnan K, Montgomery M. (1993). "Conjugal amyotrophic lateral sclerosis: report of a young married couple". Neurology. Nov;43 (11): 2378–80. PMID: 8232960.
  5. Corcia P, Jafari-Schluep HF, Lardillier D, Mazyad H, Giraud P, Clavelou P, Pouget J, Camu W (2003). "A clustering of conjugal amyotrophic lateral sclerosis in southeastern France". Neurol. Apr;60 (4): 553–7. PMID: 12707069.

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