Allergy differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Marufa Marium, M.B.B.S[2]

Overview

Allergy must be differentiated from other diseases that cause Dermatological (Urticaria, pruritus, flushing, Angioedema), Respiratory (Rhinorrhea,chest tightness,Wheezing, Dyspnoea, Sneezing, Shortness of breath) Mucosal (Mucosal swelling affecting nose, lips, tongue, larynx, pharynx, conjunctiva, GIT) Ocular (Periorbital edema, Conjunctival Congesion, Itching), Systemic (Hypotension). Allergy can be differentiated according to the type of allergy.

Differentiating [[allergy] from other Diseases

Allergy must be differentiated from other diseases that cause Dermatological (Urticaria, pruritus, flushing, Angioedema), Respiratory (Rhinorrhea,chest tightness,Wheezing, Dyspnoea, Sneezing, Shortness of breath) Mucosal (Mucosal swelling affecting nose, lips, tongue, larynx, pharynx, conjunctiva, GIT) Ocular (Periorbital edema, Conjunctival Congesion, Itching), Systemic (Hypotension). Allergy can be differentiated according to the types of allergy.

Differentiating Allergy from other diseases on the basis of Dermatological, Respiratory, Mucosal, Ocular, Systemic Manifestations

On the basis Dermatological, Respiratory, Mucosal, Ocular, Systemic Manifestations, Allergy must be differentiated according to the types of allergy.

• Food Allergy is differentiated from enzyme deficiencies like lactose intolerance, fructose intolerance, Celiac Disease, Toxic reactions, Irritable bowel syndrome, Tyramine or caffeine toxicity, Gustatory Rhinitis.

Diseases	Clinical manifestations						Para-clinical findings							Gold standard	Additional findings
	Symptoms																		Physical examination
				Lab Findings			Imaging						Histopathology
	Abdominal Pain	Diarrhea	Dysphagia	Bloating/Flatulence	Regurgitation/Reflux	Urticaria/Oral Ulcer	Dyspnea	Pruritus/Flushing	Gastrointestinal	Dermatological	Respiratory	Mucosal				Ocular	Systemic and Other	Complete metabolic panel	IgA or IgG anti TTG, HLA-DQ2/DQ8	Hydrogen/Fructose breath Test, lactose intolerance test	Hydrogen/Fructose breath Test, lactose intolerance test	Stool acidity test	Endoscopy	Colonoscopy and Sigmoidoscopy	Barium Enema and X-ray	CT	MRI
Enzyme deficiencies
Inflammatory Bowel Disease
Celiac Disease
Toxic reactions
Diseases	Symptom 1	Symptom 2	Symptom 3	Physical exam 1	Physical exam 2	Physical exam 3	Lab 1	Lab 2	Lab 3	Imaging 1	Imaging 2	Imaging 3	Histopathology	Gold standard	Additional findings
Irritable bowel syndrome
Tyramine or caffeine toxicity
Gustatory Rhinitis

References

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]