Adult-onset Still's disease diagnostic study of choice

Template:Adult-onset Still's disease

Diagnostic study of choice/ Diagnostic criteria

The diagnosis of adult-onset Still's disease is made clinically along with supporting laboratory abnormalities and exclusion of other rheumatologic disorders, malignancy and infections. Three diagnostic criteria have been established in order to aid in the diagnosis of AOSD. Yamaguchi criteria is widely adopted. The following table outlines the major criteria system for the diagnosis of AOSD:

Criteria	Yamaguchi criteria	Cush criteria	Fautrel criteria
Major criteria	Arthralgia >2 weeks	Daily fever >39°	Spiking fever ⩾39°
	Fever >39°, intermittent, high spiking, ⩾1 week	Still's (maculopapular) rash	Arthralgia
	Maculopapular rash on trunks and/or extremities	WBCs >12000/ml +ESR >40 mm/1st hour	Transient erythema
	Leukocytosis- WBCs >10000 (>80% neutrophils)	Νegative RF and ANA	Pharyngitis
		Carpal ankylosis	Polymorphonuclear cells ⩾80%
			Glycosylated ferritin ⩽20%
Minor criteria
	Sore throat	Onset age <35 years	Maculopapular rash
	Lymphadenopathy	Arthritis	Leucocytes ⩾10×109/l
	Abnormal liver function tests (LDH, ALT, AST)	Prodromal sore throat
	Negative ANA and RF	Reticuloendothelial involvement or abnormal LFTs
	Hepatosplenomegaly	Serositis