AP2S1

Adaptor-related protein complex 2, sigma 1 subunit
PDB rendering based on 1gw5.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1gw5​
Identifiers
Symbols	AP2S1 ; AP17; AP17-DELTA; CLAPS2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3001
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Adaptor-related protein complex 2, sigma 1 subunit, also known as AP2S1, is a human gene.

One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts.

Further reading

• Pearse BM, Smith CJ, Owen DJ (2000). "Clathrin coat construction in endocytosis". Curr. Opin. Struct. Biol. 10 (2): 220–8. PMID 10753805.CS1 maint: Multiple names: authors list (link)
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Byland R, Vance PJ, Hoxie JA, Marsh M (2007). "A conserved dileucine motif mediates clathrin and AP-2-dependent endocytosis of the HIV-1 envelope protein". Mol. Biol. Cell. 18 (2): 414–25. doi:10.1091/mbc.E06-06-0535. PMID 17108326.CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Batonick M, Favre M, Boge M; et al. (2006). "Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2". Virology. 342 (2): 190–200. doi:10.1016/j.virol.2005.08.001. PMID 16139856.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vendeville A, Rayne F, Bonhoure A; et al. (2005). "HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses". Mol. Biol. Cell. 15 (5): 2347–60. doi:10.1091/mbc.E03-12-0921. PMID 15020715.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Collins BM, McCoy AJ, Kent HM; et al. (2002). "Molecular architecture and functional model of the endocytic AP2 complex". Cell. 109 (4): 523–35. PMID 12086608.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Berlioz-Torrent C, Shacklett BL, Erdtmann L; et al. (1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins". J. Virol. 73 (2): 1350–61. PMID 9882340.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holzmann K, Pöltl A, Sauermann G (1998). "A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17". Gene. 220 (1–2): 39–44. PMID 9767099.CS1 maint: Multiple names: authors list (link)
• Winterpacht A, Endele S, Enklaar T; et al. (1997). "Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2-->q13.3". Cytogenet. Cell Genet. 75 (2–3): 132–5. PMID 9040778.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Page LJ, Robinson MS (1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". J. Cell Biol. 131 (3): 619–30. PMID 7593184.
• Kirchhausen T, Nathanson KL, Matsui W; et al. (1989). "Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2". Proc. Natl. Acad. Sci. U.S.A. 86 (8): 2612–6. PMID 2495531.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kirchhausen T, Davis AC, Frucht S; et al. (1991). "AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast". J. Biol. Chem. 266 (17): 11153–7. PMID 2040623.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)