17-Hydroxyprogesterone: Difference between revisions

Jump to navigation Jump to search
No edit summary
No edit summary
Line 1: Line 1:
{{drugbox |
{{drugbox |
| IUPAC_name        = 17-Hidroxiprogesterona3D.png
| IUPAC_name        =17-Hidroxiprogesterona3D.png  
| image            =17-Hydroxyprogesterone.png
| image            =17-Hydroxyprogesterone.png
| CAS_number        =  
| CAS_number        =  

Revision as of 13:50, 15 April 2015

17-Hydroxyprogesterone
Pharmacokinetic data
MetabolismLiver
Identifiers
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC21H30O3
Molar mass330.22
Melting point219−220 °C (−145 °F)

WikiDoc Resources for 17-Hydroxyprogesterone

Articles

Most recent articles on 17-Hydroxyprogesterone

Most cited articles on 17-Hydroxyprogesterone

Review articles on 17-Hydroxyprogesterone

Articles on 17-Hydroxyprogesterone in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on 17-Hydroxyprogesterone

Images of 17-Hydroxyprogesterone

Photos of 17-Hydroxyprogesterone

Podcasts & MP3s on 17-Hydroxyprogesterone

Videos on 17-Hydroxyprogesterone

Evidence Based Medicine

Cochrane Collaboration on 17-Hydroxyprogesterone

Bandolier on 17-Hydroxyprogesterone

TRIP on 17-Hydroxyprogesterone

Clinical Trials

Ongoing Trials on 17-Hydroxyprogesterone at Clinical Trials.gov

Trial results on 17-Hydroxyprogesterone

Clinical Trials on 17-Hydroxyprogesterone at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on 17-Hydroxyprogesterone

NICE Guidance on 17-Hydroxyprogesterone

NHS PRODIGY Guidance

FDA on 17-Hydroxyprogesterone

CDC on 17-Hydroxyprogesterone

Books

Books on 17-Hydroxyprogesterone

News

17-Hydroxyprogesterone in the news

Be alerted to news on 17-Hydroxyprogesterone

News trends on 17-Hydroxyprogesterone

Commentary

Blogs on 17-Hydroxyprogesterone

Definitions

Definitions of 17-Hydroxyprogesterone

Patient Resources / Community

Patient resources on 17-Hydroxyprogesterone

Discussion groups on 17-Hydroxyprogesterone

Patient Handouts on 17-Hydroxyprogesterone

Directions to Hospitals Treating 17-Hydroxyprogesterone

Risk calculators and risk factors for 17-Hydroxyprogesterone

Healthcare Provider Resources

Symptoms of 17-Hydroxyprogesterone

Causes & Risk Factors for 17-Hydroxyprogesterone

Diagnostic studies for 17-Hydroxyprogesterone

Treatment of 17-Hydroxyprogesterone

Continuing Medical Education (CME)

CME Programs on 17-Hydroxyprogesterone

International

17-Hydroxyprogesterone en Espanol

17-Hydroxyprogesterone en Francais

Business

17-Hydroxyprogesterone in the Marketplace

Patents on 17-Hydroxyprogesterone

Experimental / Informatics

List of terms related to 17-Hydroxyprogesterone

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

17-Hydroxyprogesterone (17-OH progesterone or 17OHP) is a C-21 steroid hormone produced in the synthesis of glucocorticoids and sex steroids.

As a hormone, 17OHP also interacts with the progesterone receptor.

Production

It is derived from progesterone via 17-hydroxylase, a P450c17 enzyme, or from 17-hydroxypregnenolone via 3β-hydroxysteroid dehydrogenase/Δ5-4 isomerase.

17-Hydroxyprogesterone is a natural progestin and in pregnancy increases in the third trimester primarily due to fetal adrenal production.

This hormone is primarily produced in the adrenal glands and to some degree in the gonads, specifically the corpus luteum of the ovary. Normal levels are 3-90 ng/dl in children, and in women, 15-70 ng/dl prior to ovulation, and 35-290 ng/dl during the luteal phase.

17-hydroxyprogesterone caproate

17-Hydroxyprogesterone is not the same compound as 17-hydroxyprogesterone caproate. 17-Hydroxyprogesterone caproate is a synthetic (artificial) hormone that is similar in structure to medroxyprogesterone acetate and megestrol acetate.

The terminology is confusing because 17P is used both to refer to the natural hormone and the artificial/synthetic hormone. It is preferable to refer to the synthetic hormone as 17-OHPC.

Clinical use

Measurements of levels of 17-hydroxyprogesterone are useful in the evaluation of patients with suspected congenital adrenal hyperplasia as the typical enzymes that are defective, namely 21-hydroxylase and 11β-hydroxylase, lead to a build-up of 17OHP. In contrast, the rare patient with 17α-hydroxylase deficiency will have very low or undetectable levels of 17OHP. 17OHP levels can also be used to measure contribution of progestational activity of the corpus luteum during pregnancy as progesterone but not 17OHP is also contributed by the placenta.

The application of 17OHP has been shown to be useful to delay premature labor in pregnancy.[1][2]

17-Hydroxyprogesterone (17-OH-Prog in the diagram) may arise from either of two steroid precursors.

The use of 17-hydroxyprogesterone caproate in pregnancy to prevent preterm birth is not recommended without further study according to two authorities. A 2006 Cochrane Review concluded "...important maternal and infant outcomes have been poorly reported to date... information regarding the potential harms of progesterone therapy to prevent preterm birth is limited".[3] There was a similar conclusion from a review by Marc Keirse.[4] Three clinical studies of 250 mg/week of i.m. 17-hydroxyprogesterone caproate have all shown a trend for an increase in pregnancy loss due to miscarriage compared to placebo.[5][1][2][6] There has also been a study in rhesus monkeys in which all rhesus fetuses exposed to 1 and 10 times the human dose equivalent of 17-hydroxyprogesterone caproate died in utero.[7] Currently, 17-hydroxyprogesterone caproate is a category D progestin according to the FDA (evidence of fetal harm). There is speculation that the castor oil in the 17-hydroxyprogesterone caproate formulation may not be beneficial for pregnancy.[8][9]

Additional images

References

  1. 1.0 1.1 Yemini M, Borenstein R, Dreazen, et al. Prevention of premature labor by 17 alpha-hydroxyprogesterone caproate. Am J Obstet Gynecol. 1985;151(5):574-7.PMID 3976757.
  2. 2.0 2.1 Meis PJ; Society for Maternal-Fetal Medicine. 17 hydroxyprogesterone for the prevention of preterm delivery. Obstet Gynecol. 2005;105:1128-35.PMID 15863556.
  3. Dodd JM, Flenady V, Cincotta R, Crowther CA; The Cochrane Database of Systematic Reviews 2006 Issue 1
  4. Keirse MJNC. Progesterone and Preterm: Seventy Years of "Deja vu" or "Still To Be Seen"?. Birth, 2004 September; 31:3.
  5. Johnson JWC, Austin KL, Jones GS, Davis GH, King TM. Efficacy of 17 alpha-hydroxyprogesterone caproate in the prevention of premature labor. NEJM 1975 October. 293(14):675.
  6. Keirse MJNC, Progestogen administration in pregnancy may prevent preterm delivery. Br J Obstet Gynecol 1990 February; 97:149.
  7. Hendrix AG, et al. Embriotoxicity of sex steroidal hormones in nonhuman primates: II. Hydroxyprogesterone caproate, estradiol valerate. Teratology 1987 February. 35 (1): 129.
  8. Duke University Medical Center, New England Journal of Medicine, correspondence, vol 349.
  9. Hauth JC, Gilstrap LC, Brekken AL, Hauth JM. The effect of 17 alpha-hydroxyprogesterone caproate on pregnancy outcome in an active-duty military population. Am J Obstet Gynecol. 1983 May; 146(2): 187.

External links


Template:WikiDoc Sources