Astrocytoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

There are two broad classes of classification identified within astrocytomas, based on histology, as to whether the zones of infiltration of cancer cells are narrow or diffuse.

Classification

Within the astrocytomas, there are two broad classes recognized in literature, those with:

  • Narrow zones of infiltration (mostly invasive tumors; e.g., pilocytic astrocytoma, subependymal giant cell astrocytoma, pleomorphic xanthoastrocytoma), that often are clearly outlined on diagnostic images
  • Diffuse zones of infiltration (e.g., low-grade astrocytoma, anaplastic astrocytoma, glioblastoma), that share various features, including the ability to arise at any location in the CNS, but with a preference for the cerebral hemispheres; they occur usually in adults; and an intrinsic tendency to progress to more advanced grades.[1]

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