Acetyldihydrocodeine

Acetyldihydrocodeine

File:Acetyldihydrocodeine.svg
Clinical data
Synonyms	Acetyldihydrocodeine, Dihydrothebacone, 6-acetyl-7,8-dihydrocodeine
ATC code	R05DA12 (WHO)
Identifiers
IUPAC name 3-methoxy-6-acetoxy-(5α,6α)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan
CAS Number	3861-72-1
PubChem CID	5463874
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C20H25NO4
Molar mass	343.417 g/mol

Acetyldihydrocodeine is an opiate derivative developed as a cough suppressant and analgesic. It is not commonly used, but has activity similar to other opiates. Acetyldihydrocodeine can be described as the 6-acetyl derivative of dihydrocodeine and is metabolised in the liver by demethylation and deacetylation to produce dihydromorphine.

Since acetyldihydrocodeine has higher lipophilicity than codeine and is converted into dihydromorphine rather than morphine, it can be expected to be more potent and longer lasting, and also have higher bioavailability than codeine. Side effects are similar to those of other opiates and include itching, nausea and respiratory depression.