Patent foramen ovale and migraine
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Priyamvada Singh, M.B.B.S. [2]; Assistant Editor-In-Chief: Kristin Feeney, B.S. [3]
Overview
Migraine headaches, particular those with an aura, have been associated with a patent foramen ovale.
Trial supportive data for patent foramen ovale and migraine
- A recent metanalysis including 18 studies and comprising 2636 patients, found a low-grade positive association between migraines in patients with patent foramen ovale (PFO) [1]. However, the results of this study should be interpreted with cautions, as the individual studies included for the metanalysis were quite heterogeneous. There was some positive association seen in patients of migraine with aura {odds ratio of 3.21(95% CI 2.38–4.70)} but no such relation was seen for patients of migraine without aura
- Another large case control study done to evaluate the association between migraine headaches and patent foramen ovale (PFO) found no significant association between the two [2]. The prevalence of patent foramen ovale (PFO) was similar in case and control (26.4% versus 25.7%;P=0.90). Unlike the metanalysis discussed above, no difference in patent foramen ovale (PFO) prevalence was found in those with migraine with aura and those without (P=0.93).
- Similar results were shown in a large (1101 subjects) multiethnic, elderly, population-based cohort as no increased association was seen between patent foramen ovale (PFO) and migraine [3].
Relationship of patent foramen ovale to familial migraines with aura
In a study done by Wilmshurst et al. with 71 relatives of 20 probands, found a dominant inheritance pattern in atrial shunts (patent foramen ovale and atrial septal defects). This was found to be linked to inheritance of migraine with aura in some families.
References
- ↑ Schwedt TJ, Demaerschalk BM, Dodick DW (2008). "Patent foramen ovale and migraine: a quantitative systematic review". Cephalalgia. 28 (5): 531–40. doi:10.1111/j.1468-2982.2008.01554.x. PMID 18355348.
- ↑ Garg P, Servoss SJ, Wu JC, Bajwa ZH, Selim MH, Dineen A; et al. (2010). "Lack of association between migraine headache and patent foramen ovale: results of a case-control study". Circulation. 121 (12): 1406–12. doi:10.1161/CIRCULATIONAHA.109.895110. PMID 20231534.
- ↑ Rundek T, Elkind MS, Di Tullio MR, Carrera E, Jin Z, Sacco RL; et al. (2008). "Patent foramen ovale and migraine: a cross-sectional study from the Northern Manhattan Study (NOMAS)". Circulation. 118 (14): 1419–24. doi:10.1161/CIRCULATIONAHA.108.771303. PMC 2737546. PMID 18794393.