Patent foramen ovale epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Priyamvada Singh, M.B.B.S. [2]; Assistant Editor-In-Chief: Kristin Feeney, B.S. [3]

Overview

Approximately 1 in every three normal adults have a patent foramen ovale.[1]

Epidemiology and Demographics

The incidence of Patent foramen ovale has been found to be approximately 30% in different studies.[1]

Age

  • Incidence has been found to vary with age, with Patent foramen ovale (PFO) occuring with higher incidences in patients up to 30 years of age (34.3%) while it decreased in patients between 40 to 80 years of age (25.4%) and was least in patients in their 90s (20.2%). [2]
  • The size has been found to increase with age, from a mean of approximately 3mm in the first decade to approximately 6 mm in the 10th decade of life. [2]

Size

  • The size of patent foramen ovale might range from 1 to 19 mm. However, in most cases it has been found to vary from 1 to 10 mm in diameter. The size has been found to increase with age. [2]

Sex

  • No significant difference in size and incidence based on sex was seen.

References

  1. 1.0 1.1 Meissner I, Whisnant JP, Khandheria BK, Spittell PC, O'Fallon WM, Pascoe RD; et al. (1999). "Prevalence of potential risk factors for stroke assessed by transesophageal echocardiography and carotid ultrasonography: the SPARC study. Stroke Prevention: Assessment of Risk in a Community". Mayo Clin Proc. 74 (9): 862–9. PMID 10488786.
  2. 2.0 2.1 2.2 Hagen PT, Scholz DG, Edwards WD (1984). "Incidence and size of patent foramen ovale during the first 10 decades of life: an autopsy study of 965 normal hearts". Mayo Clin Proc. 59 (1): 17–20. PMID 6694427.