Glucose-6-phosphate dehydrogenase deficiency history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [2]
Overview
The majority of patients with [disease name] are asymptomatic.
OR
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. Common symptoms of [disease] include [symptom 1], [symptom 2], and [symptom 3]. Less common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
History and Symptoms
- The majority of patients with G6PD deficiency are asymptomatic.
- The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
- Symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
History
Patients with G6PD deficiency may have a positive history of:
- Similar problems in family
- [History finding 2]
- [History finding 3]
Common Symptoms
Common symptoms of G6PD include:
- Acute intravascular hemolysis 5 to 24 hours after ingestion fava beans ( favism):[1]
- Most in male children ( ages1-5 years)
- Hedache
- Nausea
- Back pain
- Chils
- Fever
- Jaundice
- Feeling tired
- [Symptom 3]
Less Common Symptoms
Less common symptoms of [disease name] include[2]
- Acute renal failure[3]
- Shortness of breath
References
- ↑ Luzzatto L, Arese P (January 2018). "Favism and Glucose-6-Phosphate Dehydrogenase Deficiency". N. Engl. J. Med. 378 (1): 60–71. PMID 29298156.
- ↑ Burka ER, Weaver Z, Marks PA (April 1966). "Clinical spectrum of hemolytic anemia associated with glucose-6-phosphate dehydrogenase deficiency". Ann. Intern. Med. 64 (4): 817–25. PMID 23841200.
- ↑ Whelton A, Donadio JV, Elisberg BL (August 1968). "Acute renal failure complicating rickettsial infections in glucose-6-phosphate dehydrogenase-deficient individuals". Ann. Intern. Med. 69 (2): 323–8. PMID 5695625.
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Glucose-6-phosphate dehydrogenase deficiency Microchapters |
|
Differentiating Glucose-6-phosphate dehydrogenase deficiency from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Glucose-6-phosphate dehydrogenase deficiency history and symptoms On the Web |
|
American Roentgen Ray Society Images of Glucose-6-phosphate dehydrogenase deficiency history and symptoms |
|
FDA on Glucose-6-phosphate dehydrogenase deficiency history and symptoms |
|
CDC on Glucose-6-phosphate dehydrogenase deficiency history and symptoms |
|
Glucose-6-phosphate dehydrogenase deficiency history and symptoms in the news |
|
Blogs on Glucose-6-phosphate dehydrogenase deficiency history and symptoms |
|
Directions to Hospitals Treating Glucose-6-phosphate dehydrogenase deficiency |
For patient information, click here
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]; Associate Editor(s)-in-Chief: Mahda Alihashemi M.D. [4] [5] [6] [7] [8] [9] [10] [11] Editor-In-Chief: C. Michael Gibson, M.S., M.D. [12]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.D. [13]
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Overview
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked recessive hereditary disease featuring abnormally low levels of the G6PD enzyme, which plays an important role in red blood cell function. Individuals with the disease may exhibit non-immune hemolytic anemia in response to a number of causes. It is closely linked to favism, a disorder characterized by a hemolytic reaction to consumption of broad beans, with a name derived from the Italian name of the broad bean (fava). Sometimes the name, favism, is alternatively used to refer to the enzyme deficiency as a whole.
History and Symptoms
History
- Patients are almost exclusively male, due to the X-linked pattern of inheritance, but female carriers can be clinically affected due to lyonization where random inactivation of an X-chromosome in certain cells creates a population of G6PD deficient red cells coexisting with normal red cells.
- History of hemolytic crises occurs 2-4 days in response to:
- Certain drugs:
- Primaquine (an antimalarial)
- Sulphonamide antibiotics
- Sulphones (e.g. dapsone, used against leprosy)
- Other sulphur-containing drugs: glibenclamide (an anti-diabetic drug)
- Nitrofurantoin (an antibiotic often used for urinary tract infections)
- Vitamin K analogues
- Several others[1]
- Henna can cause a haemolytic crisis in G6PD deficient infants.[2]
- Certain foods, most notably broad beans
- Illness (severe infections)
- Diabetic ketoacidosis
- Certain drugs:
Symptoms
- Symptoms suggestive of anemia such as fatigue, palpitation
- Prolonged jaundice
- Hemolytic features like dark colored urine
- Abdominal or back pain
- Very severe crises can cause acute renal failure
References
- ↑ "The G6PD Deficiency Homepage -- Table 2". Retrieved 2007-10-28.
- ↑ Raupp P, Hassan JA, Varughese M, Kristiansson B (2001). "Henna causes life threatening haemolysis in glucose-6-phosphate dehydrogenase deficiency". Arch. Dis. Child. 85 (5): 411–2. PMID 11668106.