Sideroblastic anemia epidemiology and demographics
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Incidence
- nce of [disease name] is approximately [number range] per 100,000 individuals worldwide.
- In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.
Prevalence
- The prevalence of sideroblastic anemia is approximately 800 per 100,000 individuals worldwide.
- In [year], the incidence/prevalence of [disease name] was estimated to be [number range] cases per 100,000 individuals worldwide.
- The prevalence of [disease/malignancy] is estimated to be [number] cases annually.
Case-fatality rate/Mortality rate
- In [year], the incidence of [disease name] is approximately [number range] per 100,000 individuals with a case-fatality rate/mortality rate of [number range]%.
- The case-fatality rate/mortality rate of [disease name] is approximately [number range].
Age
- Patients of all age groups may develop sideroblastic anemia.
- Congenital X-linked sideroblastic anemia due to ALAS mutation can remain undiagnosed and then present late in the fourth to eighth decades of life.
- The incidence of acquired sideroblastic anemia increases with age; the median age at diagnosis is 74 years.
- Chronic sideroblastic anemia is usually first diagnosed among middle and older age group.[1]
Race
- There is no racial predilection to sideroblastic anemia.
Gender
- Males are more commonly affected than females in X-linked recessive types of sideroblastic anemia.
- A female would have to inherit 1 abnormal chromosome from each parent to acquire the sideroblastic anemia.
- Primary acquired sideroblastic anemia was found in 60.4% male and 39.6% female.[1]
Region
- The majority of [disease name] cases are reported in [geographical region].
- [Disease name] is a common/rare disease that tends to affect [patient population 1] and [patient population 2].
Developed Countries
Developing Countries
Epidemiology and Demographics
Hereditary sideroblastic anemia, being sex-linked, primarily affects males.
• Primary acquired sideroblastic anemia is usually a disease of the elderly.In 25 bone marrow biopsies of children younger than 13 years from Atlanta, Georgia (United States), with anemia, the prevalence of ringed sideroblasts was 8%. [50]
In France, the prevalence of ringed sideroblasts was 57% in patients with primary MDS. [51] In the United Kingdom, amongst healthy volunteers undergoing bone marrow biopsy, siderotic granules (not ring sideroblasts) were present in 29% of men and 19% of women. [52]
Although usually manifested in childhood, congenital X-linked sideroblastic anemia due to ALAS mutation can remain undiagnosed and then present late in the fourth to eighth decades of life. [53, 54] The median age of occurrence of primary acquired sideroblastic anemia is 74 years. [55]
X-linked recessive types of sideroblastic anemia occur more commonly in males. A female would have to inherit 1 abnormal chromosome from each parent to acquire the disease. Progesterone and pregnancy have been reported to induce relapse of sideroblastic anemia. [