Eosinophilic pneumonia diagnostic criteria
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Priyamvada Singh, M.D. [2]
Overview
Diagnosis
A confident diagnosis of AEP can usually be made without a lung biopsy in patients who meet the following criteria: [7,8,58,62]:
- A febrile illness of short duration (one month or less, but often less than one week)
- Hypoxemic respiratory failure (eg, pulse oxygen saturation [SpO2] <90 percent on room air or arterial oxygen tension [PaO2] <60 mmHg)
- Diffuse pulmonary opacities on chest radiograph
- BAL differential cell count showing eosinophilia >25 percent
- Absence of known causes of eosinophilic pneumonia, including drugs, infections, asthma, or atopic disease (table 1) (see "Causes of pulmonary eosinophilia")