Hypolipoproteinemia

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Lipid Disorders Main Page

Overview

Causes

Classification

Abetalipoproteinemia
Hypobetalipoproteinemia
Familial hypoalphalipoproteinemia
LCAT Deficiency
Chylomicron retention disease
Tangier disease
Familial combined hypolipidemia

Differential Diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]; Aravind Kuchkuntla, M.B.B.S[3]; Tarek Nafee, M.D. [4]

Synonyms and keywords: Hypolipidemia, low lipoprotein

Overview

Hypolipoproteinemia is defined as low levels of one or more type of lipoproteins. Hypolipidemia, a commonly used term in the clinical practice, describes low level of lipids, whether cholesterol or triglycerides. They are referred to as hypocholesterolemia and hypotriglyceridemia respectively. Despite being commonly used to describe abnormalities in lipid metabolism, the term hypolipidemia is not very specific. For instance, people who have metabolic syndrome have high LDL and low HDL and yet they are described to have hyperlipidemia when their HDL level is decreased. Moreover, some people who have low levels of a specific lipoprotein may have a normal measured total cholesterol and triglyceride levels.

Synopsis

Disease Gene Demographic Affected lipoprotein Diagnostic Criteria Management
Laboratory Findings Physical Examination Findings

Classification

Shown below is an algorithm depicting the classification of hypolipoproteinemia into primary and secondary.

 
 
 
 
 
 
Hypolipoproteinemia
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Primary
(Genetic)
 
 
 
 
 
 
 
 
 
 
 
 
 
Secondary
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Abetalipoproteinemia
Apolipoprotein 1 deficiency
Chylomicron retention disease
Familial combined hypolipidemia
Hypobetalipoproteinemia
LCAT deficiency
Primary alphalipoproteinemia
PCSK9 deficiency
Tangier disease
 
 
 
 
 
 
 
 
 
 
 
 
 
Anemia
Criticial illness
Chronic inflammation
Chronic liver disease
Hyperthyroidism
Infection
Malabsorption
Malignancy


Approach to Low Cholesterol Level

References


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