Rhabdomyosarcoma pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Microscopic Pathology
Characteristic features on microscopic analysis are variable depending on the chondrosarcoma subtype:
Alveolar Rhabdomyosarcoma
- Characterized by Alveolus-like pattern
- Fibrous septae lined by tumor cells
- Cells may "fall-off" the septa, i.e. be detached/scattered in the alveolus-like space
- Space between fibrous septae may be filled with tumor, called solid variant of alveolar rhabdomyosarcoma
- Rhabdomyoblasts: Essentially diagnostic cells with eccentric nucleus and Moderate amount of intensely eosinophilic cytoplasm
- Nuclear pleomorphism
- Mitoses