Tongue cancer differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Tongue cancer must be differentiated from other diseases that cause malignant lesions of the oral cavity and from few non-neoplastic lesions of the oral cavity, such as lymphoma, adenoid cystic carcinoma, adenocarcinoma, mucoepidermoid carcinoma, rhabdomyosarcoma, liposarcoma, infections at the floor of mouth and mandible, and normal adenoid tissue for lesions at base of tongue.[1]

Differential Diagnosis

The differential diagnosis for a squamous cell carcinoma of the tongue is essentially that of other malignant lesions of the oral cavity as well as a few non-neoplastic lesions. It includes the following:[1]

Site Clinical presentation Investigations Others
Infections Tuberculosis Dorsum
Scarlet fever
Syphilis Dorsum
Benign neoplasms Papilloma Dorsum and lateral borders
Fibroma Dorsum and lateral borders
Rhabdomyoma
Leiomyoma
Schwannoma Dorsum and lateral borders
Neurofibroma Dorsum and lateral borders
Granular cell tumor
Malignant neoplasms Squamous cell carcinotna
Malignant salivary gland tumors Ventral and dorsum
Metastatic tumor
Sarcoma
Idiopathic Benign migratory glossitis Dorsum
Hairy tongue
Metablic Diabetes mellitus
Hypothyroidism
Acromegaly
Vitamin B deficiency Dorsum
Amyloidosis Enlarged tongue

Decrease in lingual mobility

Difficulty in chewing, swallowing and speaking

References

  1. 1.0 1.1 Squamous cell carcinoma of the tongue. Radiopedia(2015) http://radiopaedia.org/articles/squamous-cell-carcinoma-of-the-tongue Accessed on November 16, 2015


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