Fordyce spots

Revision as of 13:03, 27 August 2014 by Jesus Hernandez (talk | contribs)
Jump to navigation Jump to search


WikiDoc Resources for Fordyce spots

Articles

Most recent articles on Fordyce spots

Most cited articles on Fordyce spots

Review articles on Fordyce spots

Articles on Fordyce spots in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Fordyce spots

Images of Fordyce spots

Photos of Fordyce spots

Podcasts & MP3s on Fordyce spots

Videos on Fordyce spots

Evidence Based Medicine

Cochrane Collaboration on Fordyce spots

Bandolier on Fordyce spots

TRIP on Fordyce spots

Clinical Trials

Ongoing Trials on Fordyce spots at Clinical Trials.gov

Trial results on Fordyce spots

Clinical Trials on Fordyce spots at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Fordyce spots

NICE Guidance on Fordyce spots

NHS PRODIGY Guidance

FDA on Fordyce spots

CDC on Fordyce spots

Books

Books on Fordyce spots

News

Fordyce spots in the news

Be alerted to news on Fordyce spots

News trends on Fordyce spots

Commentary

Blogs on Fordyce spots

Definitions

Definitions of Fordyce spots

Patient Resources / Community

Patient resources on Fordyce spots

Discussion groups on Fordyce spots

Patient Handouts on Fordyce spots

Directions to Hospitals Treating Fordyce spots

Risk calculators and risk factors for Fordyce spots

Healthcare Provider Resources

Symptoms of Fordyce spots

Causes & Risk Factors for Fordyce spots

Diagnostic studies for Fordyce spots

Treatment of Fordyce spots

Continuing Medical Education (CME)

CME Programs on Fordyce spots

International

Fordyce spots en Espanol

Fordyce spots en Francais

Business

Fordyce spots in the Marketplace

Patents on Fordyce spots

Experimental / Informatics

List of terms related to Fordyce spots

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Jesus Rosario Hernandez, M.D. [2].

Synonyms and keywords: Fordyce granules; Fordyce disease.

Fordyce spots (also termed Fordyce granules,[1] or Fordyce disease),[1][2] are visible sebaceous glands that are present in most individuals. They appear on the genitals and/or in the mouth. They appear as small, painless, raised, pale, red or white spots or bumps 1 to 3 mm in diameter that may appear on the scrotum, shaft of the penis or on the labia, as well as the inner surface (retromolar mucosa) and vermilion border of the lips of the face. They are not associated with any disease or illness, nor are they infectious but rather they represent a natural occurrence on the body. No treatment is therefore required, unless the individual has cosmetic concerns. Persons with this condition sometimes consult with a dermatologist because they are worried they may have a sexually transmitted disease (especially genital warts) or some form of cancer.[3]

Classification

Sebaceous glands are normal adnexal structures of the dermis but may also be found ectopically within the mouth, where they are referred to as Oral Fordyce Granules or ectopic sebaceous glands. On the foreskin they are called Tyson's glands,[4] not to be confused with hirsuties coronae glandis.[5]

When they appear on the penis, they are also called penile sebaceous glands.[6]

When seen as a streak of individual glands along the interface between the skin of the lip and the vermilion border, the terms Fox-Fordyce disease and Fordyce's condition have been used.

Signs and symptoms

On the shaft of the penis, Fordyce spots are more visible when the skin is stretched, and may only be noticeable during an erection.[6] The spots can also appear on the skin of the scrotum.[6]

Oral Fordyce granules appear as rice-like granules, white or yellow-white in color. They are painless papules (small bumps), about 1–3 mm in greatest dimension. The most common site is along the line between the vermilion border and the oral mucosa of the upper lip, or on the buccal mucosa (inside the cheeks) in the commissural region,[1] often bilaterally. They may also occur on the mandibular retromolar pad and tonsillar areas, but any oral surface may be involved. There is no surrounding mucosal change. Some patients will have hundreds of granules while most have only one or two.

Occasionally, several adjacent glands will coalesce into a larger cauliflower-like cluster similar to sebaceous hyperplasia of the skin. In such an instance, it may be difficult to determine whether or not to diagnose the lesion as sebaceous hyperplasia or sebaceous adenoma. The distinction may be moot because both entities have the same treatment, although the adenoma has a greater growth potential. It should be mentioned that sebaceous carcinoma of the oral cavity has been reported, presumably arising from Fordyce granules or hyperplastic foci of sebaceous glands.

In some persons with Fordyce spots, the glands express a thick, chalky discharge when squeezed.[6]

Causes

Normally, sebaceous glands are only found in association with a hair follicle.

They appear to be more obvious in people with greasy skin types, with some rheumatic disorders, and in Hereditary nonpolyposis colorectal cancer.[1] In the latter, the most common site for Fordyce spots is the lower gingiva (gums) and vestibular mucosa.[1]

Diagnosis

Large numbers of lobules coalescing into a definitely elevated mass may be called benign sebaceous hyperplasia, and occasional small keratin-filled pseudocysts may be seen and must be differentiated from epidermoid cyst or dermoid cyst with sebaceous adnexa. The pathologist must be careful to differentiate such lesions from salivary neoplasms with sebaceous cells, such as sebaceous lymphadenoma and sebaceous adenoma, and their malignant counterparts sebaceous lymphadenocarcinoma and sebaceous carcinoma.

Oral Fordyce granules are usually not biopsied because they are readily diagnosed clinically, but they are often seen as incidental findings of mucosal biopsies of the buccal, labial and retromolar mucosa. The granules are similar to normal sebaceous glands of the skin but lack hair follicles and almost always lack a ductal communication with the surface. The glands are located just beneath the overlying epithelium and often produce a local elevation of the epithelium. Individual sebaceous cells are large, with central dark nuclei and abundant foamy cytoplasm. The surrounding stroma may contain occasional chronic inflammatory cells because of trauma with adjacent teeth.

Physical examination

Gallery

Head

Prognosis

Fordyce spots are completely benign,[1] and require no treatment. Often their presence is considered normal anatomic variants rather than a true medical condition.

Treatment

Vaporising laser treatments such as CO2 laser[7] or electro desiccation have been used with some success in diminishing the appearance of this condition if they are of cosmetic concern, despite the fact that most doctors consider this a normal physiological phenomenon and advise against treatment.[8]

Success varies per patient, but some have found relief from pulsed dye Lasers,[9] a laser normally used to treat sebaceous gland hyperplasia,[10] which is similar to Fordyce spots. Treatment with pulsed dye lasers is expensive, but may be less likely to scar than other methods.[10]

No treatment is required for oral Fordyce granules, except for cosmetic removal of labial lesions if the individual wishes it. Inflamed glands can be treated topically with clindamycin. When surgically excised they will not recur. Neoplastic transformation is very rare but has been reported.

Epidemiology

This variation of normal anatomy is seen in the majority of adults. It is estimated about 80% of people have oral Fordyce spots,[1] but seldom are granules found in large numbers. They are not usually visible in children, and tend to appear at about age 3, then increasing during puberty and become more obvious in later adulthood.[1] They are more prominent in males.[1] Examples reported in a cancer screening represent approximately 1% of adults.

History

They are named after an American dermatologist, John Addison Fordyce.[11]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Scully C (2013). Oral and maxillofacial medicine : the basis of diagnosis and treatment (3rd ed.). Edinburgh: Churchill Livingstone. pp. 170, 392. ISBN 978-0-7020-4948-4.
  2. James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.Template:Pn
  3. Palo Alto Medical Foundation Bettina McAdoo , M.D. Retrieved June 24, 2006.
  4. derm/395 at eMedicine
  5. Khoo LS, Cheong WK (July 1995). "Common genital dermatoses in male patients attending a public sexually transmitted disease clinic in Singapore". Annals of the Academy of Medicine, Singapore. 24 (4): 505–9. PMID 8849177.
  6. 6.0 6.1 6.2 6.3 Rane V, Read T (May 2013). "Penile appearance, lumps and bumps". Australian Family Physician. 42 (5): 270–4. PMID 23781523.
  7. Ocampo-Candiani J, Villarreal-Rodríguez A, Quiñones-Fernández AG, Herz-Ruelas ME, Ruíz-Esparza J (August 2003). "Treatment of Fordyce spots with CO2 laser". Dermatologic Surgery. 29 (8): 869–71. doi:10.1046/j.1524-4725.2003.29236.x. PMID 12859392.
  8. Nordqvist, Christian (February 27, 2013). "What Are Fordyce Spots? What Causes Fordyce Spots?". Medical News Today.
  9. http://sebaceous.proboards42.com/index.cgi?board=real&action=display&thread=249&page=5[full citation needed]
  10. 10.0 10.1 Schönermark MP, Schmidt C, Raulin C (1997). "Treatment of sebaceous gland hyperplasia with the pulsed dye laser". Lasers in Surgery and Medicine. 21 (4): 313–6. doi:10.1002/(SICI)1096-9101(1997)21:4<313::AID-LSM1>3.0.CO;2-T. PMID 9328977.
  11. Fordyce first described this condition in 1896.Template:WhoNamedIt