Wolff-Parkinson-White syndrome overview: Difference between revisions
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==Overview== | ==Overview== | ||
Wolff-Parkinson-White syndrome (WPW) is a syndrome of pre-excitation of the [[Ventricle (heart)|ventricles]] of the [[heart]] due to an [[accessory pathway]] known as the ''[[Bundle of Kent]]''. This accessory pathway is | Wolff-Parkinson-White syndrome (WPW) is a syndrome of pre-excitation of the [[Ventricle (heart)|ventricles]] of the [[heart]] due to an [[accessory pathway]] known as the ''[[Bundle of Kent]]''. This accessory pathway is a congenital abnormal electrical communication from the [[atrium (anatomy)|atria]] to the [[ventricles]] causing them to contract prematurely, resulting in a unique type of [[supraventricular tachycardia]] referred to as an [[Supraventricular_tachycardia#Types|atrioventricular reciprocating tachycardia]]. The accessory pathway is the consequence of the lack of complete fushion between the suculus and the endocardiac cushion tissue which should be completed by the 12th week of gestation.<ref name="WesselsMarkman1996">{{cite journal|last1=Wessels|first1=A.|last2=Markman|first2=M.W.M.|last3=Vermeulen|first3=J.L.M.|last4=Anderson|first4=R.H.|last5=Moorman|first5=A.F.M.|last6=Lamers|first6=W.H.|title=The Development of the Atrioventricular Junction in the Human Heart|journal=Circulation Research|volume=78|issue=1|year=1996|pages=110–117|issn=0009-7330|doi=10.1161/01.RES.78.1.110}}</ref><ref name="Ho2008">{{cite journal|last1=Ho|first1=S. Y.|title=Accessory Atrioventricular Pathways: Getting to the Origins|journal=Circulation|volume=117|issue=12|year=2008|pages=1502–1504|issn=0009-7322|doi=10.1161/CIRCULATIONAHA.107.764035}}</ref> | ||
The incidence of WPW syndrome is between 0.1 and 3% of the general population.<ref name = Rosner_et_al_1999> | The incidence of WPW syndrome is between 0.1 and 3% of the general population.<ref name = Rosner_et_al_1999> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]
Overview
Wolff-Parkinson-White syndrome (WPW) is a syndrome of pre-excitation of the ventricles of the heart due to an accessory pathway known as the Bundle of Kent. This accessory pathway is a congenital abnormal electrical communication from the atria to the ventricles causing them to contract prematurely, resulting in a unique type of supraventricular tachycardia referred to as an atrioventricular reciprocating tachycardia. The accessory pathway is the consequence of the lack of complete fushion between the suculus and the endocardiac cushion tissue which should be completed by the 12th week of gestation.[1][2]
The incidence of WPW syndrome is between 0.1 and 3% of the general population.[3][4][5]
While the vast majority of individuals with WPW syndrome remain asymptomatic throughout their entire lives, there is a risk of sudden death associated with the syndrome. Sudden death due to WPW syndrome is rare (incidence of less than 0.6%[5][6]), and is due to the effect of the accessory pathway on tachyarrhythmias in these individuals.
References
- ↑ Wessels, A.; Markman, M.W.M.; Vermeulen, J.L.M.; Anderson, R.H.; Moorman, A.F.M.; Lamers, W.H. (1996). "The Development of the Atrioventricular Junction in the Human Heart". Circulation Research. 78 (1): 110–117. doi:10.1161/01.RES.78.1.110. ISSN 0009-7330.
- ↑ Ho, S. Y. (2008). "Accessory Atrioventricular Pathways: Getting to the Origins". Circulation. 117 (12): 1502–1504. doi:10.1161/CIRCULATIONAHA.107.764035. ISSN 0009-7322.
- ↑ Rosner MH, Brady WJ Jr, Kefer MP, Martin ML. (1999). "Electrocardiography in the patient with the Wolff-Parkinson-White syndrome: diagnostic and initial therapeutic issues". American Journal of Emergency Medicine. 17 (7): 705–14. PMID 10597097.
- ↑ Sorbo MD, Buja GF, Miorelli M, Nistri S, Perrone C, Manca S, Grasso F, Giordano GM, Nava A. (1995). "The prevalence of the Wolff-Parkinson-White syndrome in a population of 116,542 young males". Giornale Italiano di Cardiologia (in Italian). 25 (6): 681–7. PMID 7649416.
- ↑ 5.0 5.1 Munger TM, Packer DL, Hammill SC, Feldman BJ, Bailey KR, Ballard DJ, Holmes DR Jr, Gersh BJ. (1993). "A population study of the natural history of Wolff-Parkinson-White syndrome in Olmsted County, Minnesota, 1953-1989". Circulation. 87 (3): 866–73. PMID 8443907.
- ↑ Fitzsimmons PJ, McWhirter PD, Peterson DW, Kruyer WB (2001). "The natural history of Wolff-Parkinson-White syndrome in 228 military aviators: a long-term follow-up of 22 years". American Heart Journal. 142 (3): 530–6. PMID 11526369 doi:10.1067/mhj.2001.117779.