Traumatic brain injury laboratory findings: Difference between revisions

Jump to navigation Jump to search
No edit summary
Line 3: Line 3:
{{CMG}} {{JE}}
{{CMG}} {{JE}}
==Overview==
==Overview==
An elevated concentration of CSF spectrin breakdown product (SBDP)120 and SBDP145, ubiquitin C-terminal hydrolase-L1 (UCH-L1), and glial fibrillary acidic protein (GFAP) is diagnostic of traumatic brain injury.
Laboratory findings have little to no utility of diagnostic importance to the TBI. They may however, be useful, in case patient needs emergent surgery.  
==Laboratory Findings==
==Laboratory Findings==
An elevated concentration of the following in CSF is diagnostic of traumatic brain injury.<ref name="pmid21171922">{{cite journal| author=Mondello S, Muller U, Jeromin A, Streeter J, Hayes RL, Wang KK| title=Blood-based diagnostics of traumatic brain injuries. | journal=Expert Rev Mol Diagn | year= 2011 | volume= 11 | issue= 1 | pages= 65-78 | pmid=21171922 | doi=10.1586/erm.10.104 | pmc=3063529 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21171922  }} </ref>
One of the rare but very interesting finding that one can see in laboratory evaluation would be hyponatremia. An elevated intracranial pressure can induce natriuresis and lead to hyponatremia in very rare cases. But otherwise, the important laboratory investigations to get complete blood count, comprehensive metabolic panel, PT/INR and PTT in case patient needs emergent surgery. CSF analysis is not done in clinical practice, as a lumbar puncture carries higher risk of herniation and the analysis itself is not particularly useful. But you can see the following abnormal findings in the CSF<ref name="pmid21171922">{{cite journal| author=Mondello S, Muller U, Jeromin A, Streeter J, Hayes RL, Wang KK| title=Blood-based diagnostics of traumatic brain injuries. | journal=Expert Rev Mol Diagn | year= 2011 | volume= 11 | issue= 1 | pages= 65-78 | pmid=21171922 | doi=10.1586/erm.10.104 | pmc=3063529 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21171922  }} </ref>
 
*Spectrin breakdown product (SBDP)120 and SBDP145
*Spectrin breakdown product (SBDP)120 and SBDP145
*Ubiquitin C-terminal hydrolase-L1 (UCH-L1)
*Ubiquitin C-terminal hydrolase-L1 (UCH-L1)

Revision as of 19:57, 27 August 2021

Traumatic brain injury Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Traumatic Brain Injury from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Neurocognitive Disorder due to Traumatic Brain Injury

Diagnosis

Diagnostic study of choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X Ray

Echocardiography and Ultrasound

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Interventions

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Traumatic brain injury laboratory findings On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Traumatic brain injury laboratory findings

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Traumatic brain injury laboratory findings

CDC on Traumatic brain injury laboratory findings

Traumatic brain injury laboratory findings in the news

Blogs on Traumatic brain injury laboratory findings

Directions to Hospitals Treating Traumatic brain injury

Risk calculators and risk factors for Traumatic brain injury laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Joanna Ekabua, M.D. [2]

Overview

Laboratory findings have little to no utility of diagnostic importance to the TBI. They may however, be useful, in case patient needs emergent surgery.

Laboratory Findings

One of the rare but very interesting finding that one can see in laboratory evaluation would be hyponatremia. An elevated intracranial pressure can induce natriuresis and lead to hyponatremia in very rare cases. But otherwise, the important laboratory investigations to get complete blood count, comprehensive metabolic panel, PT/INR and PTT in case patient needs emergent surgery. CSF analysis is not done in clinical practice, as a lumbar puncture carries higher risk of herniation and the analysis itself is not particularly useful. But you can see the following abnormal findings in the CSF[1]

  • Spectrin breakdown product (SBDP)120 and SBDP145
  • Ubiquitin C-terminal hydrolase-L1 (UCH-L1)
  • Glial fibrillary acidic protein (GFAP)

References

  1. Mondello S, Muller U, Jeromin A, Streeter J, Hayes RL, Wang KK (2011). "Blood-based diagnostics of traumatic brain injuries". Expert Rev Mol Diagn. 11 (1): 65–78. doi:10.1586/erm.10.104. PMC 3063529. PMID 21171922.


Template:WikiDoc Sources