Acrodermatitis chronica atrophicans laboratory findings: Difference between revisions
Jump to navigation
Jump to search
| Line 7: | Line 7: | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
*[[ | *Since [[diagnosis]] of [[acrodermatitis chronica atrophicans]] could be dificult due to various presentations, [[physicians]] can use [[serology|serologic]] and [[histology|histologic]] examination to confirm it.<ref name="pmid33550695">{{cite journal| author=Ogrinc K, Maraspin V, Lusa L, Cerar Kišek T, Ružić-Sabljić E, Strle F| title=Acrodermatitis chronica atrophicans: clinical and microbiological characteristics of a cohort of 693 Slovenian patients. | journal=J Intern Med | year= 2021 | volume= | issue= | pages= | pmid=33550695 | doi=10.1111/joim.13266 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33550695 }} </ref><ref name="Muller2012">{{cite journal|last1=Muller|first1=Kurt E.|title=Damage of Collagen and Elastic Fibres by Borrelia Burgdorferi – Known and New Clinical and Histopathological Aspects|journal=The Open Neurology Journal|volume=6|issue=1|year=2012|pages=179–186|issn=1874205X|doi=10.2174/1874205X01206010179}}</ref> | ||
*High anti-[[Spirochaete|spirochetal]] [[antibody]] levels (both [[Immunoglobulin G|IgG]] and [[Immunoglobulin G|IgM]]) has been detected at indirect [[immunofluorescence]] and [[enzyme linked immunosorbent assay (ELISA)]].<ref name="pmid3577484">{{cite journal| author=Asbrink E, Hovmark A, Olsson I| title=Clinical manifestations of acrodermatitis chronica atrophicans in 50 Swedish patients. | journal=Zentralbl Bakteriol Mikrobiol Hyg A | year= 1986 | volume= 263 | issue= 1-2 | pages= 253-61 | pmid=3577484 | doi=10.1016/s0176-6724(86)80128-6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3577484 }} </ref><ref name="pmid2715325">{{cite journal| author=Hansen K, Asbrink E| title=Serodiagnosis of erythema migrans and acrodermatitis chronica atrophicans by the Borrelia burgdorferi flagellum enzyme-linked immunosorbent assay. | journal=J Clin Microbiol | year= 1989 | volume= 27 | issue= 3 | pages= 545-51 | pmid=2715325 | doi=10.1128/jcm.27.3.545-551.1989 | pmc=267355 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2715325 }} </ref><ref name="pmid33550695">{{cite journal| author=Ogrinc K, Maraspin V, Lusa L, Cerar Kišek T, Ružić-Sabljić E, Strle F| title=Acrodermatitis chronica atrophicans: clinical and microbiological characteristics of a cohort of 693 Slovenian patients. | journal=J Intern Med | year= 2021 | volume= | issue= | pages= | pmid=33550695 | doi=10.1111/joim.13266 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33550695 }} </ref> | *High anti-[[Spirochaete|spirochetal]] [[antibody]] levels (both [[Immunoglobulin G|IgG]] and [[Immunoglobulin G|IgM]]) has been detected at indirect [[immunofluorescence]] and [[enzyme linked immunosorbent assay (ELISA)]].<ref name="pmid3577484">{{cite journal| author=Asbrink E, Hovmark A, Olsson I| title=Clinical manifestations of acrodermatitis chronica atrophicans in 50 Swedish patients. | journal=Zentralbl Bakteriol Mikrobiol Hyg A | year= 1986 | volume= 263 | issue= 1-2 | pages= 253-61 | pmid=3577484 | doi=10.1016/s0176-6724(86)80128-6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3577484 }} </ref><ref name="pmid2715325">{{cite journal| author=Hansen K, Asbrink E| title=Serodiagnosis of erythema migrans and acrodermatitis chronica atrophicans by the Borrelia burgdorferi flagellum enzyme-linked immunosorbent assay. | journal=J Clin Microbiol | year= 1989 | volume= 27 | issue= 3 | pages= 545-51 | pmid=2715325 | doi=10.1128/jcm.27.3.545-551.1989 | pmc=267355 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2715325 }} </ref><ref name="pmid33550695">{{cite journal| author=Ogrinc K, Maraspin V, Lusa L, Cerar Kišek T, Ružić-Sabljić E, Strle F| title=Acrodermatitis chronica atrophicans: clinical and microbiological characteristics of a cohort of 693 Slovenian patients. | journal=J Intern Med | year= 2021 | volume= | issue= | pages= | pmid=33550695 | doi=10.1111/joim.13266 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33550695 }} </ref> | ||
*Among various [[antigens]] in [[borrelia burgdorferi]], [[flagellum]] [[antigen]] is one of the recommended [[serology|serologic evaluation]] in [[Acrodermatitis chronica atrophicans|acrodermatitis chronica atrophicans]] [[patients]]. Moreover checking [[Immunoglobulin G|IgG]] against [[borrelia burgdorferi|borrelia]] are more specific compared to [[Immunoglobulin M|IgM]].<ref name="pmid2715325">{{cite journal| author=Hansen K, Asbrink E| title=Serodiagnosis of erythema migrans and acrodermatitis chronica atrophicans by the Borrelia burgdorferi flagellum enzyme-linked immunosorbent assay. | journal=J Clin Microbiol | year= 1989 | volume= 27 | issue= 3 | pages= 545-51 | pmid=2715325 | doi=10.1128/jcm.27.3.545-551.1989 | pmc=267355 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2715325 }} </ref> | *Among various [[antigens]] in [[borrelia burgdorferi]], [[flagellum]] [[antigen]] is one of the recommended [[serology|serologic evaluation]] in [[Acrodermatitis chronica atrophicans|acrodermatitis chronica atrophicans]] [[patients]]. Moreover checking [[Immunoglobulin G|IgG]] against [[borrelia burgdorferi|borrelia]] are more specific compared to [[Immunoglobulin M|IgM]].<ref name="pmid2715325">{{cite journal| author=Hansen K, Asbrink E| title=Serodiagnosis of erythema migrans and acrodermatitis chronica atrophicans by the Borrelia burgdorferi flagellum enzyme-linked immunosorbent assay. | journal=J Clin Microbiol | year= 1989 | volume= 27 | issue= 3 | pages= 545-51 | pmid=2715325 | doi=10.1128/jcm.27.3.545-551.1989 | pmc=267355 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2715325 }} </ref> | ||
Revision as of 01:34, 11 June 2021
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anahita Deylamsalehi, M.D.[2] Raviteja Guddeti, M.B.B.S. [3]
|
Acrodermatitis chronica atrophicans Microchapters |
|
Differentiating Acrodermatitis chronica atrophicans from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Acrodermatitis chronica atrophicans laboratory findings On the Web |
|
American Roentgen Ray Society Images of Acrodermatitis chronica atrophicans laboratory findings |
|
FDA on Acrodermatitis chronica atrophicans laboratory findings |
|
CDC on Acrodermatitis chronica atrophicans laboratory findings |
|
Acrodermatitis chronica atrophicans laboratory findings in the news |
|
Blogs on Acrodermatitis chronica atrophicans laboratory findings |
|
Risk calculators and risk factors for Acrodermatitis chronica atrophicans laboratory findings |
Overview
An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of acrodermatitis chronica atrophicans.
Laboratory Findings
- Since diagnosis of acrodermatitis chronica atrophicans could be dificult due to various presentations, physicians can use serologic and histologic examination to confirm it.[1][2]
- High anti-spirochetal antibody levels (both IgG and IgM) has been detected at indirect immunofluorescence and enzyme linked immunosorbent assay (ELISA).[3][4][1]
- Among various antigens in borrelia burgdorferi, flagellum antigen is one of the recommended serologic evaluation in acrodermatitis chronica atrophicans patients. Moreover checking IgG against borrelia are more specific compared to IgM.[4]
- Based on various studied cases there is no relation between anti-spirochetal IgG and inflammatory cell concentration (such as plasma cell concentration).
- Borrelia itself has been found in some of the skin samples. In a study done on 693 patients suffering from acrodermatitis chronica atrophicans, 30.1% of samples were positive for borrelia. [1]
- Borrelia can grew in skin culture even after 10 years of active disease, which is an evidence of borrelia ability to survive for a long period.[5]
- Negative skin culture for borrelia doens't exclude the diagnosis.[6]
- A study done on patients with acrodermatitis chronica atrophicans revealed rheumatoid factor in 32% of patients.[4]
- Elevated levels of ESR could be seen in these patients.[6]
- Biopsy shows chronic inflammatory signs in chronic cases. Other histological finding are listed below: [7][3][6]
- Perivascular lymphocytic infiltration
- Plasma cells
- Histiocytes
- Telangiectasia
- Pigmented stratum germinativum
- Dermis and epidermis thinning
References
- ↑ 1.0 1.1 1.2 Ogrinc K, Maraspin V, Lusa L, Cerar Kišek T, Ružić-Sabljić E, Strle F (2021). "Acrodermatitis chronica atrophicans: clinical and microbiological characteristics of a cohort of 693 Slovenian patients". J Intern Med. doi:10.1111/joim.13266. PMID 33550695 Check
|pmid=value (help). - ↑ Muller, Kurt E. (2012). "Damage of Collagen and Elastic Fibres by Borrelia Burgdorferi – Known and New Clinical and Histopathological Aspects". The Open Neurology Journal. 6 (1): 179–186. doi:10.2174/1874205X01206010179. ISSN 1874-205X.
- ↑ 3.0 3.1 Asbrink E, Hovmark A, Olsson I (1986). "Clinical manifestations of acrodermatitis chronica atrophicans in 50 Swedish patients". Zentralbl Bakteriol Mikrobiol Hyg A. 263 (1–2): 253–61. doi:10.1016/s0176-6724(86)80128-6. PMID 3577484.
- ↑ 4.0 4.1 4.2 Hansen K, Asbrink E (1989). "Serodiagnosis of erythema migrans and acrodermatitis chronica atrophicans by the Borrelia burgdorferi flagellum enzyme-linked immunosorbent assay". J Clin Microbiol. 27 (3): 545–51. doi:10.1128/jcm.27.3.545-551.1989. PMC 267355. PMID 2715325.
- ↑ Åsbrink, Eva; Hovmark, Anders (2009). "Successful Cultivation of Spirochetes from Skin Lesions of Patients With Erythema Chronicum Migrans Afzelius and Acrodermatitis Chronica Atrophicans". Acta Pathologica Microbiologica Scandinavica Series B: Microbiology. 93B (1–6): 161–163. doi:10.1111/j.1699-0463.1985.tb02870.x. ISSN 0108-0180.
- ↑ 6.0 6.1 6.2 Nadal, D; Gundelfinger, R; Flueler, U; Boltshauser, E (1988). "Acrodermatitis chronica atrophicans". Archives of Disease in Childhood. 63 (1): 72–74. doi:10.1136/adc.63.1.72. ISSN 0003-9888.
- ↑ Rosenlund S, Bækgaard N, Menné T (2011). "[Acrodermatitis chronica atrophicans can be difficult to diagnose]". Ugeskr. Laeg. (in Danish). 173 (50): 3272–3. PMID 22153213. Unknown parameter
|month=ignored (help)