Scleroderma risk factors: Difference between revisions
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*Common risk factors in the development of scleroderma include occupational exposure to certain chemicals, certain [[genetic]] variations and [[infectious]] agents. | *Common risk factors in the development of scleroderma include occupational exposure to certain chemicals, certain [[genetic]] variations and [[infectious]] agents. | ||
===Common Risk Factors=== | ===Common Risk Factors=== | ||
Common risk factors in the development of scleroderma may be occupational, environmental, [[genetic]], and [[infectious]]: | |||
*Occupational and environmental exposure to:<ref name="pmid12151611">{{cite journal |vauthors=Diot E, Lesire V, Guilmot JL, Metzger MD, Pilore R, Rogier S, Stadler M, Diot P, Lemarie E, Lasfargues G |title=Systemic sclerosis and occupational risk factors: a case-control study |journal=Occup Environ Med |volume=59 |issue=8 |pages=545–9 |date=August 2002 |pmid=12151611 |pmc=1740346 |doi= |url=}}</ref><ref name="pmid22269658">{{cite journal |vauthors=Barnes J, Mayes MD |title=Epidemiology of systemic sclerosis: incidence, prevalence, survival, risk factors, malignancy, and environmental triggers |journal=Curr Opin Rheumatol |volume=24 |issue=2 |pages=165–70 |date=March 2012 |pmid=22269658 |doi=10.1097/BOR.0b013e32834ff2e8 |url=}}</ref><ref name="pmid23287382">{{cite journal |vauthors=Dospinescu P, Jones GT, Basu N |title=Environmental risk factors in systemic sclerosis |journal=Curr Opin Rheumatol |volume=25 |issue=2 |pages=179–83 |date=March 2013 |pmid=23287382 |doi=10.1097/BOR.0b013e32835cfc2d |url=}}</ref><ref name="pmid24129037">{{cite journal |vauthors=Marie I, Gehanno JF, Bubenheim M, Duval-Modeste AB, Joly P, Dominique S, Bravard P, Noël D, Cailleux AF, Weber J, Lagoutte P, Benichou J, Levesque H |title=Prospective study to evaluate the association between systemic sclerosis and occupational exposure and review of the literature |journal=Autoimmun Rev |volume=13 |issue=2 |pages=151–6 |date=February 2014 |pmid=24129037 |doi=10.1016/j.autrev.2013.10.002 |url=}}</ref> | |||
**Crystaline [[silica]] | |||
**Trichlorethylene | |||
**Chlorinated [[solvents]] | |||
**[[Toluene]] | |||
**[[Aromatic]] [[solvents]] | |||
**[[Ketones]] | |||
**White spirit | |||
**[[Epoxy resins]] | |||
**Welding [[fumes]] | |||
*[[Genetic]] variations in:<ref name="urlSystemic scleroderma - Genetics Home Reference,US national library of medicine">{{cite web |url=https://ghr.nlm.nih.gov/condition/systemic-scleroderma#sourcesforpage |title=Systemic scleroderma - Genetics Home Reference |format= |work= |accessdate=}}</ref> | |||
**[[Human leukocyte antigens|Human leukocyte antigen (HLA) genes]] | |||
**[[IRF5]] [[gene]] | |||
**[[STAT4]] [[gene]] | |||
*[[Infectious]] agents:<ref name="pmid21158008">{{cite journal |vauthors=Radić M, Martinović Kaliterna D, Radić J |title=Infectious disease as aetiological factor in the pathogenesis of systemic sclerosis |journal=Neth J Med |volume=68 |issue=11 |pages=348–53 |date=November 2010 |pmid=21158008 |doi= |url=}}</ref><ref name="pmid19758208">{{cite journal |vauthors=Arnson Y, Amital H, Guiducci S, Matucci-Cerinic M, Valentini G, Barzilai O, Maya R, Shoenfeld Y |title=The role of infections in the immunopathogensis of systemic sclerosis--evidence from serological studies |journal=Ann. N. Y. Acad. Sci. |volume=1173 |issue= |pages=627–32 |date=September 2009 |pmid=19758208 |doi=10.1111/j.1749-6632.2009.04808.x |url=}}</ref> | |||
**[[Cytomegalovirus]] ([[CMV]]) | |||
**[[Hepatitis B virus]] ([[HBV]]) | |||
**[[Toxoplasma gondii]] infection ([[toxoplasmosis]]) | |||
===Less Common Risk Factors=== | ===Less Common Risk Factors=== | ||
Revision as of 17:16, 28 March 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: M. Khurram Afzal, MD [2]
Overview
Common risk factors in the development of scleroderma include occupational and environmental exposure to certain chemicals, certain genetic variations and infectious agents. Most commonly implicated occupational and environmental risk factors are exposure is to silica, chlorinated and aromatic solvents as well as welding fumes.
Risk Factors
- Common risk factors in the development of scleroderma include occupational exposure to certain chemicals, certain genetic variations and infectious agents.
Common Risk Factors
Common risk factors in the development of scleroderma may be occupational, environmental, genetic, and infectious:
- Occupational and environmental exposure to:[1][2][3][4]
- Genetic variations in:[5]
- Infectious agents:[6][7]
- Cytomegalovirus (CMV)
- Hepatitis B virus (HBV)
- Toxoplasma gondii infection (toxoplasmosis)
Less Common Risk Factors
Less common risk factors in the development of scleroderma include:
References
- ↑ Diot E, Lesire V, Guilmot JL, Metzger MD, Pilore R, Rogier S, Stadler M, Diot P, Lemarie E, Lasfargues G (August 2002). "Systemic sclerosis and occupational risk factors: a case-control study". Occup Environ Med. 59 (8): 545–9. PMC 1740346. PMID 12151611.
- ↑ Barnes J, Mayes MD (March 2012). "Epidemiology of systemic sclerosis: incidence, prevalence, survival, risk factors, malignancy, and environmental triggers". Curr Opin Rheumatol. 24 (2): 165–70. doi:10.1097/BOR.0b013e32834ff2e8. PMID 22269658.
- ↑ 3.0 3.1 Dospinescu P, Jones GT, Basu N (March 2013). "Environmental risk factors in systemic sclerosis". Curr Opin Rheumatol. 25 (2): 179–83. doi:10.1097/BOR.0b013e32835cfc2d. PMID 23287382.
- ↑ Marie I, Gehanno JF, Bubenheim M, Duval-Modeste AB, Joly P, Dominique S, Bravard P, Noël D, Cailleux AF, Weber J, Lagoutte P, Benichou J, Levesque H (February 2014). "Prospective study to evaluate the association between systemic sclerosis and occupational exposure and review of the literature". Autoimmun Rev. 13 (2): 151–6. doi:10.1016/j.autrev.2013.10.002. PMID 24129037.
- ↑ "Systemic scleroderma - Genetics Home Reference".
- ↑ Radić M, Martinović Kaliterna D, Radić J (November 2010). "Infectious disease as aetiological factor in the pathogenesis of systemic sclerosis". Neth J Med. 68 (11): 348–53. PMID 21158008.
- ↑ Arnson Y, Amital H, Guiducci S, Matucci-Cerinic M, Valentini G, Barzilai O, Maya R, Shoenfeld Y (September 2009). "The role of infections in the immunopathogensis of systemic sclerosis--evidence from serological studies". Ann. N. Y. Acad. Sci. 1173: 627–32. doi:10.1111/j.1749-6632.2009.04808.x. PMID 19758208.
- ↑ De Martinis M, Ciccarelli F, Sirufo MM, Ginaldi L (2016). "An overview of environmental risk factors in systemic sclerosis". Expert Rev Clin Immunol. 12 (4): 465–78. doi:10.1586/1744666X.2016.1125782. PMID 26610037.