Tabes Dorsalis natural history, complications, and prognosis: Difference between revisions
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*[[Charcot joint|Charcot arthropathy]]([[Charcot joint]]) of the foot may be seen | *[[Charcot joint|Charcot arthropathy]]([[Charcot joint]]) of the foot may be seen | ||
*Broad base gate and [[Sensory ataxia|Sensory ataxic gait]] is usually seen in patients with tabes dorsalis | *Broad base gate and [[Sensory ataxia|Sensory ataxic gait]] is usually seen in patients with tabes dorsalis | ||
===Prognosis=== | |||
Prognosis varies by site of involvement and duration of disease: | |||
* 90% of patients with [[neurosyphilis]] respond to treatment. | |||
* [[Gummatous]] lesions reverse with treatment. | |||
* Mortality rates are high with cardiovascular complications. | |||
* 20% of patients with [[Tertiary syphilis|neurosyphilis]] die of complications. | |||
==References== | ==References== | ||
Revision as of 19:08, 28 February 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
The symptoms of tabes dorsalis usually develop secondary to long-term untreated syphilis, and start with symptoms such as lightning pains, impaired sensation and proprioception and hypesthesias. Common complications of tabes dorsalis include Dementia, stroke, eye disease, Paralysis, and Charcot arthropathy(Charcot joint).
Natural History, Complications, and Prognosis
Natural History
The symptoms of tabes dorsalis usually develop secondary to long-term untreated syphilis, and start with symptoms such as;
- Lightning pains[1]
- Impaired sensation and proprioception[2]
- Hypesthesias[3].
The symptoms of tabes dorsalis typically occurs 10 to 30 years after primary infection by treponema pallidum.[4]
If left untreated, most patients with tabes dorsalis may progress to develop paralysis, dementia, and blindness.
Complications
Common complications of tabes dorsalis include:[5][6]
- Charcot arthropathy(Charcot joint) of the foot may be seen
- Broad base gate and Sensory ataxic gait is usually seen in patients with tabes dorsalis
Prognosis
Prognosis varies by site of involvement and duration of disease:
- 90% of patients with neurosyphilis respond to treatment.
- Gummatous lesions reverse with treatment.
- Mortality rates are high with cardiovascular complications.
- 20% of patients with neurosyphilis die of complications.
References
- ↑ MAO S, LIU Z (2009). "Neurosyphilis manifesting as lightning pain". Eur J Dermatol. 19 (5): 504–6. doi:10.1684/ejd.2009.0712. PMID 19487174.
- ↑ Vora SK, Lyons RW (2004). "The medical Kipling--syphilis, tabes dorsalis, and Romberg's test". Emerg Infect Dis. 10 (6): 1160–2. doi:10.3201/eid1006.031117. PMC 3323152. PMID 15224672.
- ↑ Pandey S (2011). "Magnetic resonance imaging of the spinal cord in a man with tabes dorsalis". J Spinal Cord Med. 34 (6): 609–11. doi:10.1179/2045772311Y.0000000041. PMC 3237288. PMID 22330117.
- ↑ Schöfer H (2004). "[Syphilis. Clinical aspects of Treponema pallidum infection]". Hautarzt. 55 (1): 112–9. doi:10.1007/s00105-003-0608-0. PMID 14749871.
- ↑ Kaynak G, Birsel O, Güven MF, Oğüt T (2013). "An overview of the Charcot foot pathophysiology". Diabet Foot Ankle. 4. doi:10.3402/dfa.v4i0.21117. PMC 3733015. PMID 23919113.
- ↑ Tso MK, Koo K, Tso GY (2008). "Neurosyphilis in a non-HIV patient: more than a psychiatric concern". Mcgill J Med. 11 (2): 160–3. PMC 2582679. PMID 19148316.