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'''Double-stranded RNA-binding protein Staufen homolog 1''' is a [[protein]] that in humans is encoded by the ''STAU1'' [[gene]].<ref name="pmid8884277">{{cite journal | vauthors = DesGroseillers L, Lemieux N | title = Localization of a human double-stranded RNA-binding protein gene (STAU) to band 20q13.1 by fluorescence in situ hybridization | journal = Genomics | volume = 36 | issue = 3 | pages = 527–9 |date=Feb 1997 | pmid = 8884277 | pmc = | doi = 10.1006/geno.1996.0499 }}</ref><ref name="pmid15680326">{{cite journal | vauthors = Kim YK, Furic L, Desgroseillers L, Maquat LE | title = Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay | journal = Cell | volume = 120 | issue = 2 | pages = 195–208 |date=Jan 2005 | pmid = 15680326 | pmc =  | doi = 10.1016/j.cell.2004.11.050 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STAU1 staufen, RNA binding protein, homolog 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6780| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Staufen, RNA binding protein, homolog 1 (Drosophila)
| HGNCid = 11370
| Symbol = STAU1
| AltSymbols =; FLJ25010; STAU
| OMIM = 601716
| ECnumber = 
| Homologene = 3384
| MGIid = 1338864
| GeneAtlas_image1 = PBB_GE_STAU1_208948_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_STAU1_207320_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_STAU1_211505_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003725 |text = double-stranded RNA binding}} {{GNF_GO|id=GO:0005478 |text = transporter activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005791 |text = rough endoplasmic reticulum}} {{GNF_GO|id=GO:0005875 |text = microtubule associated complex}} {{GNF_GO|id=GO:0030529 |text = ribonucleoprotein complex}}  
| Process = {{GNF_GO|id=GO:0008298 |text = intracellular mRNA localization}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6780
    | Hs_Ensembl = ENSG00000124214
    | Hs_RefseqProtein = NP_001032405
    | Hs_RefseqmRNA = NM_001037328
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 47163285
    | Hs_GenLoc_end = 47238311
    | Hs_Uniprot = O95793
    | Mm_EntrezGene = 20853
    | Mm_Ensembl = ENSMUSG00000039536
    | Mm_RefseqmRNA = NM_011490
    | Mm_RefseqProtein = NP_035620
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 166639352
    | Mm_GenLoc_end = 166687441
    | Mm_Uniprot = Q3TJ07
  }}
}}
'''Staufen, RNA binding protein, homolog 1 (Drosophila)''', also known as '''STAU1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: STAU1 staufen, RNA binding protein, homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6780| accessdate = }}</ref>


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| section_title =  
| summary_text = Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR.<ref name="entrez">{{cite web | title = Entrez Gene: STAU1 staufen, RNA binding protein, homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6780| accessdate = }}</ref>
| summary_text = Staufen is a member of the family of [[RNA#Double-stranded RNA|double-stranded RNA]] (dsRNA)-binding proteins involved in the transport and/or localization of [[Messenger RNA|mRNAs]] to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule-binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the [[rough endoplasmic reticulum]] (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Kiebler MA, DesGroseillers L |title=Molecular insights into mRNA transport and local translation in the mammalian nervous system. |journal=Neuron |volume=25 |issue= 1 |pages= 19-28 |year= 2000 |pmid= 10707969 |doi=  }}
*{{cite journal  | vauthors=Kiebler MA, DesGroseillers L |title=Molecular insights into mRNA transport and local translation in the mammalian nervous system. |journal=Neuron |volume=25 |issue= 1 |pages= 19–28 |year= 2000 |pmid= 10707969 |doi=10.1016/S0896-6273(00)80868-5 }}
*{{cite journal | author=DesGroseillers L, Lemieux N |title=Localization of a human double-stranded RNA-binding protein gene (STAU) to band 20q13.1 by fluorescence in situ hybridization. |journal=Genomics |volume=36 |issue= 3 |pages= 527-9 |year= 1997 |pmid= 8884277 |doi= 10.1006/geno.1996.0499 }}
*{{cite journal   |vauthors=Marión RM, Fortes P, Beloso A, etal |title=A human sequence homologue of Staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 2212–9 |year= 1999 |pmid= 10022908 |doi= | pmc=84014  }}
*{{cite journal | author=Marión RM, Fortes P, Beloso A, ''et al.'' |title=A human sequence homologue of Staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 2212-9 |year= 1999 |pmid= 10022908 |doi=  }}
*{{cite journal   |vauthors=Wickham L, Duchaîne T, Luo M, etal |title=Mammalian staufen is a double-stranded-RNA- and tubulin-binding protein which localizes to the rough endoplasmic reticulum. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 2220–30 |year= 1999 |pmid= 10022909 |doi= | pmc=84015 }}
*{{cite journal | author=Wickham L, Duchaîne T, Luo M, ''et al.'' |title=Mammalian staufen is a double-stranded-RNA- and tubulin-binding protein which localizes to the rough endoplasmic reticulum. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 2220-30 |year= 1999 |pmid= 10022909 |doi= }}
*{{cite journal   |vauthors=Falcón AM, Fortes P, Marión RM, etal |title=Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro. |journal=Nucleic Acids Res. |volume=27 |issue= 11 |pages= 2241–7 |year= 1999 |pmid= 10325410 |doi=10.1093/nar/27.11.2241  | pmc=148787  }}
*{{cite journal | author=Falcón AM, Fortes P, Marión RM, ''et al.'' |title=Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro. |journal=Nucleic Acids Res. |volume=27 |issue= 11 |pages= 2241-7 |year= 1999 |pmid= 10325410 |doi=  }}
*{{cite journal   |vauthors=Mouland AJ, Mercier J, Luo M, etal |title=The double-stranded RNA-binding protein Staufen is incorporated in human immunodeficiency virus type 1: evidence for a role in genomic RNA encapsidation. |journal=J. Virol. |volume=74 |issue= 12 |pages= 5441–51 |year= 2000 |pmid= 10823848 |doi=10.1128/JVI.74.12.5441-5451.2000  | pmc=112028 }}
*{{cite journal | author=Mouland AJ, Mercier J, Luo M, ''et al.'' |title=The double-stranded RNA-binding protein Staufen is incorporated in human immunodeficiency virus type 1: evidence for a role in genomic RNA encapsidation. |journal=J. Virol. |volume=74 |issue= 12 |pages= 5441-51 |year= 2000 |pmid= 10823848 |doi=  }}
*{{cite journal   |vauthors=Wiemann S, Weil B, Wellenreuther R, etal |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal   |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  | vauthors=Monshausen M, Rehbein M, Richter D, Kindler S |title=The RNA-binding protein Staufen from rat brain interacts with protein phosphatase-1. |journal=J. Neurochem. |volume=81 |issue= 3 |pages= 557–64 |year= 2002 |pmid= 12065664 |doi=10.1046/j.1471-4159.2002.00887.x  }}
*{{cite journal  | author=Monshausen M, Rehbein M, Richter D, Kindler S |title=The RNA-binding protein Staufen from rat brain interacts with protein phosphatase-1. |journal=J. Neurochem. |volume=81 |issue= 3 |pages= 557-64 |year= 2002 |pmid= 12065664 |doi= }}
*{{cite journal  | vauthors=Luo M, Duchaîne TF, DesGroseillers L |title=Molecular mapping of the determinants involved in human Staufen-ribosome association. |journal=Biochem. J. |volume=365 |issue= Pt 3 |pages= 817–24 |year= 2002 |pmid= 12133005 |doi=   10.1042/BJ20020263| pmc=1222739 }}
*{{cite journal | author=Luo M, Duchaîne TF, DesGroseillers L |title=Molecular mapping of the determinants involved in human Staufen-ribosome association. |journal=Biochem. J. |volume=365 |issue= Pt 3 |pages= 817-24 |year= 2002 |pmid= 12133005 |doi= 10.1042/ }}
*{{cite journal   |vauthors=Ohashi S, Koike K, Omori A, etal |title=Identification of mRNA/protein (mRNP) complexes containing Puralpha, mStaufen, fragile X protein, and myosin Va and their association with rough endoplasmic reticulum equipped with a kinesin motor. |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37804–10 |year= 2002 |pmid= 12147688 |doi= 10.1074/jbc.M203608200 }}
*{{cite journal | author=Ohashi S, Koike K, Omori A, ''et al.'' |title=Identification of mRNA/protein (mRNP) complexes containing Puralpha, mStaufen, fragile X protein, and myosin Va and their association with rough endoplasmic reticulum equipped with a kinesin motor. |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37804-10 |year= 2002 |pmid= 12147688 |doi= 10.1074/jbc.M203608200 }}
*{{cite journal   |vauthors=Angenstein F, Evans AM, Settlage RE, etal |title=A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons. |journal=J. Neurosci. |volume=22 |issue= 20 |pages= 8827–37 |year= 2002 |pmid= 12388589 |doi= }}
*{{cite journal | author=Angenstein F, Evans AM, Settlage RE, ''et al.'' |title=A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons. |journal=J. Neurosci. |volume=22 |issue= 20 |pages= 8827-37 |year= 2002 |pmid= 12388589 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Macchi P, Kroening S, Palacios IM, etal |title=Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner. |journal=J. Neurosci. |volume=23 |issue= 13 |pages= 5778–88 |year= 2003 |pmid= 12843282 |doi= }}
*{{cite journal | author=Macchi P, Kroening S, Palacios IM, ''et al.'' |title=Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner. |journal=J. Neurosci. |volume=23 |issue= 13 |pages= 5778-88 |year= 2003 |pmid= 12843282 |doi= }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Chatel-Chaix L, Clément JF, Martel C, etal |title=Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles. |journal=Mol. Cell. Biol. |volume=24 |issue= 7 |pages= 2637–48 |year= 2004 |pmid= 15024055 |doi=10.1128/MCB.24.7.2637-2648.2004  | pmc=371130  }}
*{{cite journal  | author=Chatel-Chaix L, Clément JF, Martel C, ''et al.'' |title=Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles. |journal=Mol. Cell. Biol. |volume=24 |issue= 7 |pages= 2637-48 |year= 2004 |pmid= 15024055 |doi=  }}
*{{cite journal  | vauthors=Villacé P, Marión RM, Ortín J |title=The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs. |journal=Nucleic Acids Res. |volume=32 |issue= 8 |pages= 2411–20 |year= 2004 |pmid= 15121898 |doi= 10.1093/nar/gkh552 | pmc=419443 }}
*{{cite journal | author=Villacé P, Marión RM, Ortín J |title=The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs. |journal=Nucleic Acids Res. |volume=32 |issue= 8 |pages= 2411-20 |year= 2004 |pmid= 15121898 |doi= 10.1093/nar/gkh552 }}
*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104  | pmc=442148 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal   |vauthors=Brendel C, Rehbein M, Kreienkamp HJ, etal |title=Characterization of Staufen 1 ribonucleoprotein complexes. |journal=Biochem. J. |volume=384 |issue= Pt 2 |pages= 239–46 |year= 2005 |pmid= 15303970 |doi= 10.1042/BJ20040812 | pmc=1134106 }}
*{{cite journal | author=Brendel C, Rehbein M, Kreienkamp HJ, ''et al.'' |title=Characterization of Staufen 1 ribonucleoprotein complexes. |journal=Biochem. J. |volume=384 |issue= Pt 2 |pages= 239-46 |year= 2005 |pmid= 15303970 |doi= 10.1042/BJ20040812 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 07:10, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Double-stranded RNA-binding protein Staufen homolog 1 is a protein that in humans is encoded by the STAU1 gene.[1][2][3]

Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule-binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR.[3]

References

  1. ↑ DesGroseillers L, Lemieux N (Feb 1997). "Localization of a human double-stranded RNA-binding protein gene (STAU) to band 20q13.1 by fluorescence in situ hybridization". Genomics. 36 (3): 527–9. doi:10.1006/geno.1996.0499. PMID 8884277.
  2. ↑ Kim YK, Furic L, Desgroseillers L, Maquat LE (Jan 2005). "Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay". Cell. 120 (2): 195–208. doi:10.1016/j.cell.2004.11.050. PMID 15680326.
  3. ↑ 3.0 3.1 "Entrez Gene: STAU1 staufen, RNA binding protein, homolog 1 (Drosophila)".

Further reading



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