CPSF3: Difference between revisions

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{{Infobox_gene}}
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'''Cleavage and polyadenylation specificity factor subunit 3''' is a [[protein]] that in humans is encoded by the ''CPSF3'' [[gene]].<ref name="pmid8929409">{{cite journal | vauthors = Jenny A, Minvielle-Sebastia L, Preker PJ, Keller W | title = Sequence similarity between the 73-kilodalton protein of mammalian CPSF and a subunit of yeast polyadenylation factor I | journal = Science | volume = 274 | issue = 5292 | pages = 1514–7 |date=Dec 1996 | pmid = 8929409 | pmc =  | doi =10.1126/science.274.5292.1514 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CPSF3 cleavage and polyadenylation specific factor 3, 73kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51692| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_CPSF3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2i7t.
| PDB = {{PDB2|2i7t}}, {{PDB2|2i7v}}
| Name = Cleavage and polyadenylation specific factor 3, 73kDa
| HGNCid = 2326
| Symbol = CPSF3
| AltSymbols =; CPSF; CPSF-73; CPSF73
| OMIM = 606029
| ECnumber =
| Homologene = 6499
| MGIid = 1859328
  | Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}}
| Process = {{GNF_GO|id=GO:0006378 |text = mRNA polyadenylation}} {{GNF_GO|id=GO:0006379 |text = mRNA cleavage}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51692
    | Hs_Ensembl = ENSG00000119203
    | Hs_RefseqProtein = NP_057291
    | Hs_RefseqmRNA = NM_016207
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 9481148
    | Hs_GenLoc_end = 9530681
    | Hs_Uniprot = Q9UKF6
    | Mm_EntrezGene = 54451
    | Mm_Ensembl = ENSMUSG00000054309
    | Mm_RefseqmRNA = NM_018813
    | Mm_RefseqProtein = NP_061283
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 21532908
    | Mm_GenLoc_end = 21561324
    | Mm_Uniprot = Q3TC91
  }}
}}
'''Cleavage and polyadenylation specific factor 3, 73kDa''', also known as '''CPSF3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CPSF3 cleavage and polyadenylation specific factor 3, 73kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51692| accessdate = }}</ref>


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==Model organisms==
[[Model organism]]s have been used in the study of CPSF3 function. A conditional [[knockout mouse]] line called ''Cpsf3<sup>tm1b(EUCOMM)Wtsi</sup>'' was generated at the [[Wellcome Trust Sanger Institute]].<ref name="mgp_reference">{{cite journal |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |journal=Acta Ophthalmologica|volume=88 |pages=925–7|doi=10.1111/j.1755-3768.2010.4142.x }}</ref> Male and female animals underwent a standardized [[phenotypic screen]]<ref name="IMPCsearch_ref">{{cite web |url=http://www.mousephenotype.org/data/search?q=Cpsf3#fq=*:*&facet=gene |title=International Mouse Phenotyping Consortium}}</ref> to determine the effects of deletion.<ref name="pmid21677750">{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}</ref><ref name="mouse_library">{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}</ref><ref name="mouse_for_all_reasons">{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}</ref><ref name="pmid23870131">{{cite journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, ((Sanger Institute Mouse Genetics Project)), Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | year = 2013 | pmid = 23870131 | doi = 10.1016/j.cell.2013.06.022 | pmc=3717207}}</ref> Additional screens performed:  - In-depth immunological phenotyping<ref name="iii_ref">{{cite web |url= http://www.immunophenotyping.org/data/search?keys=Cpsf3&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}</ref>
{| class="wikitable sortable collapsible collapsed" border="1" cellpadding="2" style="float: left;" |
|+ ''Cpsf3'' knockout mouse phenotype
|-
! Characteristic!! Phenotype
|-
| colspan=2; style="text-align: center;" | All data available at.<ref name="IMPCsearch_ref"/><ref name="iii_ref" />
|-
| Insulin || bgcolor="#488ED3"|Normal
|-
| Homozygous viability at P14 || bgcolor="#C40000"|Abnormal
|-
| [[Recessive]] lethal study || bgcolor="#C40000"|Abnormal
|-
| Body weight || bgcolor="#488ED3"|Normal
|-
| Neurological assessment || bgcolor="#488ED3"|Normal
|-
| Grip strength || bgcolor="#488ED3"|Normal
|-
| [[Dysmorphology]] || bgcolor="#488ED3"|Normal
|-
| [[Indirect calorimetry]] || bgcolor="#488ED3"|Normal
|-
| [[Glucose tolerance test]] || bgcolor="#488ED3"|Normal
|-
| [[Auditory brainstem response]] || bgcolor="#488ED3"|Normal
|-
| [[Dual-energy X-ray absorptiometry|DEXA]] || bgcolor="#488ED3"|Normal
|-
| [[Radiography]] || bgcolor="#488ED3"|Normal
|-
| Eye morphology || bgcolor="#488ED3"|Normal
|-
| [[Clinical chemistry]] || bgcolor="#488ED3"|Normal
|-
| ''[[Haematology]]'' 16 Weeks || bgcolor="#488ED3"|Normal
|-
| Peripheral blood leukocytes 16 Weeks || bgcolor="#488ED3"|Normal
|-
| ''[[Salmonella]]'' infection || bgcolor="#488ED3"|Normal
|-
| Epidermal Immune Composition || bgcolor="#488ED3"|Normal
|-
| Influenza Challenge || bgcolor="#488ED3"|Normal
|}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CPSF3}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Murthy KG, Manley JL |title=The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. |journal=Genes Dev. |volume=9 |issue= 21 |pages= 2672-83 |year= 1995 |pmid= 7590244 |doi=  }}
*{{cite journal  | vauthors=Murthy KG, Manley JL |title=The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation. |journal=Genes Dev. |volume=9 |issue= 21 |pages= 2672–83 |year= 1995 |pmid= 7590244 |doi=10.1101/gad.9.21.2672 }}
*{{cite journal  | author=Jenny A, Hauri HP, Keller W |title=Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit. |journal=Mol. Cell. Biol. |volume=14 |issue= 12 |pages= 8183-90 |year= 1994 |pmid= 7969155 |doi=  }}
*{{cite journal  | vauthors=Jenny A, Hauri HP, Keller W |title=Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit. |journal=Mol. Cell. Biol. |volume=14 |issue= 12 |pages= 8183–90 |year= 1994 |pmid= 7969155 |doi= | pmc=359357 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Thuresson AC, Aström J, Aström A, ''et al.'' |title=Multiple forms of poly(A) polymerases in human cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 3 |pages= 979-83 |year= 1994 |pmid= 8302877 |doi= }}
*{{cite journal  | vauthors=Thuresson AC, Aström J, Aström A |title=Multiple forms of poly(A) polymerases in human cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 3 |pages= 979–83 |year= 1994 |pmid= 8302877 |doi=10.1073/pnas.91.3.979 | pmc=521437  |display-authors=etal}}
*{{cite journal | author=Jenny A, Minvielle-Sebastia L, Preker PJ, Keller W |title=Sequence similarity between the 73-kilodalton protein of mammalian CPSF and a subunit of yeast polyadenylation factor I. |journal=Science |volume=274 |issue= 5292 |pages= 1514-7 |year= 1996 |pmid= 8929409 |doi=  }}
*{{cite journal  | vauthors=McCracken S, Fong N, Yankulov K |title=The C-terminal domain of RNA polymerase II couples mRNA processing to transcription. |journal=Nature |volume=385 |issue= 6614 |pages= 357–61 |year= 1997 |pmid= 9002523 |doi= 10.1038/385357a0 |display-authors=etal}}
*{{cite journal  | author=McCracken S, Fong N, Yankulov K, ''et al.'' |title=The C-terminal domain of RNA polymerase II couples mRNA processing to transcription. |journal=Nature |volume=385 |issue= 6614 |pages= 357-61 |year= 1997 |pmid= 9002523 |doi= 10.1038/385357a0 }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | vauthors=Takagaki Y, Manley JL |title=Complex protein interactions within the human polyadenylation machinery identify a novel component. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1515–25 |year= 2000 |pmid= 10669729 |doi=10.1128/MCB.20.5.1515-1525.2000  | pmc=85326 }}
*{{cite journal  | author=Takagaki Y, Manley JL |title=Complex protein interactions within the human polyadenylation machinery identify a novel component. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1515-25 |year= 2000 |pmid= 10669729 |doi=  }}
*{{cite journal  | vauthors=de Vries H, Rüegsegger U, Hübner W |title=Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors. |journal=EMBO J. |volume=19 |issue= 21 |pages= 5895–904 |year= 2000 |pmid= 11060040 |doi= 10.1093/emboj/19.21.5895 | pmc=305781 |display-authors=etal}}
*{{cite journal  | author=de Vries H, Rüegsegger U, Hübner W, ''et al.'' |title=Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors. |journal=EMBO J. |volume=19 |issue= 21 |pages= 5895-904 |year= 2000 |pmid= 11060040 |doi= 10.1093/emboj/19.21.5895 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Kaufmann I, Martin G, Friedlein A |title=Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. |journal=EMBO J. |volume=23 |issue= 3 |pages= 616–26 |year= 2005 |pmid= 14749727 |doi= 10.1038/sj.emboj.7600070 | pmc=1271804 |display-authors=etal}}
*{{cite journal  | author=Kaufmann I, Martin G, Friedlein A, ''et al.'' |title=Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. |journal=EMBO J. |volume=23 |issue= 3 |pages= 616-26 |year= 2005 |pmid= 14749727 |doi= 10.1038/sj.emboj.7600070 }}
*{{cite journal  | vauthors=Calzado MA, Sancho R, Muñoz E |title=Human immunodeficiency virus type 1 Tat increases the expression of cleavage and polyadenylation specificity factor 73-kilodalton subunit modulating cellular and viral expression. |journal=J. Virol. |volume=78 |issue= 13 |pages= 6846–54 |year= 2004 |pmid= 15194760 |doi= 10.1128/JVI.78.13.6846-6854.2004 | pmc=421638 }}
*{{cite journal  | author=Calzado MA, Sancho R, Muñoz E |title=Human immunodeficiency virus type 1 Tat increases the expression of cleavage and polyadenylation specificity factor 73-kilodalton subunit modulating cellular and viral expression. |journal=J. Virol. |volume=78 |issue= 13 |pages= 6846-54 |year= 2004 |pmid= 15194760 |doi= 10.1128/JVI.78.13.6846-6854.2004 }}
*{{cite journal  | vauthors=Jin J, Smith FD, Stark C |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |display-authors=etal}}
*{{cite journal  | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Mandel CR, Kaneko S, Zhang H |title=Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease. |journal=Nature |volume=444 |issue= 7121 |pages= 953–6 |year= 2007 |pmid= 17128255 |doi= 10.1038/nature05363 |display-authors=etal}}
*{{cite journal  | author=Mandel CR, Kaneko S, Zhang H, ''et al.'' |title=Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease. |journal=Nature |volume=444 |issue= 7121 |pages= 953-6 |year= 2007 |pmid= 17128255 |doi= 10.1038/nature05363 }}
*{{cite journal  | vauthors=de la Vega L, Sánchez-Duffhues G, Fresno M |title=The 73 kDa subunit of the CPSF complex binds to the HIV-1 LTR promoter and functions as a negative regulatory factor that is inhibited by the HIV-1 Tat protein. |journal=J. Mol. Biol. |volume=372 |issue= 2 |pages= 317–30 |year= 2007 |pmid= 17669424 |doi= 10.1016/j.jmb.2007.06.075 |display-authors=etal}}
*{{cite journal  | author=de la Vega L, Sánchez-Duffhues G, Fresno M, ''et al.'' |title=The 73 kDa subunit of the CPSF complex binds to the HIV-1 LTR promoter and functions as a negative regulatory factor that is inhibited by the HIV-1 Tat protein. |journal=J. Mol. Biol. |volume=372 |issue= 2 |pages= 317-30 |year= 2007 |pmid= 17669424 |doi= 10.1016/j.jmb.2007.06.075 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=51692}}
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Revision as of 10:00, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cleavage and polyadenylation specificity factor subunit 3 is a protein that in humans is encoded by the CPSF3 gene.[1][2]


Model organisms

Model organisms have been used in the study of CPSF3 function. A conditional knockout mouse line called Cpsf3tm1b(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[3] Male and female animals underwent a standardized phenotypic screen[4] to determine the effects of deletion.[5][6][7][8] Additional screens performed: - In-depth immunological phenotyping[9]

References

  1. ↑ Jenny A, Minvielle-Sebastia L, Preker PJ, Keller W (Dec 1996). "Sequence similarity between the 73-kilodalton protein of mammalian CPSF and a subunit of yeast polyadenylation factor I". Science. 274 (5292): 1514–7. doi:10.1126/science.274.5292.1514. PMID 8929409.
  2. ↑ "Entrez Gene: CPSF3 cleavage and polyadenylation specific factor 3, 73kDa".
  3. ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  4. ↑ 4.0 4.1 "International Mouse Phenotyping Consortium".
  5. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  6. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  7. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  8. ↑ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  9. ↑ 9.0 9.1 "Infection and Immunity Immunophenotyping (3i) Consortium".

External links

Further reading



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