Clinical chemistry
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Clinical chemistry (also known as clinical biochemistry, chemical pathology or pure blood chemistry) is the area of pathology that is generally concerned with analysis of bodily fluids.
The discipline originated in the late 19th century with the use of simple chemical tests for various components of blood and urine. Subsequently other techniques were applied including the use and measurement of enzyme activities, spectrophotometry, electrophoresis and immunoassay.
Most current laboratories are now highly automated and use assays that are closely monitored and quality controlled.
Tests that require examination and measurement of the cells of blood, as well as blood clotting studies, are not included as in the UK these are usually grouped under hematology, but in many countries these specialties along with immunology and microbiology are grouped under laboratory medicine.
All biochemical tests come under chemical pathology. These are performed on any kind of body fluid, but mostly on serum or plasma. Serum is the yellow watery part of blood that is left after blood has been allowed to clot and all blood cells have been removed. This is most easily done by centrifugation which packs the more dense blood cells and platelets to the bottom of the centrifuge tube, leaving the liquid serum fraction resting above the packed cells. Plasma is essentially the same as serum, but is obtained by centrifuging the blood without clotting. Plasma therefore contains all of the clotting factors, including fibrinogen.
A large laboratory will accept samples for up to about 700 different kinds of tests. Even the largest of laboratories rarely does all these tests themselves and some need to be referred to other labs.
This large array of tests can be further sub-categorised into sub-specialities of:
- General or routine chemistry
- Endocrinology - the study of hormones
- Immunology - the study of the immune system and antibodies
- Pharmacology or Toxicology - the study of drugs
Chemical pathology tests
Common chemical pathology tests include:
- Sodium;
- Potassium;
- Chloride;
- Bicarbonate;
- Urea;
- Creatinine;
- Calcium;
- Phosphate;
- Albumin;
- Bilirubin;
- AST;
- ALT;
- GGT;
- Alkaline phosphatase;
- Magnesium;
- Osmolality;
- Urate;
- Iron;
- Transferrin;
- Total protein;
- Globulins;
- Glucose;
- C-reactive protein;
- HbA1c.
- Blood gases (
![[H^+], P_{{\mathrm{CO}}_2} , P_{{\mathrm{O}}_2}](/images/math/4/8/f/48f972c201db0b62b3ca5cc69a42dc27.png)
)
See also
de:Klinische Chemiefr:Biochimie clinique it:Chimica clinica nl:Klinische chemie no:Klinisk kjemi fi:Kliininen kemia
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
