Non-alcoholic fatty liver disease natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
[[NASH]] may progress to [[fibrosis]] and, later, [[cirrhosis]]. Studies of serial [[liver biopsies]] estimate a 26-37% rate of [[hepatic]] [[fibrosis]] and 2-15% rate of [[cirrhosis]] in less than 6 years.The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies.The natural history of nonalcoholic fatty liver disease:a clinical histopathological study.Long-term follow-up of patients with NAFLD and elevated liver enzymes. In 2001, [[NASH]] represented 2.9% of the indications of [[liver transplantation]].The frequency of Nonalcoholic Steatohepatitis as a Cause of Advanced Liver Disease. The impact of [[NAFLD]] is manifest at each step along the spectrum of the disease. Studies in the United States and Sweden have revealed that both simple [[steatosis]] as well as [[steatohepatitis]] significantly reduce life expectancy, even when the diagnosis is made in children | [[NASH]] may progress to [[fibrosis]] and, later, [[cirrhosis]]. Studies of serial [[liver biopsies]] estimate a 26-37% rate of [[hepatic]] [[fibrosis]] and 2-15% rate of [[cirrhosis]] in less than 6 years.The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies.The natural history of nonalcoholic fatty liver disease:a clinical histopathological study.Long-term follow-up of patients with NAFLD and elevated liver enzymes. In 2001, [[NASH]] represented 2.9% of the indications of [[liver transplantation]].The frequency of Nonalcoholic Steatohepatitis as a Cause of Advanced Liver Disease. The impact of [[NAFLD]] is manifest at each step along the spectrum of the disease. Studies in the United States and Sweden have revealed that both simple [[steatosis]] as well as [[steatohepatitis]] significantly reduce life expectancy, even when the diagnosis is made in children.The natural history of the non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years. | ||
==Natural History, Complications and Prognosis== | |||
===Natural History=== | ===Natural History=== | ||
*The symptoms of NAFDL usually develop in the | *The symptoms of NAFDL usually develop in the 40th decade of life, And usally aymptomatic at first. | ||
*The symptoms of (disease name) typically develop ___ years after exposure to ___. | *The symptoms of (disease name) typically develop ___ years after exposure to ___. | ||
*If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3]. | *If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3]. | ||
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*The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy]. | *The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy]. | ||
*[Subtype of disease/malignancy] is associated with the most favorable prognosis. | *[Subtype of disease/malignancy] is associated with the most favorable prognosis. | ||
*The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis | *The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis | ||
==References== | ==References== | ||
Revision as of 20:36, 1 December 2017
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Non-Alcoholic Fatty Liver Disease Microchapters |
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Differentiating Non-Alcoholic Fatty Liver Disease from other Diseases |
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Editor in Chief: Elliot Tapper, M.D., Beth Israel Deaconess Medical Center, C. Michael Gibson, M.S., M.D. [1]
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Overview
NASH may progress to fibrosis and, later, cirrhosis. Studies of serial liver biopsies estimate a 26-37% rate of hepatic fibrosis and 2-15% rate of cirrhosis in less than 6 years.The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies.The natural history of nonalcoholic fatty liver disease:a clinical histopathological study.Long-term follow-up of patients with NAFLD and elevated liver enzymes. In 2001, NASH represented 2.9% of the indications of liver transplantation.The frequency of Nonalcoholic Steatohepatitis as a Cause of Advanced Liver Disease. The impact of NAFLD is manifest at each step along the spectrum of the disease. Studies in the United States and Sweden have revealed that both simple steatosis as well as steatohepatitis significantly reduce life expectancy, even when the diagnosis is made in children.The natural history of the non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years.
Natural History, Complications and Prognosis
Natural History
- The symptoms of NAFDL usually develop in the 40th decade of life, And usally aymptomatic at first.
- The symptoms of (disease name) typically develop ___ years after exposure to ___.
- If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
Complications
- Common complications of [disease name] include:
- [Complication 1]
- [Complication 2]
- [Complication 3]
Prognosis
- Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
- Depending on the extent of the [tumor/disease progression/etc.] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
- The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
- [Subtype of disease/malignancy] is associated with the most favorable prognosis.
- The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis