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|-style="background: #4479BA; color: #FFFFFF; text-align: center;" | |-style="background: #4479BA; color: #FFFFFF; text-align: center;" | ||
|- | |- | ||
|style="background: #DCDCDC; padding: 5px; text-align: center;" | Congenital Syphilis | |style="background: #DCDCDC; padding: 5px; text-align: center;" | [[Congenital Syphilis]] | ||
|style="background: #F5F5F5; padding: 5px;" |Treponema Pallidum | |style="background: #F5F5F5; padding: 5px;" |[[Treponema Pallidum]] | ||
|style="background: #F5F5F5; padding: 5px;" |Vertical | |style="background: #F5F5F5; padding: 5px;" |Vertical | ||
|style="background: #F5F5F5; padding: 5px;" |16th to 28th week | |style="background: #F5F5F5; padding: 5px;" |16th to 28th week | ||
|style="background: #F5F5F5; padding: 5px;" |Based on the stage of Syphilis infection | |style="background: #F5F5F5; padding: 5px;" |Based on the stage of [[Syphilis]] infection | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Low birth weight | *[[Low birth weight]] | ||
*Non-immune Hydrops | *Non-immune [[Hydrops]] | ||
*Maculopapular or Vesicobullous rash on the palms and soles | *[[Maculopapular]] or [[Vesicobullous]] [[rash]] on the palms and soles | ||
*Interstitial Keratitis | *Interstitial [[Keratitis]] | ||
*Rhinitis | *[[Rhinitis]] | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Early congenital syphilis | *Early congenital syphilis | ||
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*Stigmata | *Stigmata | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Detection of IgM aganist T.pallidum in blood collected in chordocentesis | *Detection of [[IgM]] aganist [[T.pallidum]] in [[blood]] collected in [[chordocentesis]] | ||
*Amniotic fluid PCR for T. pallidum DNA | *[[Amniotic fluid]] [[PCR]] for [[T. pallidum]] [[DNA]] | ||
*Antenatal Ultrasound | *Antenatal [[Ultrasound]] | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Aqueous crystalline penicillin G | *Aqueous crystalline [[penicillin G]] | ||
|- | |- | ||
|style="background: #DCDCDC; padding: 5px; text-align: center;" |Congenital Toxoplasmosis | |style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Congenital Toxoplasmosis]] | ||
|style="background: #F5F5F5; padding: 5px;" |Toxoplama gondii | |style="background: #F5F5F5; padding: 5px;" |[[Toxoplama gondii]] | ||
|style="background: #F5F5F5; padding: 5px;" |Vertical | |style="background: #F5F5F5; padding: 5px;" |Vertical | ||
|style="background: #F5F5F5; padding: 5px;" |Third Trimester | |style="background: #F5F5F5; padding: 5px;" |[[Third Trimester]] | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Majority : Asymptomatic | *Majority : Asymptomatic | ||
*Few patients can have flu like symptoms | *Few patients can have [[flu]] like symptoms | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Low birth weight | *[[Low birth weight]] | ||
*Chorioretinitis | *[[Chorioretinitis]] | ||
*Microcephaly | *[[Microcephaly]] | ||
*Intracranial calcification | *[[Intracranial calcification]] | ||
*Spasticities and Paresis | *Spasticities and Paresis | ||
*Sensorineural | *[[Sensorineural hearing loss]] | ||
|style="background: #F5F5F5; padding: 5px;" | None | |style="background: #F5F5F5; padding: 5px;" | None | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Amniotic fluid PCR for T.gondii DNA | *[[Amniotic fluid]] [[PCR]] for [[T.gondii]] [[DNA]] | ||
*Detection of parasite in | *Detection of [[parasite]] in [[amniotic fluid]] | ||
*Serology | *[[Serology]] | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Infected mothers without fetal infection : Spiramycin | *Infected mothers without [[fetal]] infection : [[Spiramycin]] | ||
*Infected mothers with established fetal infection : Pyrimethamine, sulfadiazine, and folinic acid | *Infected mothers with established [[fetal]] infection : [[Pyrimethamine]], [[sulfadiazine]], and [[folinic acid]] | ||
|- | |- | ||
|style="background: #DCDCDC; padding: 5px; text-align: center;" |Congenital Varicella Syndrome | |style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Congenital Varicella Syndrome]] | ||
|style="background: #F5F5F5; padding: 5px;" |Varicella Zoster virus | |style="background: #F5F5F5; padding: 5px;" |[[Varicella Zoster virus]] | ||
|style="background: #F5F5F5; padding: 5px;" |Vertical | |style="background: #F5F5F5; padding: 5px;" |Vertical | ||
|style="background: #F5F5F5; padding: 5px;" |13 to 20th week | |style="background: #F5F5F5; padding: 5px;" |13 to 20th week | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Vesicular skin rash | *Vesicular skin rash | ||
*Fever | *[[Fever]] | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Cicatrical skin lesions | *Cicatrical skin lesions | ||
*Limb hypoplasia | *Limb hypoplasia | ||
*Microcephaly | *[[Microcephaly]] | ||
*Autonomic instability | *[[Autonomic instability]] | ||
*Chorioretinitis | *[[Chorioretinitis]] | ||
*Microphalmia and anisocoria | *[[Microphalmia]] and [[anisocoria]] | ||
|style="background: #F5F5F5; padding: 5px;" |None | |style="background: #F5F5F5; padding: 5px;" |None | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Antenatal Ultrasound | *[[Antenatal Ultrasound]] | ||
*Fetal MRI | *Fetal [[MRI]] | ||
*Amniotic fluid PCR for VZV DNA | *[[Amniotic fluid]] [[PCR]] for [[VZV]] [[DNA]] | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Termination of pregnancy with severe defects | *Termination of [[pregnancy]] with severe defects | ||
*No definitive treatment | *No definitive treatment | ||
*Preconceptional vaccination | *Preconceptional [[vaccination]] | ||
|- | |- | ||
|style="background: #DCDCDC; padding: 5px; text-align: center;" |Congenital CMV | |style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Congenital CMV]] | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" |[[Cytomegalo Virus]] | ||
|style="background: #F5F5F5; padding: 5px;" |Vertical | |style="background: #F5F5F5; padding: 5px;" |Vertical | ||
|style="background: #F5F5F5; padding: 5px;" |First trimester | |style="background: #F5F5F5; padding: 5px;" |[[First trimester]] | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Fever | *[[Fever]] | ||
*Cervical lymphadenopathy | *[[Cervical lymphadenopathy]] | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*[[Small for gestational age|SGA]] | *[[Small for gestational age|SGA]] | ||
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*Asymptomatic | *Asymptomatic | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Antenatal Ultrasound | *[[Antenatal Ultrasound]] | ||
*Amniotic Fluid PCR for CMV DNA | *[[Amniotic Fluid]] [[PCR]] for [[CMV]] [[DNA]] | ||
*CT brain | *[[CT]] [[brain]] | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*IV Ganciclovir | *IV [[Ganciclovir]] | ||
*Oral Valganciclovir | *Oral [[Valganciclovir]] | ||
|- | |- | ||
|style="background: #DCDCDC; padding: 5px; text-align: center;" |Congenital Rubella Syndrome | |style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Congenital Rubella Syndrome]] | ||
|style="background: #F5F5F5; padding: 5px;" |Rubella | |style="background: #F5F5F5; padding: 5px;" |[[Rubella]] Virus | ||
|style="background: #F5F5F5; padding: 5px;" |Vertical | |style="background: #F5F5F5; padding: 5px;" |Vertical | ||
|style="background: #F5F5F5; padding: 5px;" |8 to 10th week | |style="background: #F5F5F5; padding: 5px;" |8 to 10th week | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Asymptomatic | *Asymptomatic | ||
*Maculopapular rash starting on the face and spreads caudally | *[[Maculopapular rash]] starting on the [[face]] and spreads caudally | ||
*Polyarthalgia | *[[Polyarthalgia]] | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Low birth weight | *[[Low birth weight]] | ||
*VSD and PDA | *[[VSD]] and [[PDA]] | ||
*Cataracts, glacoma, retinopathy | *[[Cataracts]], [[glacoma]], [[retinopathy]] | ||
*Sensorineural hearing loss | *[[Sensorineural hearing loss]] | ||
*Microcephaly | *[[Microcephaly]] | ||
*Encephalitis | *[[Encephalitis]] | ||
|style="background: #F5F5F5; padding: 5px;" |None | |style="background: #F5F5F5; padding: 5px;" |None | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
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* [[Viral]] [[nucleic acid]] quantification | * [[Viral]] [[nucleic acid]] quantification | ||
* Detection of [[IgM]]/ [[IgA]] [[antibodies]] in [[fetal]] [[blood]] | * Detection of [[IgM]]/ [[IgA]] [[antibodies]] in [[fetal]] [[blood]] | ||
*Serological Testing | *[[Serological Testing]] | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Termination of pregnancy: If infection diagnosed before | *Termination of pregnancy: If infection diagnosed before 18 weeks of [[pregnancy]] | ||
*No definitive Treatment | *No definitive Treatment | ||
|- | |- | ||
|style="background: #DCDCDC; padding: 5px; text-align: center;" |Neonatal Herpes Simplex | |style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Neonatal Herpes Simplex]] | ||
|style="background: #F5F5F5; padding: 5px;" |HSV-1 and HSV-2 | |style="background: #F5F5F5; padding: 5px;" |[[HSV-1]] and [[HSV-2]] | ||
|style="background: #F5F5F5; padding: 5px;" |Direct Contact | |style="background: #F5F5F5; padding: 5px;" | | ||
|style="background: #F5F5F5; padding: 5px;" |At term | *Direct Contact / Ascending infection from genital lesions | ||
*Contact with infected people | |||
*Vertical | |||
|style="background: #F5F5F5; padding: 5px;" |At [[term]] | |||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Genital or Orolabial herpes | *[[Genital herpes]] or [[Orolabial herpes]] | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Vesicular skin lesions | *Vesicular skin lesions | ||
*Oral | *[[Oral ulcers]] | ||
*Chorioretinitis and conjunctival erythema | *[[Chorioretinitis]] and [[conjunctival erythema]] | ||
*Encephalitis | *[[Encephalitis]] | ||
*DIC | *[[DIC]] | ||
*Pneumonitis | *[[Pneumonitis]] | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Skin, eye, mouth disease (SEM) | *Skin, eye, mouth disease (SEM) | ||
*CNS Disease | *[[CNS]] Disease | ||
*Disseminated Disease | *Disseminated Disease | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*Surface Cultures | *Surface Cultures | ||
* | *[[CSF]] analysis | ||
*Elevated Alanine Transaminase | *Elevated [[Alanine Transaminase]] | ||
|style="background: #F5F5F5; padding: 5px;" | | |style="background: #F5F5F5; padding: 5px;" | | ||
*SEM : IV Acyclovir for 10 days | *SEM : IV [[Acyclovir]] for 10 days | ||
*Disseminated and CNS disease: IV Acyclovir for 14 to 21 days | *Disseminated and [[CNS]] disease: IV [[Acyclovir]] for 14 to 21 days | ||
|} | |} |
Revision as of 14:21, 6 March 2017
Diseases | Causative Organism | Transmission | Timing of Infection | Clinical Symptoms in the Mother | Clinical Manifestations in the newborn | Classification | Diagnosis | Treatment |
---|---|---|---|---|---|---|---|---|
Congenital Syphilis | Treponema Pallidum | Vertical | 16th to 28th week | Based on the stage of Syphilis infection |
|
|
|
|
Congenital Toxoplasmosis | Toxoplama gondii | Vertical | Third Trimester |
|
|
None |
|
|
Congenital Varicella Syndrome | Varicella Zoster virus | Vertical | 13 to 20th week |
|
|
None |
|
|
Congenital CMV | Cytomegalo Virus | Vertical | First trimester |
|
|
| ||
Congenital Rubella Syndrome | Rubella Virus | Vertical | 8 to 10th week |
|
None |
|
| |
Neonatal Herpes Simplex | HSV-1 and HSV-2 |
|
At term |
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|
|