Retinoblastoma risk factors: Difference between revisions
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===Viral exposure=== | ===Viral exposure=== | ||
The presence of HPV sequences in retinoblastoma tumor tissue may play a role in the development of sporadic retinoblastoma. | The presence of HPV sequences in retinoblastoma tumor tissue may play a role in the development of sporadic retinoblastoma.<ref name="pmid11051250">{{cite journal| author=Orjuela M, Castaneda VP, Ridaura C, Lecona E, Leal C, Abramson DH et al.| title=Presence of human papilloma virus in tumor tissue from children with retinoblastoma: an alternative mechanism for tumor development. | journal=Clin Cancer Res | year= 2000 | volume= 6 | issue= 10 | pages= 4010-6 | pmid=11051250 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11051250 }} </ref> | ||
===Advanced paternal age=== | ===Advanced paternal age=== | ||
There is evidence suggesting that the mutations of RB1 are more common during spermatogenesis than oogenesis.<ref name="DryjaMukai1989">{{cite journal|last1=Dryja|first1=Thaddeus P.|last2=Mukai|first2=Shizuo|last3=Petersen|first3=Robert|last4=Rapaport|first4=Joyce M.|last5=Walton|first5=David|last6=Yandell|first6=David W.|title=Parental origin of mutations of the retinoblastoma gene|journal=Nature|volume=339|issue=6225|year=1989|pages=556–558|issn=0028-0836|doi=10.1038/339556a0}}</ref> | There is evidence suggesting that the mutations of RB1 are more common during spermatogenesis than oogenesis.<ref name="DryjaMukai1989">{{cite journal|last1=Dryja|first1=Thaddeus P.|last2=Mukai|first2=Shizuo|last3=Petersen|first3=Robert|last4=Rapaport|first4=Joyce M.|last5=Walton|first5=David|last6=Yandell|first6=David W.|title=Parental origin of mutations of the retinoblastoma gene|journal=Nature|volume=339|issue=6225|year=1989|pages=556–558|issn=0028-0836|doi=10.1038/339556a0}}</ref> | ||
==See also== | ==See also== |
Revision as of 19:14, 11 October 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
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Overview
Common risk factors in the development of retinoblastoma are, advanced paternal age, positive family history, and viral exposure.
Common Risk Factors
Family History
Approximately 10% of patients with retinoblastoma have a previously established family history of the disease.
Viral exposure
The presence of HPV sequences in retinoblastoma tumor tissue may play a role in the development of sporadic retinoblastoma.[1]
Advanced paternal age
There is evidence suggesting that the mutations of RB1 are more common during spermatogenesis than oogenesis.[2]
See also
References
- ↑ Orjuela M, Castaneda VP, Ridaura C, Lecona E, Leal C, Abramson DH; et al. (2000). "Presence of human papilloma virus in tumor tissue from children with retinoblastoma: an alternative mechanism for tumor development". Clin Cancer Res. 6 (10): 4010–6. PMID 11051250.
- ↑ Dryja, Thaddeus P.; Mukai, Shizuo; Petersen, Robert; Rapaport, Joyce M.; Walton, David; Yandell, David W. (1989). "Parental origin of mutations of the retinoblastoma gene". Nature. 339 (6225): 556–558. doi:10.1038/339556a0. ISSN 0028-0836.